H and N Gene Variation Rate of Measles Virus Strain in China

LI Hai-feng; LU Yi-yu; YAN Ju-ying; XIA Zhe-zhi; ZOU yan; XU Chang-ping; FENG yan

PDF
Cite
Share

facebook

twitter

google

linkedin

December 2006

LI Hai-feng, LU Yi-yu, YAN Ju-ying, XIA Zhe-zhi, ZOU yan, XU Chang-ping and FENG yan. H and N Gene Variation Rate of Measles Virus Strain in China[J]. Virologica Sinica, 2006, 21(6): 541-545.

Citation: LI Hai-feng, LU Yi-yu, YAN Ju-ying, XIA Zhe-zhi, ZOU yan, XU Chang-ping, FENG yan. H and N Gene Variation Rate of Measles Virus Strain in China .VIROLOGICA SINICA, 2006, 21(6) : 541-545.

我国麻疹病毒流行株的H和N基因变异速率探讨

李海峰 ¹ ,
卢亦愚 ^, ,
严菊英 ² ,
夏哲智 ¹ ,
徐昌平 ² ,

1.
1.浙江大学医学院附属儿童医院，浙江杭州，310003
2.
浙江省疾病预防控制中心，浙江杭州, 310009

通讯作者： 卢亦愚, ;

摘要

从GenBank检索并下载了我国近40年的麻疹病毒血凝素蛋白(H)和核蛋白(N)的全基因组序列，用Bioedit7.0软件对参考株和代表株进行序列比对，并进行氨基酸进化树的构建，进一步从氨基酸层面分析麻疹流行株的变化速率。结果显示麻疹病毒H蛋白发生的变异，表现为近十年的变异率(1.3310-3)大约为前三十年变异率(0.9510-3)的1.4倍，而N蛋白发生的变异，表现为近些年的变异率(1.9010-3)大约为前三十年变异率(1.0110-3)的1.8倍。本研究结果提示麻疹病毒近年变异率有增快的趋势，今后需加强对麻疹病毒基因型变异和演变的监测。
- 麻疹
- , 基因
- , 变异速率

H and N Gene Variation Rate of Measles Virus Strain in China

1.
1. The Affiliated Children Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, China
2.
Zhejiang Center for Disease Prevention and Control, Hangzhou, Zhejiang, 310009, China

Corresponding author: LU Yi-yu,

Abstract

The gene sequences of the Hemagglutinin and Nucleoprotein were downloaded from GenBank. Bioedit7.0 softwere was used to pairwise these sequences and to construct a phylogenetic tree to analyze the variation rate of measles virus strains. The results demonstrated that variation rate of hemagglutinin gene was 1.3310-3 in the recent 10 years, which was about 1.4-fold higher than in the former 30 years. The variation rate of nucleoprotein gene was 1.9010-3 in the recent 10 years, which was about 1.8-fold higher than in the former 30 years. These findings suggest that monitoring the variation of measles virus should be emphasized because of the increasing variation rate in the recent 10 years.
- Measles
- , Gene
- , Variation rate

References
Proportional views

PDF

Article Metrics

Article views(4521) PDF downloads(1144) Cited by(0)

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

H and N Gene Variation Rate of Measles Virus Strain in China

Corresponding author: LU Yi-yu,

1. 1. The Affiliated Children Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, China
2. Zhejiang Center for Disease Prevention and Control, Hangzhou, Zhejiang, 310009, China

Abstract: The gene sequences of the Hemagglutinin and Nucleoprotein were downloaded from GenBank. Bioedit7.0 softwere was used to pairwise these sequences and to construct a phylogenetic tree to analyze the variation rate of measles virus strains. The results demonstrated that variation rate of hemagglutinin gene was 1.3310-3 in the recent 10 years, which was about 1.4-fold higher than in the former 30 years. The variation rate of nucleoprotein gene was 1.9010-3 in the recent 10 years, which was about 1.8-fold higher than in the former 30 years. These findings suggest that monitoring the variation of measles virus should be emphasized because of the increasing variation rate in the recent 10 years.