Figure 2个  Table 4
    • Group CGroup DGroup E
      Subjects, n503230
      VaccinePVRVPCECVPVRV
      RegimenZagrebZagrebEssen
       InjectionD0 (2 doses), D7, D21D0 (2 doses), D7, D21D0, D3, D7, D14, D28
      D, day; PCECV, purified chick embryo cell vaccine; PVRV, purified Vero cell rabies vaccine. Group C: PVRV, Zagreb regimen; group D: PCECV, Zagreb regimen; group E: PVRV, Essen regimen.

      Table 1.  Comparison between different vaccines and regimens.

    • Unimmunized sera (n=40)Immunized sera (n=45)
      Negative40 (0.01-0.1)0
      Positive045 (0.63-461.67)
      Data are given as mean (range) in IU/mL.

      Table 2.  Results of the specificity by RFFIT method.

    • Sample numberResults, IU/mLGMT, IU/mLStandard deviationCV
      abc
      124.4826.2519.723.313.3914.54
      22.722.982.22.610.4015.32
      34.153.614.13.950.307.50
      41.572.031.71.760.2413.64
      50.150.250.10.160.0850
      61.341.521.61.480.138.78
      70.990.9410.980.033.06
      80.71.631.21.110.4742.34
      932.5302830.112.257.47
      104.843.94.210.4911.64
      117.57.898.070.799.79
      127065.876.270.545.237.41
      1317.351817.817.710.331.86
      149.27.388.98.450.9811.48
      158.510.710.29.751.1511.79
      CV, coefficient of variation; GMT, geometric mean titer.

      Table 3.  Results of the repeatability of RFFIT method.

    • DayGroupSubjects, nGMT, U/mLRanges95% CI, IU/mLN≥0.5 IU/mLSeroconversion, %
      0C500.0320.01-0.060.03-0.0400
      D320.0290.01-0.060.03-0.0400
      E300.0300.01-0.060.03-0.0400
      7C501.360.01-28.751.93-5.384692
      D310.550.01-62.961.18-10.752270.97
      E291.150.11-37.430.26-6.052586.21
      14C5031.596.93-637.4222.73-72.7250100
      D2934.636.90-452.2028.93-102.8629100
      E2726.138.26-123.4522.12-43.4827100
      45C4818.273.41-125.2917.19-125.2948100
      D3112.672.30-243.7511.49-47.9831100
      E2626.436.18-92.6823.80-42.9226100
      CV, coefficient of variation; GMT, geometric mean titer; PCECV, purified chick embryo cell vaccine; PVRV, purified Vero cell rabies vaccine. Group C: PVRV, Zagreb regimen; group D: PCECV, Zagreb regimen; group E: PVRV, Essen regimen.

      Table 4.  Results of different vaccines and different regimens.