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Serving the Society Since 1986
Focused Topic "Hemorrhagic Fever Viruses"
Editor(s): Zhihong Hu: PhD, Professor, Wuhan Institute of Virology; Jens H Kuhn, PhD, Professor, National Institute of Allergy and Infectious Diseases, NIH
Viral hemorrhagic fevers are caused by several distinct families of RNA and DNA viruses that can cause devastating disease in humans and other animals. Hemorrhagic fever viruses usually reside in animal or arthropod hosts and transmit to humans, resulting in human outbreak. Four major families of HFVs are Arenaviridae, Filoviridae, Bunyaviridae, and Flaviviridae. This special Issue presents the recent progress on Ebola virus, dengue virus, hantavirus, Crimean-Congo hemorrhagic fever virus, severe fever with thrombocytopenia syndrome virus, and covers topics on viral epidemiology, viral pathogenesis, and virus-host cell interaction of those hemorrhagic fever viruses. The cover depicts the hemorrhagic fever viruses and their major hosts.
  • 一株从中国新疆分离的克里米亚刚果出血热病毒新毒株

    郭荣, 沈姝, 张艳芳, 史君明, 苏正元, 刘丹, 刘金良, 杨娟, 王启果, 张渝疆, 邓菲,

    2017, 32(1): 80 doi: 10.1007/s12250-016-3936-9

    收稿日期: 2016-12-21 录用日期: 2017-02-20 出版日期: 2017-02-27
    [HTML全文] [PDF 13378 KB] Springerlink
    Crimean-Congo hemorrhagic fever virus (CCHFV) is a highly pathogenic tick-borne virus with a fatality rate of up to 50% in humans. CCHFV is widely distributed in countries around the world. Outbreaks of CCHFV infection in humans have occurred in prior years in Xinjiang Province, China. Epidemiological surveys have detected CCHFV RNA in ticks and animals; however, few isolates were identified. In this study, we identified and isolated a new CCHFV strain from Hyalomma asiaticum asiaticum ticks collected from north of Tarim Basin in Xinjiang, China. A preliminary investigation of infection and antigens expression of CCHFV was performed in newborn mice. The target tissues for CCHFV replication in newborn mice were identified. The analysis of the phylogenetic relationships with other Chinese strains suggested that diverse genotypes of CCHFV have circulated in Xinjiang for years. These findings provide important insights into our understanding of CCHFV infection and evolution as well as disease prevention and control for local residents.
  • 发热伴血小板减少综合征在中国的当前现状

    占建波, 王芹, 程静, 胡兵, 李静, 占发先, 宋毅, 郭德银

    2017, 32(1): 51 doi: 10.1007/s12250-016-3931-1

    收稿日期: 2016-12-12 录用日期: 2017-02-20 出版日期: 2017-02-27
    [HTML全文] [PDF 8875 KB] Springerlink
    Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by SFTS virus (SFTSV). SFTSV is associated with a high mortality rate and has been reported in China, South Korea and Japan. SFTSV undergoes rapid changes owing to evolution, gene mutations, and reassortment between different strains of SFTSV. In this review, we summarize the recent cases and general properties of SFTS, focusing on the epidemiology, genetic diversity, clinical features, and diagnostics of SFTSV in China. From 2010 to October 2016, SFTS cases were reported in 23 provinces of China, with increased numbers yearly. Infection and death cases are mainly found in central China, where the Haemaphysalis longicornis ticks are spread. The national average mortality rate of SFTS infection was 5.3%, with higher risk to elder people. The main epidemic period was from May to July, with a peak in May. Thus, SFTS reminds a significant public health problem, and development of prophylactic vaccines and effective antiviral drugs will be highly needed.
  • From the new Editor-in-Chief

    Zheng-Li Shi

    2017, 32(1): 1 doi: 10.1007/s12250-017-3963-1

    出版日期: 2017-02-27
    [HTML全文] [PDF 3802 KB] Springerlink
    It is both an honor and pleasure to have been appointed as the Editor-in-Chief of the journal Virologica Sinica from this volume. Professor Xinwen CHEN, who has dedicated to serve the journal as the Editor-in-Chief for 15 years, concluded his term of service in the last volume. I would like to thank Prof.
  • 三株来自中国湖北省的发热伴血小板减少综合征病毒新毒株的分离、特性研究和进化分析

