• Augello, G., Modica, M., Azzolina, A., Puleio, R., Cassata, G., Emma, M.R., Di Sano, C., Cusimano, A., Montalto, G., Cervello, M., 2018. Preclinical evaluation of antitumor activity of the proteasome inhibitor MLN2238 (ixazomib) in hepatocellular carcinoma cells. Cell Death Dis. 9, 28.

  • Avsic-Zupanc, T., Saksida, A., Korva, M., 2019. Hantavirus infections. Clin. Microbiol. Infect. 21S, e6–e16.

  • Baba, M., Okamoto, M., Kashiwaba, N., Ono, M., 2001. Anti-HIV-1 activity and structureactivity relationship of cepharanoline derivatives in chronically infected cells. Antivir. Chem. Chemother. 12, 307–312.

  • Bailly, C., 2019. Cepharanthine: an update of its mode of action, pharmacological properties and medical applications. Phytomedicine 62, 152956.

  • Basu, A., Li, B., Mills, D.M., Panchal, R.G., Cardinale, S.C., Butler, M.M., Peet, N.P., Majgier-Baranowska, H., Williams, J.D., Patel, I., Moir, D.T., Bavari, S., Ray, R., Farzan, M.R., Rong, L., Bowlin, T.L., 2011. Identification of a small-molecule entry inhibitor for filoviruses. J. Virol. 85, 3106–3119.

  • Brocato, R.L., Hooper, J.W., 2019. Progress on the prevention and treatment of hantavirus disease. Viruses 11, 610.

  • Cho, J., Yi, H., Jang, E.Y., Lee, M.S., Lee, J.Y., Kang, C., Lee, C.H., Kim, K., 2017. Mycophenolic mofetil, an alternative antiviral and immunomodulator for the highly pathogenic avian influenza H5N1 virus infection. Biochem. Biophys. Res. Commun. 494, 298–304.

  • Diamond, M.S., Zachariah, M., Harris, E., 2002. Mycophenolic acid inhibits dengue virus infection by preventing replication of viral RNA. Virology 304, 211–221.

  • Engur-Ozturk, S., Dikmen, M., 2022. Proteasome inhibitor immunotherapy for the epithelial to mesenchymal transition: assessing the A549 lung cancer cell microenvironment and the role of M1, M2a and M2c ‘hydrocortisone-polarised’ macrophages. Mol. Biol. Rep. https://doi.org/10.1007/s11033-022-07329-w.

  • Enserink, M., 2014. Infectious diseases. Debate erupts on ‘repurposed’ drugs for Ebola. Science 345, 718–719.

  • Grad, I., Hanes, R., Ayuda-Duran, P., Kuijjer, M.L., Enserink, J.M., Meza-Zepeda, L.A., Myklebost, O., 2021. Discovery of novel candidates for anti-liposarcoma therapies by medium-scale high-throughput drug screening. PLoS One 16, e0248140.

  • Hong, L., Guo, Z., Huang, K., Wei, S., Liu, B., Meng, S., Long, C., 2015. Ethnobotanical study on medicinal plants used by Maonan people in China. J. Ethnobiol. Ethnomed. 11, 32.

  • Hong, X., Chen, Z., Guo, Y., Dong, Y., He, X., Chen, M., Ju, W., 2022. Combined liver, pancreas-duodenum, and kidney transplantation for patients with hepatitis B cirrhosis, uremia, and insulin-dependent diabetes. Ann. Transplant. 27, e935860.

  • Huggins, J.W., Kim, G.R., Brand, O.M., McKee, K.J., 1986. Ribavirin therapy for Hantaan virus infection in suckling mice. J. Infect. Dis. 153, 489–497.

  • Huggins, J.W., Robins, R.K., Canonico, P.G., 1984. Synergistic antiviral effects of ribavirin and the C-nucleoside analogs tiazofurin and selenazofurin against togaviruses, bunyaviruses, and arenaviruses. Antimicrob. Agents Chemother. 26, 476–480.

  • Jin, Y.H., Kwon, S., Choi, J.G., Cho, W.K., Lee, B., Ma, J.Y., 2019. Toosendanin from melia fructus suppresses influenza A virus infection by altering nuclear localization of viral polymerase PA protein. Front. Pharmacol. 10, 1025.

  • Jonsson, C.B., Figueiredo, L.T., Vapalahti, O., 2010. A global perspective on hantavirus ecology, epidemiology, and disease. Clin. Microbiol. Rev. 23, 412–441.

  • Kariwa, H., Yoshimatsu, K., Arikawa, J., 2007. Hantavirus infection in East Asia. Comp. Immunol. Microbiol. Infect. Dis. 30, 341–356.

  • Liu, X., Wang, Y., Zhang, M., Li, G., Cen, Y., 2004. Study on the inhibitory effect of cepharanthine on herpes simplex type-1 virus (HSV-1) in vitro. Zhong Yao Cai 27, 107–110 (in Chinese).

  • Llah, S.T., Mir, S., Sharif, S., Khan, S., Mir, M.A., 2018. Hantavirus induced cardiopulmonary syndrome: a public health concern. J. Med. Virol. 90, 1003–1009.

