Back Article

  • Adams BD, Kasinski AL, Slack FJ, 2014: Aberrant regulation and function of microRNAs in cancer[J]. Curr Biol, 24, R762-R776. doi: 10.1016/j.cub.2014.06.043

  • Albanese M, Tagawa T, Bouvet M, Maliqi L, Lutter D, Hoser J, Hastreiter M, Hayes M, Sugden B, Martin L, Moosmann A, Hammerschmidt W, 2016: Epstein-Barr virus microRNAs reduce immune surveillance by virus-specific CD8+ T cells[J]. Proc Natl Acad Sci U S A, 113, e6467-e6475. doi: 10.1073/pnas.1605884113

  • Anastasiadou E, Boccellato F, Vincenti S, Rosato P, Bozzoni I, Frati L, Faggioni A, Presutti C, Trivedi P, 2010: Epstein-Barr virus encoded LMP1 downregulates TCL1 oncogene through miR-29b[J]. Oncogene, 29, 1316-1328. doi: 10.1038/onc.2009.439

  • Barth S, Meister G, Grasser FA, 2011: EBV-encoded miRNAs[J]. Biochim Biophys Acta, 1809, 631-640. doi: 10.1016/j.bbagrm.2011.05.010

  • Barth S, Pfuhl T, Mamiani A, Ehses C, Roemer K, Kremmer E, Jaker C, Hock J, Meister G, Grasser FA, 2008: Epstein-Barr virus-encoded microRNA miR-BART2 down-regulates the viral DNA polymerase BALF5[J]. Nucleic Acids Res, 36, 666-675.

  • Bazot Q, Paschos K, Skalska L, Kalchschmidt JS, Parker GA, Allday MJ, 2015: Epstein-Barr Virus Proteins EBNA3A and EBNA3C Together Induce Expression of the Oncogenic MicroRNA Cluster miR-221/miR-222 and Ablate Expression of Its Target p57KIP2[J]. PLoS Pathog, 11, e1005031-. doi: 10.1371/journal.ppat.1005031

  • Becker A, Thakur BK, Weiss JM, Kim HS, Peinado H, Lyden D, 2016: Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis[J]. Cancer Cell, 30, 836-848. doi: 10.1016/j.ccell.2016.10.009

  • Bellot G., Cartron PF, Er E, Oliver L, Juin P, Armstrong LC, Bornstein P, Mihara K, Manon S, Vallette FM, 2007: TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax[J]. Cell Death Differ, 14, 785-794. doi: 10.1038/sj.cdd.4402055

  • Bernhardt K, Haar J, Tsai MH, Poirey R, Feederle R, Delecluse HJ, 2016: A Viral microRNA Cluster Regulates the Expression of PTEN, p27 and of a bcl-2 Homolog[J]. PLoS Pathog, 12, e1005405-. doi: 10.1371/journal.ppat.1005405

  • Bitar A, De R, Melgar S, Aung KM, Rahman A, Qadri F, Wai SN, Shirin T, Hammarstrom ML, 2017: Induction of immunomodulatory miR-146a and miR-155 in small intestinal epithelium of Vibrio cholerae infected patients at acute stage of cholera[J]. PLoS One, 12, e0173817-. doi: 10.1371/journal.pone.0173817

  • Buchan JR, Parker R, 2007: Molecular biology[J]. The two faces of miRNA. Science, 318, 1877-1878.

  • Cai L, Ye Y, Jiang Q, Chen Y, Lyu X, Li J, Wang S, Liu T, Cai H, Yao K, Li JL, Li X, 2015: Epstein-Barr virus-encoded microRNA BART1 induces tumour metastasis by regulating PTEN-dependent pathways in nasopharyngeal carcinoma[J]. Nat Commun, 2;6, 7353-.

