Inhibitory Effects of Different Selenium Sources on Porcine Parvovirus Infection in vitro

WEI Zhan-yong; CUI Bao-an; HUANG Ke-he; WANG Xue-bin; PAN Cui-ling; GUO Xiao-quan

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December 2005

WEI Zhan-yong, CUI Bao-an, HUANG Ke-he, WANG Xue-bin, PAN Cui-ling and GUO Xiao-quan. Inhibitory Effects of Different Selenium Sources on Porcine Parvovirus Infection in vitro[J]. Virologica Sinica, 2005, 20(6): 613-617.

Citation: WEI Zhan-yong, CUI Bao-an, HUANG Ke-he, WANG Xue-bin, PAN Cui-ling, GUO Xiao-quan. Inhibitory Effects of Different Selenium Sources on Porcine Parvovirus Infection in vitro .VIROLOGICA SINICA, 2005, 20(6) : 613-617.

硒对猪细小病毒体外增殖抑制作用的研究

魏战勇 ^1,2 ,
崔保安 ² ,
黄克和 ^1* ,
王学斌 ² ,
潘翠玲 ¹ ,
郭小权 ¹

1.
1.南京农业大学动物医学院江苏南京 2.河南省动物性食品安全重点实验室河南郑州

摘要

本文以PK-15细胞为模型,研究了亚硒酸钠、硒蛋氨酸和海藻硒多糖等三种硒化合物对猪细小病毒体外复制的抑制作用,以及还原型谷胱甘肽、D-甘露醇等氧自由基清除剂对不同来源硒的抑制病毒作用的影响。结果表明: 三种硒化合物对猪细小病毒在PK-15中的复制呈现不同程度的抑制作用,在相同浓度时其强度依次为硒蛋氨酸、亚硒酸钠、海藻硒多糖,随着浓度的增加,其抑制作用逐渐增强,呈剂量依赖性关系。还原型谷胱甘肽和甘露醇均有增强硒的抑制病毒复制作用,两者同时添加时,协同增强硒的抑制病毒复制作用。
- 猪细小病毒
- , 亚硒酸钠
- , 硒蛋氨酸
- , 海藻硒多糖
- , 还原型谷胱甘肽
- , 甘露醇

Inhibitory Effects of Different Selenium Sources on Porcine Parvovirus Infection in vitro

Abstract

Inhibitory effects of sodium selenite, DL-selenomethionine and Kappa-selenocarrag-eenan on Porcine parvovirus (PPV) infection of the PK-15 cells were studied. The influences of reduced glutathione (GSH) and D-mannitol on antiviral effects of selenium were also carried out in PK-15 cells. The results showed that all of the three selenium sources have an inhibitory effect on the PPV replication in vitro. DL-selenomethionine had the highest inhibitory effect while Kap-pa-selenocarrageenan had the lowest, and the inhibition was concentration-dependent. The GSH and D-mannitol have the ability to increase the antiviral effects of selenium. The antiviral effect was enhanced with the addition of both GSH and D-mannitol.
- Porcine parvovirus
- , Sodium selenite
- , Kappa-selenocarrageenan
- , DL-Selenomet hionine
- , Glutathione reduced
- , D-Mannitol

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Inhibitory Effects of Different Selenium Sources on Porcine Parvovirus Infection in vitro

Abstract: Inhibitory effects of sodium selenite, DL-selenomethionine and Kappa-selenocarrag-eenan on Porcine parvovirus (PPV) infection of the PK-15 cells were studied. The influences of reduced glutathione (GSH) and D-mannitol on antiviral effects of selenium were also carried out in PK-15 cells. The results showed that all of the three selenium sources have an inhibitory effect on the PPV replication in vitro. DL-selenomethionine had the highest inhibitory effect while Kap-pa-selenocarrageenan had the lowest, and the inhibition was concentration-dependent. The GSH and D-mannitol have the ability to increase the antiviral effects of selenium. The antiviral effect was enhanced with the addition of both GSH and D-mannitol.