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Group C Group D Group E Subjects, n 50 32 30 Vaccine PVRV PCECV PVRV Regimen Zagreb Zagreb Essen Injection D0 (2 doses), D7, D21 D0 (2 doses), D7, D21 D0, D3, D7, D14, D28 D, day; PCECV, purified chick embryo cell vaccine; PVRV, purified Vero cell rabies vaccine. Group C: PVRV, Zagreb regimen; group D: PCECV, Zagreb regimen; group E: PVRV, Essen regimen. Table 1. Comparison between different vaccines and regimens.
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Unimmunized sera (n=40) Immunized sera (n=45) Negative 40 (0.01-0.1) 0 Positive 0 45 (0.63-461.67) Data are given as mean (range) in IU/mL. Table 2. Results of the specificity by RFFIT method.
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Sample number Results, IU/mL GMT, IU/mL Standard deviation CV a b c 1 24.48 26.25 19.7 23.31 3.39 14.54 2 2.72 2.98 2.2 2.61 0.40 15.32 3 4.15 3.61 4.1 3.95 0.30 7.50 4 1.57 2.03 1.7 1.76 0.24 13.64 5 0.15 0.25 0.1 0.16 0.08 50 6 1.34 1.52 1.6 1.48 0.13 8.78 7 0.99 0.94 1 0.98 0.03 3.06 8 0.7 1.63 1.2 1.11 0.47 42.34 9 32.5 30 28 30.11 2.25 7.47 10 4.8 4 3.9 4.21 0.49 11.64 11 7.5 7.8 9 8.07 0.79 9.79 12 70 65.8 76.2 70.54 5.23 7.41 13 17.35 18 17.8 17.71 0.33 1.86 14 9.2 7.38 8.9 8.45 0.98 11.48 15 8.5 10.7 10.2 9.75 1.15 11.79 CV, coefficient of variation; GMT, geometric mean titer. Table 3. Results of the repeatability of RFFIT method.
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Day Group Subjects, n GMT, U/mL Ranges 95% CI, IU/mL N≥0.5 IU/mL Seroconversion, % 0 C 50 0.032 0.01-0.06 0.03-0.04 0 0 D 32 0.029 0.01-0.06 0.03-0.04 0 0 E 30 0.030 0.01-0.06 0.03-0.04 0 0 7 C 50 1.36 0.01-28.75 1.93-5.38 46 92 D 31 0.55 0.01-62.96 1.18-10.75 22 70.97 E 29 1.15 0.11-37.43 0.26-6.05 25 86.21 14 C 50 31.59 6.93-637.42 22.73-72.72 50 100 D 29 34.63 6.90-452.20 28.93-102.86 29 100 E 27 26.13 8.26-123.45 22.12-43.48 27 100 45 C 48 18.27 3.41-125.29 17.19-125.29 48 100 D 31 12.67 2.30-243.75 11.49-47.98 31 100 E 26 26.43 6.18-92.68 23.80-42.92 26 100 CV, coefficient of variation; GMT, geometric mean titer; PCECV, purified chick embryo cell vaccine; PVRV, purified Vero cell rabies vaccine. Group C: PVRV, Zagreb regimen; group D: PCECV, Zagreb regimen; group E: PVRV, Essen regimen. Table 4. Results of different vaccines and different regimens.
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Table 4 个