  • Matsuda, K., Hattori, S., Komizu, Y., Kariya, R., Ueoka, R., Okada, S., 2014. Cepharanthine inhibited HIV-1 cell-cell transmission and cell-free infection via modification of cell membrane fluidity. Bioorg. Med. Chem. Lett 24, 2115–2117.

  • Mercorelli, B., Palu, G., Loregian, A., 2018. Drug repurposing for viral infectious diseases:how far are we? Trends Microbiol. 26, 865–876.

  • Mertz, G.J., Miedzinski, L., Goade, D., Pavia, A.T., Hjelle, B., Hansbarger, C.O., Levy, H., Koster, F.T., Baum, K., Lindemulder, A., Wang, W., Riser, L., Fernandez, H., Whitley, R.J., 2004. Placebo-controlled, double-blind trial of intravenous ribavirin for the treatment of hantavirus cardiopulmonary syndrome in North America. Clin. Infect. Dis. 39, 1307–1313.

  • Milholland, M.T., Castro-Arellano, I., Suzan, G., Garcia-Pena, G.E., Lee, T.J., Rohde, R.E., Alonso, A.A., Mills, J.N., 2018. Global diversity and distribution of hantaviruses and their hosts. EcoHealth 15, 163–208.

  • Montoya-Ruiz, C., Diaz, F.J., Rodas, J.D., 2014. Recent evidence of hantavirus circulation in the American tropic. Viruses 6, 1274–1293.

  • Ning, T., Wang, L., Liu, S., Ma, J., Nie, J., Huang, W., Li, X., Li, Y., Wang, Y., 2021. Monitoring neutralization property change of evolving hantaan and Seoul viruses with a novel pseudovirus-based assay. Virol. Sin. 36, 104–112.

  • Pushpakom, S., Iorio, F., Eyers, P.A., Escott, K.J., Hopper, S., Wells, A., Doig, A., Guilliams, T., Latimer, J., McNamee, C., Norris, A., Sanseau, P., Cavalla, D., Pirmohamed, M., 2019. Drug repurposing: progress, challenges and recommendations. Nat. Rev. Drug Discov. 18, 41–58.

  • Sohraby, F., Bagheri, M., Aliyar, M., Aryapour, H., 2017. In silico drug repurposing of FDA-approved drugs to predict new inhibitors for drug resistant T315I mutant and wild-type BCR-ABL1: a virtual screening and molecular dynamics study. J. Mol. Graph. Model. 74, 234–240.

  • Tian, H., Stenseth, N.C., 2019. The ecological dynamics of hantavirus diseases: from environmental variability to disease prevention largely based on data from China. PLoS Neglected Trop. Dis. 13, e0006901.

  • Wang, H., Yu, Y., Jiang, Z., Cao, W.M., Wang, Z., Dou, J., Zhao, Y., Cui, Y., Zhang, H., 2016. Next-generation proteasome inhibitor MLN9708 sensitizes breast cancer cells to doxorubicin-induced apoptosis. Sci. Rep. 6, 26456.

  • Yap, D.Y.H., Li, P.H., Tang, C., So, B.Y.F., Kwan, L.P.Y., Chan, G.C.W., Lau, C.S., Chan, T.M., 2022. Long-term results of triple immunosuppression with tacrolimus added to mycophenolate and corticosteroids in the treatment of lupus nephritis. Kidney Int. Rep. 7, 516–525.

  • Ye, L., Li, J., Zhang, T., Wang, X., Wang, Y., Zhou, Y., Liu, J., Parekh, H.K., Ho, W., 2012. Mycophenolate mofetil inhibits hepatitis C virus replication in human hepatic cells. Virus Res. 168, 33–40.

  • Zhang, C.H., Wang, Y.F., Liu, X.J., Lu, J.H., Qian, C.W., Wan, Z.Y., Yan, X.G., Zheng, H.Y., Zhang, M.Y., Xiong, S., Li, J.X., Qi, S.Y., 2005. Antiviral activity of cepharanthine against severe acute respiratory syndrome coronavirus in vitro. Chin. Med. J. (Engl.) 118, 493–496.

  • Zhang, J.H., Chung, T.D., Oldenburg, K.R., 1999. A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J. Biomol. Screen 4, 67–73.

  • Zhang, L., Li, Q., Liu, Q., Huang, W., Nie, J., Wang, Y., 2017. A bioluminescent imaging mouse model for Marburg virus based on a pseudovirus system. Hum. Vaccines Immunother. 13, 1811–1817.

  • Zhang, T.T., Huang, Z.T., Dai, Y., Chen, X.P., Zhu, P., Du, G.H., 2006. High-throughput fluorescence polarization method for identifying ligands of LOX-1. Acta Pharmacol. Sin. 27, 447–452.

  • Zhou, Y.B., Wang, Y.F., Zhang, Y., Zheng, L.Y., Yang, X.A., Wang, N., Jiang, J.H., Ma, F., Yin, D.T., Sun, C.Y., Wang, Q.D., 2012. In vitro activity of cepharanthine hydrochloride against clinical wild-type and lamivudine-resistant hepatitis B virus isolates. Eur. J. Pharmacol. 683, 10–15.