ZHAO Hong-xia, XIA Xian-zhu, LU Ji-rong, YANG Song-tao, ZHU Ping and Roles of ICAM-1 and it’s Receptors in HPAIV Pneumonia[J]. Virologica Sinica, 2006, 21(1): 38-42.
Citation: ZHAO Hong-xia, XIA Xian-zhu, LU Ji-rong, YANG Song-tao, ZHU Ping, . Roles of ICAM-1 and it’s Receptors in HPAIV Pneumonia .VIROLOGICA SINICA, 2006, 21(1) : 38-42.

ICAM-1及其受体在高致病性禽流感病毒性肺炎中的作用研究

  • 通讯作者: 夏咸柱, 
  • 本文应用高致病性禽流感病毒性肺炎(Highly pathogenic avian influenza viral pneumonia, HPAIVP)小鼠模型,采用免疫组织化学染色方法,对实验组和对照组小鼠肺组织中ICAM-1及其受体的表达含量进行检测。研究发现:实验组小鼠肺组织中ICAM-1及其受体表达含量在攻毒后1d即开始升高,第4天达高峰。就攻毒剂量来说,以100LD50/50 L攻毒组小鼠肺组织中ICAM-1及其受体阳性表达量升高最明显。并通过ELASA方法进一步证实了这种变化。结果表明:ICAM-1及其受体在HPAIVP中呈现高表达,可能在其发病中发挥了重要作用。

Roles of ICAM-1 and it’s Receptors in HPAIV Pneumonia

  • Corresponding author: XIA Xian-zhu, 
  • The intercellular adhension molecular-1(ICAM-1)and it’s its receptors in the mice’s lungs of HPAIV and control mice pneumonia were detected by using immunohistochemistry staining after infected mice with Highly pathogenic avian influenza virus (HPAIV). The expressive level of ICAM–1, and its receptors of CD11b and CD18 were first detected after 24 hours infection in bronchial alveolar epithelial cells, bronchopulmonary capillary endothelial cells, and iinfiltrativing lymphomonocyte and monocytes, and reached were the peaks 4 days after infection. The highest expression of ICAM-1 and its receptors were detected when infected with 100LD50/50 μL HPAIV. The change was confirmed by the method of ELASA. Our results indicate that ICAM-1 and its receptors have the high expression level in HPAIVP pneumonia, and may play an important roles in the pathogenesis.

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    Roles of ICAM-1 and it’s Receptors in HPAIV Pneumonia

      Corresponding author: XIA Xian-zhu,
    • 1. 1.Institute of Military Veterinary, Academy of Military Medical Science of PLA Changchun 130062, China
    • 2. The First Hospital, Jilin University, Changchun 130061, China

    Abstract: The intercellular adhension molecular-1(ICAM-1)and it’s its receptors in the mice’s lungs of HPAIV and control mice pneumonia were detected by using immunohistochemistry staining after infected mice with Highly pathogenic avian influenza virus (HPAIV). The expressive level of ICAM–1, and its receptors of CD11b and CD18 were first detected after 24 hours infection in bronchial alveolar epithelial cells, bronchopulmonary capillary endothelial cells, and iinfiltrativing lymphomonocyte and monocytes, and reached were the peaks 4 days after infection. The highest expression of ICAM-1 and its receptors were detected when infected with 100LD50/50 μL HPAIV. The change was confirmed by the method of ELASA. Our results indicate that ICAM-1 and its receptors have the high expression level in HPAIVP pneumonia, and may play an important roles in the pathogenesis.

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