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Identity (%) with strain* 1 2 3 4 5 6 7 8 9 10 11 12 1. TTMV-Zhenjiang 37.3 35.9 36.2 45.4 42.8 41.7 38.6 42 41.2 29 28.8 2. TTMV1-CBD279 27.3 41.8 43.2 41.2 35.8 44.1 39.1 39.5 38.4 28.8 29.9 3. TTMV2-NLC023 26 36.5 47.6 40 34.5 39.7 37.3 37.1 36.5 28.9 32.1 4. TTMV3-NLC026 26.9 33.7 41.4 44 36.4 40.6 38.2 38.6 38.1 28 29.8 5. TTMV4-Pt-TTV8II 38.2 30.9 33 33.9 41.1 44.7 42.7 42.7 38 28.4 30.7 6. TTMV5-TGP96 33.2 26.7 25.5 26.8 32.7 39.4 37.2 40.3 38.6 30.9 28.8 7. TTMV6-CBD203 34.6 32 32.3 32.3 37.3 27.6 47 46.8 43.4 28.5 31.4 8. TTMV7-CLC156 28 29.6 29.9 29 34.7 24.7 37.5 47.2 40.2 26.4 29.8 9. TTMV8-PB4TL 33.2 31.1 29.3 30.1 36.9 29.5 37 37.3 50.3 29.5 32.1 10. TTMV9-NLC030 32.1 29.6 28.2 27.8 34.7 28.5 36.3 34.3 43.1 29.8 28.1 11. TTV 20.7 18.1 21.5 16.3 17.1 20.7 18 17.6 20.7 20.5 29.4 12. TTMDV 18.7 23.3 23.7 18 24 22.2 22.4 18.9 22.7 18.9 22.6 Note: * The numbers represent the identities of nucleotide (above the diagonal) and amino acid (below the diagonal). Table 1. The nucleotides and amino acids identities of TTMV-Zhenjiang with published TTMVs
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Patient data Normal range Routine blood test White blood cell count (WBC) 8.21 × 109/L 4~10 × 109/L Basophil count (BASO#) 0.07 × 109/L 0~0.1 × 109/L Basophil ratio (BASO%) 0.80% 0~1% Neutrophil count (NEUT#) 6.26 × 109/L 2.0~7.5 × 109/L Neutrophil ratio (NEUT%) 76.20% 50%~70% Eosinophil count (EO#) 0.16 × 109/L 0~0.7 × 109/L Eosinophil ratio (EO%) 2.00% 0.5%~5% Lymphocyte count (LYMPH#) 1.34 × 109/L 0.8~4.0 × 109/L Lymphocyte ratio (LYMPH%) 16.30% 17%~50% Monocyte count (MONO#) 0.38 × 109/L 0.3~0.8 × 109/L Monocyte ratio (MONO%) 4.70% 3%~10% Red blood cell count (RBC) 4.07 × 1012/L 4.0~5.50 × 1012/L Hemoglobin (HGB) 125.00 g/L 120~160 g/L Mean corpuscular volume (MCV) 100.70 FL 80~100 FL Mean corpuscular hemoglobin (MCH) 30.70 pg 26~38 pg Mean corpuscular hemoglobin concentration (MCHC) 305.00 g/L 300~360 g/L Platelet (PLT) 235.00 × 109/L 100~300 × 109/L CSF analysis WBC 9 × 106/L 0~15 × 106/L Glucose 3.6 mmol/L 2.8~4.4 mmol/L Chloride 118 mmol/L 111~123 mmol/L Protein 0.40 g/L 0.15~0.45 g/L Table S1. Laboratory data for the patient with encephalitis
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Virus Abbreviation Accession no. Host Source Torque teno mini virus 1 TTMV1-CBD279 AB026931 human plasma Torque teno mini virus 2 TTMV2-NLC023 AB038629 human plasma Torque teno mini virus 3 TTMV3-NLC026 AB038630 human plasma Torque teno mini virus 4 TTMV4-Pt-TTV8-II AB041963 chimpanzees sera Torque teno mini virus 5 TTMV5-TGP96 AB041962 human sera Torque teno mini virus 6 TTMV6-CBD203 AB026929 human serum Torque teno mini virus 7 TTMV7-CLC156 AB038627 human plasma Torque teno mini virus 8 TTMV8-PB4TL AF291073 human Peripheral blood
mononuclear cellsTorque teno mini virus 9 TTMV9-NLC030 AB038631 human plasma Torque teno mini virus -LIL-y1 TTMV-LIL-y1 EF538880 human plasma Torque teno mini virus -LIL-y2 TTMV-LIL-y2 EF538881 human plasma Torque teno mini virus -LIL-y3 TTMV-LIL-y3 EF538882 human plasma TTV-like mini virus- LIL-y4 TTMV-LIL-y4 EF538883 human plasma TTV-like mini virus CLC062 TLMV-CLC062 AB038625 human Plasma TTV-like mini virus CLC138 TLMV-CLC138 AB038626 human plasma TTV-like mini virus Emory1 TTMV-Emory1 KX810063 human glioblastoma TTV-like mini virus Emory2 TTMV-Emory2 KX810064 human glioblastoma Torque teno mini virus ALA22 TTMV-ALA22 KM259873 human oral mucosa Torque teno mini virus ALH8 TTMV-ALH8 KM259874 human oral mucosa TTV-like mini virus LY2 TTMV-LY2 JX134045 human pleural effusion TTV-like mini virus LY3 TTMV-LY3 JX134046 human pleural effusion TTV-like mini virus LY1 TTMV-LY1 JX134044 human pleural effusion Table S2. The basic information of accepted TTMV members and some representative unclassified species in genus Betatorquevirus using in this study.
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