Figure 3个  Table 4
    • Throat swab, antigen detection Result Throat swab, nucleic acid detection Result Serum, antibody detection (IgM) Result Serum, nucleic acid detection Result
      Influenza A virus Negative Influenza A virus, H7-RNA Negative Legionella pneumophila serum type 1 Negative Cytomegalovirus, DNA < 5.00E+2
      Minimal detection limit 5.00E+02
      Influenza B virus Negative Influenza A virus, N9-RNA Negative Mycoplasma pneumoniae Negative EB virus, DNA < 5.00E+3
      Minimal detection limit 5.00E+03
      Adenovirus Negative Influenza A virus, RNA Negative Q fever Rickettsia Negative
      Respiratory syncytial virus Negative Influenza A virus H1N1, RNA Negative Chlamydia pneumonia Negative
      Parainfluenza virus (type 1) Negative Influenza A virus H3N2, RNA Negative Adenovirus Negative
      Parainfluenza virus (type 2) Negative Influenza B virus, RNA Negative Respiratory syncytial virus Negative
      Parainfluenza virus (type 3) Negative Parainfluenza virus, RNA Negative Influenza A virus Negative
      Respiratory syncytial virus, RNA Negative Influenza B virus Negative
      Metapneumovirus, RNA Negative Parainfluenza virus type 1/2/3 Negative
      SARS coronavirus, RNA Negative
      Rhinovirus, RNA Negative
      Adenovirus, DNA Negative
      Bocaparvovirus, DNA Negative
      Pneumonia mycoplasma, DNA Negative
      Pneumonia chlamydia, DNA Negative

      Table 1.  Laboratory tests for known pathogens of the male patient.

    • Laboratory indices Dec. 28, 2019 Dec. 31, 2019 Jan. 3, 2020 Jan. 10, 2020 Normal range
      Total white cells (× 109/L) 2.11 ↓ 2.88 ↓ 2.87 ↓ 4.10 3.5–9.5
      Neutrophils (× 109/L) 0.99 ↓ 2.15 ↓ 1.50 ↓ 1.93 1.8–6.3
      Lymphocytes (× 109/L) 0.89 ↓ 0.49 ↓ 0.92 ↓ 1.57 1.1–3.2
      Monocytes (× 109/L) 0.23 0.24 0.42 0.50 0.1–0.6
      Eosinophils (× 109/L) 0 0 0.02 0.07 0.02–0.52
      C-reactive protein (CRP) (mg/L) 35.43 ↑ 121 ↑ 41.17 ↑ < 0.5 0–10
      Serum amyloid A (SAA) (mg/L) 82.77 ↑ 153 ↑ 52.62 ↑ < 5.00 < 10
      CD3 (/μL) 273 ↓ 723–2737
      CD4 (/μL) 145 ↓ 404–1612
      CD8 (/μL) 114 ↓ 220–1129
      CD19 (/μL) 52 ↓ 80–616
      CD 16 + 56 (/μL) 104 ↓ 84–724
      IgG (g/L) 6.26 ↓ 8–16
      IgM (g/L) Normal 0.4–3.45
      IgA (g/L) Normal 0.76–3.9
      IgE (g/L) Normal < 100
      C3 (g/L) Normal 0.81–1.6
      C4 (g/L) Normal 0.1–0.4
      Chief complaints of the patient The fever subsided, but the patient still had cough, chest distress, and dyspnea The patient had no fever, and the cough, chest distress, and dyspnea were slightly improved The symptoms were improved The patient complained of no discomforts

      Table 2.  A summary report of serial blood tests of the male patient, and the chief complains of the patient.

    • Laboratory indices Dec. 31, 2019 Jan. 3, 2020 Jan. 5, 2020 Jan. 8, 2020 Jan. 10, 2020 Normal range
      Total white cells (× 109/L) 2.83 ↓ 2.41 ↓ 1.58 ↓ 6.29 7.54 3.5–9.5
      Neutrophils (× 109/L) 2.07 1.47 ↓ 0.89 ↓ 4.10 6.06 1.8–6.3
      Lymphocytes (× 109/L) 0.55 ↓ 0.75 ↓ 0.60 ↓ 1.79 1.07 1.1–3.2
      Monocytes (× 109/L) 0.21 0.19 0.09 ↓ 0.39 0.40 0.1–0.6
      Eosinophils (× 109/L) 0 ↓ 0 ↓ 0 ↓ 0 ↓ 0 ↓ 0.02–0.52
      C-reactive protein (CRP) (mg/L) 19.94 ↑ 10.50 ↑ 25.4 ↑ < 0.5 < 0.5 0–10
      Serum amyloid A (SAA)(mg/L) 47.54 ↑ 77.24 ↑ > 300 ↑ 20.52 < 5.00 < 10
      CD3 (/μL) 383 ↓ 290 ↓ 1403 723–2737
      CD4 (/μL) 176 ↓ 122 ↓ 826 404–1612
      CD8 (/μL) 182 ↓ 142 ↓ 537 220–1129
      CD19 (/μL) 41 ↓ 79 ↓ 326 80–616
      CD 16 + 56 (/μL) 23 ↓ 42 ↓ 26 ↓ 84–724
      IgG (g/L) Normal Normal Normal 8–16
      IgM (g/L) Normal Normal Normal 0.4–3.45
      IgA (g/L) Normal Normal Normal 0.76–3.9
      IgE (g/L) Normal Normal Normal < 100
      C3 (g/L) Normal Normal 0.728 ↓ 0.81–1.6
      C4 (g/L) Normal Normal 0.063 ↓ 0.1–0.4
      Chief complaints of the patient Fever, cough, and vomiting Still fever, cough, and diarrhea (passing watery stools) The fever subsided, the diarrhea disappeared, and the cough lasted The fever and diarrhea disappeared, and the cough was improved The patient complained of no discomforts

      Table 3.  A summary report of serial blood tests of the female patient, and the chief complains of the patient.

    • IgM Cut-off value IgG Cut-off value
      Male patient 0.530 ≥ 0.2 1.770 ≥ 0.15
      Female patient 1.645 ≥ 0.2 1.433 ≥ 0.15

      Table 4.  Coronavirus IgM and IgG detection in patients