Functional Analysis of SR-15 Protein of Human Fibroblast  Induced by HSVⅠInfection

JIANG Li #; LI Pin-Zhong #; DONG Cheng-Hong; LI Qi-Han

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December 2006

JIANG Li #, LI Pin-Zhong #, DONG Cheng-Hong and LI Qi-Han. Functional Analysis of SR-15 Protein of Human Fibroblast Induced by HSVⅠInfection[J]. Virologica Sinica, 2006, 21(6): 546-550.

Citation: JIANG Li #, LI Pin-Zhong #, DONG Cheng-Hong, LI Qi-Han. Functional Analysis of SR-15 Protein of Human Fibroblast Induced by HSVⅠInfection .VIROLOGICA SINICA, 2006, 21(6) : 546-550.

HSVⅠ感染人成纤维细胞诱导的SR-15蛋白生物学功能分析

1.
中国医学科学院/中国协和医科大学医学生物学研究所，昆明 650118

通讯作者： 李琦涵,

摘要

人单纯疱疹病毒Ⅰ型（Herpes simplex virusⅠ, HSVⅠ）结合人成纤维细胞相应受体以启动感染的过程，能够引起细胞产生特异性蛋白分子的表达，其中之一的SR-15蛋白经酵母双杂交系统分析证明可与细胞内多个具有KRAB结构的锌指蛋白产生特异性相互作用，其作用部位为锌指结构域，该作用能够影响该类蛋白之一ZNF268在细胞内的转录抑制作用。
- HSVⅠ
- , SR-15
- , 相互作用
- , 锌指蛋白

Functional Analysis of SR-15 Protein of Human Fibroblast Induced by HSVⅠInfection

1.
Institute of Medical Biology, Chinese Academy of Medical Science /Peking Union Medical College, Kunming 650118, China

Corresponding author: LI Qi-Han,

Abstract

The binding of HSVⅠ to receptors of human fibroblast initiates viral infection and induces the cells to express specific proteins. SR-15, one of these proteins, was identified to interact with certain zinc finger proteins containing KRAB domain through binding zinc finger domain in yeast trap system. This interaction impacts the transcriptional repression of ZNF268, which is one of this type of zinc finger proteins in cells.
- Herpes simplex virus Ⅰ(HSVⅠ)
- , SR-15
- , Interaction
- , Zinc finger protein

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Functional Analysis of SR-15 Protein of Human Fibroblast Induced by HSVⅠInfection

Corresponding author: LI Qi-Han,

1. Institute of Medical Biology, Chinese Academy of Medical Science /Peking Union Medical College, Kunming 650118, China

Abstract: The binding of HSVⅠ to receptors of human fibroblast initiates viral infection and induces the cells to express specific proteins. SR-15, one of these proteins, was identified to interact with certain zinc finger proteins containing KRAB domain through binding zinc finger domain in yeast trap system. This interaction impacts the transcriptional repression of ZNF268, which is one of this type of zinc finger proteins in cells.