  • Ceccarelli S, Visco V, Raffa S, Wakisaka N, Pagano JS, Torrisi MR, 2007: Epstein-Barr virus latent membrane protein 1 promotes concentration in multivesicular bodies of fibroblast growth factor 2 and its release through exosomes[J]. Int J Cancer, 121, 1494-1506. doi: 10.1002/(ISSN)1097-0215

  • Chen X, Shi J, Zhong J, Huang Z, Luo X, Huang Y, Feng S, Shao J, Liu D, 2015: miR-1, regulated by LMP1, suppresses tumour growth and metastasis by targeting K-ras in nasopharyngeal carcinoma[J]. Int J Exp Pathol, 96, 427-432. doi: 10.1111/iep.2015.96.issue-6

  • Chen YX, Man K, Ling GS, Chen Y, Sun BS, Cheng Q, Wong OH, Lo CK, Ng IO, Chan LC, Lau GK, Lin CL, Huang F, Huang FP, 2007: A crucial role for dendritic cell (DC) IL-10 in inhibiting successful DC-based immunotherapy: superior antitumor immunity against hepatocellular carcinoma evoked by DC devoid of IL-10[J]. J Immunol, 179, 6009-6015. doi: 10.4049/jimmunol.179.9.6009

  • Cho KJ, Song J, Oh Y, Lee JE, 2015: MicroRNA-Let-7a regulates the function of microglia in inflammation[J]. Mol Cell Neurosci, 68, 167-176. doi: 10.1016/j.mcn.2015.07.004

  • Choi H, Lee H, Kim SR, Gho YS, Lee SK, 2013: Epstein-Barr virus-encoded microRNA BART15-3p promotes cell apoptosis partially by targeting BRUCE[J]. J Virol, 87, 8135-8144. doi: 10.1128/JVI.03159-12

  • Chou J, Lin JH, Brenot A, Kim JW, Provot S, Werb Z, 2013: GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression[J]. Nat Cell Biol, 15, 201-213. doi: 10.1038/ncb2672

  • Choy EY, Siu KL, Kok KH, Lung RW, Tsang CM, To KF, Kwong DL, Tsao SW, Jin DY, 2008: An Epstein-Barr virus-encoded microRNA targets PUMA to promote host cell survival[J]. J Exp Med, 205, 2551-2560. doi: 10.1084/jem.20072581

  • De Clercq E, Li G, 2016: Approved Antiviral Drugs over the Past 50 Years[J]. Clin Microbiol Rev, 29, 695-747. doi: 10.1128/CMR.00102-15

  • Diefenbach A, Jamieson AM, Liu SD, Shastri N, Raulet DH, 2000: Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages[J]. Nat Immunol, 1, 119-126. doi: 10.1038/77793

  • Ding L, Li L, Yang J, Zhou S, Li W, Tang M, Shi Y, Yi W, Cao Y, 2007: Latent membrane protein 1 encoded by Epstein-Barr virus induces telomerase activity via p16INK4A/Rb/E2F1 and JNK signaling pathways[J]. J Med Virol, 79, 1153-1163. doi: 10.1002/(ISSN)1096-9071

  • Dolken L, Malterer G, Erhard F, Kothe S, Friedel CC, Suffert G, Marcinowski L, Motsch N, Barth S, Beitzinger M, Lieber D, Bailer SM, Hoffmann R, Ruzsics Z, Kremmer E, Pfeffer S, Zimmer R, Koszinowski UH, Grasser F, Meister G, Haas J, 2010: Systematic analysis of viral and cellular microRNA targets in cells latently infected with human gamma-herpesviruses by RISC immunoprecipitation assay[J]. Cell Host Microbe, 7, 324-334. doi: 10.1016/j.chom.2010.03.008

  • Du ZM, Hu LF, Wang HY, Yan LX, Zeng YX, Shao JY, Ernberg I, 2011: Upregulation of MiR-155 in nasopharyngeal carcinoma is partly driven by LMP1 and LMP2A and downregulates a negative prognostic marker JMJD1A[J]. PLoS One, 6, e19137-. doi: 10.1371/journal.pone.0019137

  • Due H, Svendsen P, Bødker JS, Schmitz A, Bøgsted M, Johnsen HE, El-Galaly TC, Roug AS, Dybkær KF, 2016: miR-155 as a Biomarker in B-Cell Malignancies[J]. Biomed Res Int, , -. doi: 10.1155/2016/9513037

