Study of Severe Liver Disease in Patients Coinfected with HBV and HCV

XIE Li; LI Xiu-hui; ZHANG Rui-yun; XIN Yong-mei; SHI Hong-bo

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April 2006

XIE Li, LI Xiu-hui, ZHANG Rui-yun, XIN Yong-mei and SHI Hong-bo. Study of Severe Liver Disease in Patients Coinfected with HBV and HCV[J]. Virologica Sinica, 2006, 21(2): 186-188.

Citation: XIE Li, LI Xiu-hui, ZHANG Rui-yun, XIN Yong-mei, SHI Hong-bo. Study of Severe Liver Disease in Patients Coinfected with HBV and HCV .VIROLOGICA SINICA, 2006, 21(2) : 186-188.

慢性肝炎中乙型和丙型病毒混合感染的重症化研究

谢立 ^1*,, ,
李秀惠 ² ,
张瑞云 ² ,
辛咏梅 ³ ,
时红波 ¹

1.
1.首都医科大学附属北京佑安医院肝炎研究所，北京 100069
2.
首都医科大学附属北京佑安医院中西医结合科，北京 100069
3.
首都医科大学附属北京佑安医院临检中心, 北京100069

通讯作者： 谢立, ;

摘要
- 乙型肝炎病毒
- , 丙型肝炎病毒
- , 混合感染

Study of Severe Liver Disease in Patients Coinfected with HBV and HCV

1.
Beijing You-an Hospital affiliated to Capital University of Medical Sciences, Beijing 100069, China

Corresponding author: XIE Li,

Abstract

To understand the dual infection by Hepatitis B virus (HBV) and Hepatitis C virus (HCV), and the viral interference between HBV and HCV infections, biochemical and virological markers of 196 patients were detected. Among 196 patients tested, 76 patients were only infected by HBV, 72 patients were only infected by HCV, and 48 patients were co-infected by HBV and HCV. There were no striking association of ALT in patients with HBV, HCV or co-infection. The positive rate of HBsAg and HBV DNA in patients with co-infection was obviously lower than that of HBV infection only. These results suggested that disease was more severe in patients with co-infection, prevalence of LC and HCC in patients with co-infection was higher than either infection alone. HBV and HCV inhibit the replication with each other, but HCV seems to suppress HBV replication more evidently. Key words：Hepatitis B virus(HBV); Hepatitis C virus(HCV); Co-infection
- Hepatitis B virus(HBV)
- , Hepatitis C virus(HCV)
- , Co-infection

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Study of Severe Liver Disease in Patients Coinfected with HBV and HCV

Corresponding author: XIE Li,

1. Beijing You-an Hospital affiliated to Capital University of Medical Sciences, Beijing 100069, China

Abstract: To understand the dual infection by Hepatitis B virus (HBV) and Hepatitis C virus (HCV), and the viral interference between HBV and HCV infections, biochemical and virological markers of 196 patients were detected. Among 196 patients tested, 76 patients were only infected by HBV, 72 patients were only infected by HCV, and 48 patients were co-infected by HBV and HCV. There were no striking association of ALT in patients with HBV, HCV or co-infection. The positive rate of HBsAg and HBV DNA in patients with co-infection was obviously lower than that of HBV infection only. These results suggested that disease was more severe in patients with co-infection, prevalence of LC and HCC in patients with co-infection was higher than either infection alone. HBV and HCV inhibit the replication with each other, but HCV seems to suppress HBV replication more evidently. Key words：Hepatitis B virus(HBV); Hepatitis C virus(HCV); Co-infection