    张艳芳, 沈姝, 史君明, 苏正元, 李明月, 张文静, 李蒙蒙, 胡志红, 彭程, 郑昕, 邓菲

    2017, 32(1): 89 doi: 10.1007/s12250-017-3953-3

    收稿日期: 2017-02-06 录用日期: 2017-02-20 出版日期: 2017-02-24
    [HTML全文] [PDF 6233 KB] Springerlink
    Hubei Province is a major epidemic area of severe fever with thrombocytopenia syndrome bunyavirus (SFTSV) in China. However, to date, a few SFTSV strains have been isolated from Hubei Province, preventing effective studies of epidemic outbreaks. Here, we report three confirmed patients (2015-2016) with typical symptoms of severe fever with thrombocytopenia syndrome disease (SFTS) who were farmers resident in different regions in Hubei Province. Three new SFTSV strains were isolated from the serum samples of each patient. Characterization of viral growth properties showed that there were no significant differences in virus production. All strains were completely sequenced, and phylogenetic analysis showed that unlike the other strains from Hubei province, which belonged to the SFTSV C3 genotype, one of the three strains belonged to the SFTSV C2 genotype. These results suggested that multiple SFTSV genotypes have been circulating in Hubei Province, providing insights into SFTSV evolution and improving our understanding of SFTSV prevalence in Hubei Province.
  • 登革病毒复制相关宿主因子的最新研究进展

    汪义, 张萍

    2017, 32(1): 23 doi: 10.1007/s12250-016-3902-6

    收稿日期: 2016-11-03 录用日期: 2017-01-04 出版日期: 2017-01-24
    [HTML全文] [PDF 358 KB] Springerlink
    Dengue virus (DENV) belongs to the genus Flavivirus of the family Flaviviridae and it is primarily transmitted via Aedes aegypti and Aedes albopictus mosquitoes. The life cycle of DENV includes attachment, endocytosis, protein translation, RNA synthesis, assembly, egress, and maturation. Recent researches have indicated that a variety of host factors, including cellular proteins and microRNAs, positively or negatively regulate the DENV replication process. This review summarizes the latest findings (from 2014 to 2016) in the identification of the host factors involved in the DENV life cycle and Dengue infection.
  • 发热伴血小板减少综合症布尼亚病毒核衣壳蛋白的抗原性及其在血清学诊断中的潜在应用

    阿布力米提, 莫明, 张渝疆, 常晨晨, 俞欢, 汪梅芳, 胡志红, 邓菲

    2017, 32(1): 97 doi: 10.1007/s12250-016-3928-9

    出版日期: 2017-01-23
    [HTML全文] [PDF 5935 KB] Springerlink
    Dear Editor, Severe fever with thrombocytopenia syndrome virus (SFTSV) is a newly identified viral pathogen of the genus Phlebovirus in the family Bunyaviridae (Sun et al., 2012). SFTSV was first identified from patient serum samples in China (Li et al., 2013; Ning et al., 2015).
  • 分子流行病学研究结果显示输入株和本地株在2014年广州登革大暴发时共流行

    李耿, 潘攀, 孔秀娟, 邬开朗, 张威, 刘云涛, 黄慧婷, 刘建博, 张仲德, 吴德, 赖小平, 刘小虹, 吴建国,

    2017, 32(1): 63 doi: 10.1007/s12250-016-3872-8

    收稿日期: 2016-09-18 录用日期: 2016-11-15 出版日期: 2017-01-23
    [HTML全文] [PDF 722 KB] Springerlink
    The dengue virus (DENV) is a vital global public health issue. The 2014 dengue epidemic in Guangzhou, China, caused approximately 40,000 cases of infection and five deaths. We carried out a comprehensive investigation aimed at identifying the transmission sources in this dengue epidemic. To analyze the phylogenetics of the 2014 dengue strains, the envelope (E) gene sequences from 17 viral strains isolated from 168 dengue patient serum samples were sequenced and a phylogenetic tree was reconstructed. All 17 strains were serotype I strains, including 8 genotype I and 9 genotype V strains. Additionally, 6 genotype I strains that were probably introduced to China from Thailand before 2009 were widely transmitted in the 2013 and 2014 epidemics, and they continued to circulate until 2015, with one affinis strain being found in Singapore. The other 2 genotype I strains were introduced from the Malaya Peninsula in 2014. The transmission source of the 9 genotype V strains was from Malaysia in 2014. DENVs of different serotypes and genotypes co-circulated in the 2014 dengue outbreak in Guangzhou. Moreover, not only had DENV been imported to Guangzhou, but it had also been gradually exported, as the viruses exhibited an enzootic transmission cycle in Guangzhou.
  • 汉坦病毒感染:全球动物疫源性疾病的威胁

