Figure 6个  Table 2个
    • Inclusion criteria Exclusion criteria
      1. Age > 18 years Active consumption of alcohol and/or drugs
      2. HBsAg-positive and HBeAg-negative for > 6 months Co-infection with human immunodeficiency virus, hepatitis C virus, or other viruses
      3. Detectable serum HBV DNA for > 3 months Clinical evidence of cirrhosis
      4. Abnormal ALT, but ≤ 10 × ULN for > 3 month History of autoimmune hepatitis
      5. No previous antiviral therapy or treatment with immunosuppressive or regulatory drugs Evidence of neoplastic diseases of the liver
      Psychiatric disease
      Severe cardiac or pulmonary disease
      HBsAg: hepatitis B surface antigen; HBeAg: hepatitis B envelop antigen; HBV: hepatitis B Virus; ALT: alanine aminotransferease; ULN: Upper limit of normal.

      Table 1.  Patient selection criteria.

    • Overall Complete response (Group 1) Partial response (Group 2) Poor response (Group 3) F/P value
      Number (%) 81(100) 12(14.81) 20(24.69) 49(60.49)
      Age (yr) 35.99 ± 9. 68 35.00 ± 8.08 30.35 ± 8.24 38.53 ± 9.56 F = 5.760 P = 0.005
      ≥40 22(27.16%) 2(16.67%) 2(10.00%) 18(36.73%)
      < 40 59(72.84%) 10(83.33%) 18(90.00%) 31(63.27%)
      Male 65(80.25%) 9(75.00%) 17 (85.00%) 39(79.60%) χ2 = 0.061 P = 0.729
      Family history of HBV 39(48.15%) 3(25.00%) 9(45.00%) 27(55.10%) χ2 = 3.604 P = 0.165
      Baseline HBsAg (log10 IU/mL) 3.24 ± 0.54 3.18 ± 0.54 3.00 ± 0.60 3.35 ± 0.49 F = 3.17 P = 0.047
      Baseline HBV DNA log10 copies/mL 5.20 ± 1.33 4.82 ± 1.35 5.19 ± 1.53 5.30 ± 1.24 F = 0.609 P = 0.546
      ≥1.0 × 4 log10 65(80.24%) 7(58.33%) 16(80.00%) 42(85.71%)
      < 1.0 × 4 log10 16(19.75%) 5(41.67%) 4(20.00%) 7(14.29%)
      Baseline ALT U/L 179.49 ± 186.98 269.35 ± 279.55 157.06 ± 146.27 167.98 ± 170.82 F= 1.492 P = 0.231
      1-2 ULN 21(25.93%) 2(16.67%) 6(30.00%) 13(26.53%)
      2-5 ULN 41(50.62%) 6(50.00%) 10(50.00%) 25(51.02%)
      > 5 ULN 19(23.46%) 4(33.33%) 4(20.00%) 11(24.45%)
      Albumin, g/L 46.74 ± 4.46 46.54 ± 3.72 46.66 ± 6.27 46.82 ± 4.46 F = 0.021 P = 0.979
      Granulocytes × 109/L 2.85 ± 1.18 3.01 ± 1.46 2.61 ± 1.26 2.89 ± 1.10 F = 0.377 P = 0.688
      Platelets × 109/L 166.74 ± 49.23 154.52 ± 59.74 148.81 ± 48.08 176.31 ± 45.45 F = 2.040 P = 0.139
      HBsAg: hepatitis B surface antigen; HBeAg: hepatitis B envelop antigen; HBV: hepatitis B virus; DNA: deoxyribonucleic acid; ALT: alanine aminotransferease; ULN: Upper limit of normal; log: logarithmic.

      Table 2.  Demographics and characteristics of patients with different HBsAg responses to treatment.