  • Dukers DF, Meij P, Vervoort MB, Vos W, Scheper RJ, Meijer CJ, Bloemena E, Middeldorp JM, 2000: Direct immunosuppressive effects of EBV-encoded latent membrane protein 1[J]. J Immunol, 165, 663-670. doi: 10.4049/jimmunol.165.2.663

  • Fabbri M, Paone A, Calore F, Galli R, Gaudio E, Santhanam R, Lovat F, Fadda P, Mao C, Nuovo GJ., Zanesi N, Crawford M, Ozer GH, Wernicke D, Alder H, Caligiuri MA, Nana-Sinkam P, Perrotti D, Croce CM, 2012: MicroRNAs bind to toll-like receptors to induce prometastatic inflammatory response[J]. Proc Natl Acad Sci USA, 109, E2110-E2116. doi: 10.1073/pnas.1209414109

  • Forte E, Salinas RE, Chang C, Zhou T, Linnstaedt SD, Gottwein E, Jacobs C, Jima D, Li QJ, Dave SS, Luftig MA, 2012: The Epstein-Barr virus (EBV)-induced tumor suppressor microRNA MiR-34a is growth promoting in EBV-infected B cells[J]. J Virol, 86, 6889-6898. doi: 10.1128/JVI.07056-11

  • Gourzones C, Gelin A, Bombik I, Klibi J, Vérillaud B, Guigay J, Lang P, Témam S, Schneider V, Amiel C, Baconnais S, Jimenez AS, Busson P, 2010: Extra-cellular release and blood diffusion of BART viral micro-RNAs produced by EBV-infected nasopharyngeal carcinoma cells[J]. Virol J, 7, 271-. doi: 10.1186/1743-422X-7-271

  • Haar J, Contrant M, Bernhardt K, Feederle R, Diederichs S, Pfeffer S, Delecluse HJ, 2016: The expression of a viral microRNA is regulated by clustering to allow optimal B cell transformation[J]. Nucleic Acids Res, 44, 1326-1341. doi: 10.1093/nar/gkv1330

  • Haneklaus M, Gerlic M, Kurowska-Stolarska M, Rainey AA, Pich D, McInnes IB, Hammerschmidt W, O’Neill LA, Masters SL, 2012: Cutting edge: miR-223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1beta production[J]. J Immunol, 189, 3795-3799. doi: 10.4049/jimmunol.1200312

  • Hooykaas MJG, van Gent M, Soppe JA, Kruse E, Boer IGJ, van Leenen D, Groot Koerkamp MJA, Holstege FCP, Ressing ME, Wiertz EJHJ, Lebbink RJ, 2017: EBV MicroRNA BART16 Suppresses Type I IFN Signaling[J]. J Immunol, 198, 4062-4073. doi: 10.4049/jimmunol.1501605

  • Huang WT, Lin CW, 2014: EBV-encoded miR-BART20-5p and miR-BART8 inhibit the IFN-gamma-STAT1 pathway associated with disease progression in nasal NK-cell lymphoma[J]. Am J Pathol, 184, 1185-1197. doi: 10.1016/j.ajpath.2013.12.024

  • Huye LE, Ning S, Kelliher M, Pagano JS, 2007: Interferon regulatory factor 7 is activated by a viral oncoprotein through RIP-dependent ubiquitination[J]. Mol Cell Biol, 27, 2910-2918. doi: 10.1128/MCB.02256-06

  • Iizasa H, Wulff BE, Alla NR, Maragkakis M, Megraw M, Hatzigeorgiou A, Iwakiri D, Takada K, Wiedmer A, Showe L, Lieberman P, Nishikura K, 2010: Editing of Epstein-Barr virus-encoded BART6 microRNAs controls their dicer targeting and consequently affects viral latency[J]. J Biol Chem, 285, 33358-33370. doi: 10.1074/jbc.M110.138362

  • Jia S, Zhai H, Zhao M, 2014: MicroRNAs regulate immune system via multiple targets[J]. Discov Med, 18, 237-247.