    姜泓, 郑煦暘, 王丽梅, 杜虹, 王平忠, 白雪帆

    2017, 32(1): 32 doi: 10.1007/s12250-016-3899-x

    收稿日期: 2016-10-28 录用日期: 2017-01-05 出版日期: 2017-01-13
    [HTML全文] [PDF 2289 KB] Springerlink
    Hantaviruses are comprised of tri-segmented negative sense single-stranded RNA, and are members of the Bunyaviridae family. Hantaviruses are distributed worldwide and are important zoonotic pathogens that can have severe adverse effects in humans. They are naturally maintained in specific reservoir hosts without inducing symptomatic infection. In humans, however, hantaviruses often cause two acute febrile diseases, hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS). In this paper, we review the epidemiology and epizootiology of hantavirus infections worldwide.
  • 发热伴血小板减少综合征病毒的进入机制

    袁菲, 郑爱华

    2017, 32(1): 44 doi: 10.1007/s12250-016-3858-6

    收稿日期: 2016-08-28 录用日期: 2016-11-30 出版日期: 2016-12-16
    [HTML全文] [PDF 3003 KB] Springerlink
    Severe fever with thrombocytopenia syndrome virus (SFTSV) is a globe-shaped virus covered by a dense icosahedral array of glycoproteins Gn/Gc that mediate the attachment of the virus to host cells and the fusion of viral and cellular membranes. Several membrane factors are involved in virus entry, including C-type lectins and nonmuscle myosin heavy chain IIA. The post-fusion crystal structure of the Gc protein suggests that it is a class II membrane fusion protein, similar to the E/E1 protein of flaviviruses and alphaviruses. The virus particles are internalized into host cell endosomes through the clathrin-dependent pathway, where the low pH activates the fusion of the virus with the cell membrane. With information from studies on other bunyaviruses, herein we will review our knowledge of the entry process of SFTSV.
  • 登革出血热发病机制研究进展

    庞晓静, 张入典, 程功

    2017, 32(1): 16 doi: 10.1007/s12250-016-3855-9

    收稿日期: 2016-08-22 录用日期: 2016-10-12 出版日期: 2016-11-14
    [HTML全文] [PDF 540 KB] Springerlink
    Dengue virus (DENV) is a mosquito-borne virus belonging to the Flaviviridae family. There are 4 serotypes of DENV that cause human disease through transmission by mosquito vectors. DENV infection results in a broad spectrum of clinical symptoms, ranging from mild fever to dengue hemorrhagic fever (DHF), the latter of which can progress to dengue shock syndrome (DSS) and death. Researchers have made unremitting efforts over the last half-century to understand DHF pathogenesis. DHF is probably caused by multiple factors, such as virus-specific antibodies, viral antigens and host immune responses. This review summarizes the current progress of studies on DHF pathogenesis, which may provide important information for achieving effective control of dengue in the future.
  • 湖北地区汉族人群中整合素αvβ3基因单核苷酸多态性与汉坦病毒感染肾综合征出血热的关联性研究

    陈小平, 熊海蓉, 朱薿, 陈清宙, 王辉, 钟超洁, 王美蓉, 卢霜, 罗凡, 侯炜

    2017, 32(1): 73 doi: 10.1007/s12250-016-3888-0

    收稿日期: 2016-10-09 录用日期: 2017-01-04 出版日期: 2016-10-18
    [HTML全文] [PDF 592 KB] Springerlink
    Hantaviruses belong to the family Bunyaviridae and cause hemorrhagic fever with renal syndrome (HFRS) in humans. β3 integrins, including αVβ3 and αIIbβ3 integrins, act as receptors on endothelial cells and play key roles in cellular entry during the pathogenesis of hantaviruses. Previous study demonstrated that the polymorphisms of integrin αIIbβ3 are associated with susceptibility to hantavirus infection and the disease severity of HFRS in Shaanxi Province of China, rather than in Finland. However, the polymorphisms of integrin αvβ3 in patients with HFRS was incompletely understood. Here, we aimed to investigate the associations between polymorphisms in human integrin αvβ3 and HFRS in Han Chinese individuals. Ninety patients with HFRS and 101 healthy controls were enrolled in this study. Analysis of five single nucleotide polymorphism (SNP) sites (rs3768777 and rs3738919 on ITGAV; rs13306487, rs5921, and rs5918 on ITGB3) was performed by TaqMan SNP genotyping assays and bi-directional PCR allele-specific amplification method. No significant differences were observed between the HFRS group and controls regarding the genotype and allele frequency distributions of any of the five SNP sites, and no associations were found between ITGAV polymorphisms/genotypes and disease severity. In conclusion, our results implied that these five SNPs in the integrin αvβ3 gene were not associated with HFRS susceptibility or severity in Han Chinese individuals in Hubei Province.
36卷第6期 (2021年12月)

ISSN 1674-0769

EISSN 1995-820X

CN 42-1760/Q

主编: 石正丽

影响因子: 4.327*


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