WU En-qi, REN Yuan, QIU Ai-dong, ZHANG Guo-nan, JIANG Chun-lai, YU Xiang-hui, WU Yong-ge, ZHA Xiao and KONG Wei. HPV59 Infection and E6 Gene Mutation from Patients with Cervical Cancer in Sichuan[J]. Virologica Sinica, 2005, 20(6): 673-674.
Citation: WU En-qi, REN Yuan, QIU Ai-dong, ZHANG Guo-nan, JIANG Chun-lai, YU Xiang-hui, WU Yong-ge, ZHA Xiao, KONG Wei. HPV59 Infection and E6 Gene Mutation from Patients with Cervical Cancer in Sichuan .VIROLOGICA SINICA, 2005, 20(6) : 673-674.

四川地区宫颈癌HPV59型感染及其E6基因突变

  • 正宫颈癌是妇科常见的恶性肿瘤,特定型别的人 乳头瘤病毒(HPV)感染是引发宫颈癌的主要因 素。根据HPV致癌性的不同可分为高危型,低 危型。Munoz N[2]等对来自9个国家的1918例宫 颈癌组织进行各型HPV筛查,最终确认HPV-16、 18、26、31、33、35、39、45、51、52、53、56、58、59、66、 68、73及82型为高危型。李洁等[3]用核酸印迹技 术对1986至1994年间来自我国14个省市自治区 的1008宫颈癌组织进行HPV型别检测,发现 HPV-16、18、31、35、51、58等型的存在,并发现各 地区主要流行型别随地理位置有所差异。

HPV59 Infection and E6 Gene Mutation from Patients with Cervical Cancer in Sichuan

  • The development of effective strategies against cervical cancer require knowledge on the prevalence and molecular biology of the Human papillomavirus (HPV). We have investigated HPV infection in 60 women suffering from cervical cancer. HPV was typed by PCR of DNA extracts. The prevalence of cervical HPV 59 infection was 5% (3/60). We also characterized E6 region nucleotide variation by PCR-directed sequencing. 1 of 3 cases showed 4 sites variations (T102C, C306T, A363C and T402C) in E6 region.

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    HPV59 Infection and E6 Gene Mutation from Patients with Cervical Cancer in Sichuan

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    Abstract: The development of effective strategies against cervical cancer require knowledge on the prevalence and molecular biology of the Human papillomavirus (HPV). We have investigated HPV infection in 60 women suffering from cervical cancer. HPV was typed by PCR of DNA extracts. The prevalence of cervical HPV 59 infection was 5% (3/60). We also characterized E6 region nucleotide variation by PCR-directed sequencing. 1 of 3 cases showed 4 sites variations (T102C, C306T, A363C and T402C) in E6 region.

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