Immuuological Surey of Canine Distemper in Large Felids in Zoos

LI Mei-rong; TANG Tai-shan; ZHANG Chang-yin; WANG Kai-min; LI Ming-jie; CHEN Jia-qiu; LU Cheng-ping

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August 2006

LI Mei-rong, TANG Tai-shan, ZHANG Chang-yin, WANG Kai-min, LI Ming-jie, CHEN Jia-qiu and LU Cheng-ping. Immuuological Surey of Canine Distemper in Large Felids in Zoos[J]. Virologica Sinica, 2006, 21(4): 368-370.

Citation: LI Mei-rong, TANG Tai-shan, ZHANG Chang-yin, WANG Kai-min, LI Ming-jie, CHEN Jia-qiu, LU Cheng-ping. Immuuological Surey of Canine Distemper in Large Felids in Zoos .VIROLOGICA SINICA, 2006, 21(4) : 368-370.

动物园大型猫科动物犬瘟热的免疫监测

李梅荣 ¹ ,
唐泰山 ² ,
张常印 ² ,
王凯民 ² ,
李明杰 ¹ ,
程家求 ¹ ,
陆承平 ^3*,,

1.
1南京市红山森林动物园, 江苏南京210028
2.
苏出入境检验检疫局, 江苏南京 210001
3.
京农业大学　农业部动物疫病诊断与免疫重点开放实验室, 江苏南京210095

通讯作者： 陆承平,

摘要

虎、狮、豹等大型猫科动物可发生犬瘟热（CD），有必要进行预防。采取某动物园未免疫的东北虎、非洲狮、猞猁血样，用中和试验检测，结果显示这些动物的犬瘟热病毒（CDV）抗体水平均小于1:5。用CD弱毒疫苗接种以上动物，幼龄动物免疫14d逐步产生抗体；成年动物体内抗体水平在两月内迅速升高，并维持在1:64以上，9～11个月后逐步下降，加强免疫后抗体又迅速升高至≥1:112。该疫苗对所有接种的动物均安全可靠。白化的孟加拉虎接种疫苗后不能产生CDV中和抗体。
- 犬瘟热
- , 弱毒疫苗
- , 猫科动物
- , 免疫
- , 中和试验

Immuuological Surey of Canine Distemper in Large Felids in Zoos

1.
1.Nanjing Forest Zoo, Nanjing 210028, China
2.
Jiangsu Entry-Exit Inspection and Quarantine Bureau, Nanjing 210001, China
3.
Key Lab of Animal Disaese Diagnostic & Immunology, Ministry of Agriculture, Nanjing Agricultural University, Nanjing 210095, China

Corresponding author: LU Cheng-ping,

Abstract

Large felids, such as tigers, lions and leopards are often infected with Canine Distemper (CD). Blood samples from pre-immune Amur tiger, African lion and lynx were collected and the antibody against CDV was measured by neutralization tests. The results showed that their CDV antibody level were all below 1:5. After inoculated with attenuated CD vaccine, the young animals produced antibody in 14 days but the antibody levels of the adults increased rapidly within two months and maintained at titer of 1: 64, then gradually dropped after 9 to 11 months. After booster immunizing, antibody level went up rapidly to≥1:112. The vaccination was safe to the animals. Achroia Indian tiger, however, could not produce CDV neutralizing antibody after vaccination.
- Canine Distemper
- , Attenuated Vaccine
- , Felids
- , Immune Surveillance
- , Neutralization Test

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Immuuological Surey of Canine Distemper in Large Felids in Zoos

Corresponding author: LU Cheng-ping,

1. 1.Nanjing Forest Zoo, Nanjing 210028, China
2. Jiangsu Entry-Exit Inspection and Quarantine Bureau, Nanjing 210001, China
3. Key Lab of Animal Disaese Diagnostic & Immunology, Ministry of Agriculture, Nanjing Agricultural University, Nanjing 210095, China

Abstract: Large felids, such as tigers, lions and leopards are often infected with Canine Distemper (CD). Blood samples from pre-immune Amur tiger, African lion and lynx were collected and the antibody against CDV was measured by neutralization tests. The results showed that their CDV antibody level were all below 1:5. After inoculated with attenuated CD vaccine, the young animals produced antibody in 14 days but the antibody levels of the adults increased rapidly within two months and maintained at titer of 1: 64, then gradually dropped after 9 to 11 months. After booster immunizing, antibody level went up rapidly to≥1:112. The vaccination was safe to the animals. Achroia Indian tiger, however, could not produce CDV neutralizing antibody after vaccination.