  • Jung YJ, Choi H, Kim H, Lee SK, 2014: MicroRNA miR-BART20-5p stabilizes Epstein-Barr virus latency by directly targeting BZLF1 and BRLF1[J]. J Virol, 88, 9027-9037. doi: 10.1128/JVI.00721-14

  • Kanda T, Miyata M, Kano M, Kondo S, Yoshizaki T, Iizasa H, 2015: Clustered microRNAs of the Epstein-Barr virus cooperatively downregulate an epithelial cell-specific metastasis suppressor[J]. J Virol, 89, 2684-2697. doi: 10.1128/JVI.03189-14

  • Kang BW, Choi Y, Kwon OK, Lee SS, Chung HY, Yu W, Bae HI, Seo AN, Kang H, Lee SK, Jeon SW, Hur K, Kim JG., 2017: High level of viral microRNA-BART20-5p expression is associated with worse survival of patients with Epstein-Barr virus-associated gastric cancer[J]. Oncotarget, 8, 14988-14994.

  • Kim DN, Lee SK, 2012: Biogenesis of Epstein-Barr virus microRNAs[J]. Mol Cell Biochem, 365, 203-210. doi: 10.1007/s11010-012-1261-7

  • Kim H, Choi H, Lee SK, 2015: Epstein-Barr virus miR-BART20-5p regulates cell proliferation and apoptosis by targeting BAD[J]. Cancer Lett, 356, 733-742. doi: 10.1016/j.canlet.2014.10.023

  • Komabayashi Y, Kishibe K, Nagato T, Ueda S, Takahara M, Harabuchi Y, 2014: Downregulation of miR-15a due to LMP1 promotes cell proliferation and predicts poor prognosis in nasal NK/T-cell lymphoma[J]. Am J Hematol, 89, 25-33. doi: 10.1002/ajh.23570

  • Li G, Wu Z, Peng Y, Liu X, Lu J, Wang L, Pan Q, He ML, Li XP, 2010a: MicroRNA-10b induced by Epstein-Barr virus-encoded latent membrane protein-1 promotes the metastasis of human nasopharyngeal carcinoma cells[J]. Cancer Lett, 299, 29-36. doi: 10.1016/j.canlet.2010.07.021

  • Li J, Fu R, Yang L, Tu W, 2015: miR-21 expression predicts prognosis in diffuse large B-cell lymphoma[J]. Int J Clin Exp Pathol, 8, 15019-15024.

  • Li L, Chen XP, Li YJ, 2010b: MicroRNA-146a and human disease[J]. Scand J Immunol, 71, 227-231. doi: 10.1111/sji.2010.71.issue-4

  • Li L, Li Z, Zhou S, Xiao L, Guo L, Tao Y, Tang M, Shi Y, Li W, Yi W, Cao Y, 2007: Ubiquitination of MDM2 modulated by Epstein-Barr virus encoded latent membrane protein 1[J]. Virus Res, 130, 275-280. doi: 10.1016/j.virusres.2007.05.013

  • Li P, Liu C, Yu Z, Wu M, 2016: New Insights into Regulatory T Cells: Exosome- and Non-Coding RNA-Mediated Regulation of Homeostasis and Resident Treg Cells[J]. Front Immunol, 7, 574-.

  • Lisnic VJ, Krmpotic A, Jonjic S, 2010: Modulation of natural killer cell activity by viruses[J]. Curr Opin Microbiol, 13, 530-539. doi: 10.1016/j.mib.2010.05.011

  • Liu X, Li L, Pan F, Tian W, 2012: MICB polymorphism in a southern Chinese Han population: the identification of two new MICB alleles, MICB*005:06 and MICB*026[J]. Hum Immunol, 73, 818-823. doi: 10.1016/j.humimm.2012.05.008

  • Liu X, Luo HN, Tian WD, Lu J, Li G1, Wang L, Zhang B, Liang BJ, Peng XH, Lin SX, Peng Y, Li XP, 2013: Diagnostic and prognostic value of plasma microRNA deregulation in nasopharyngeal carcinoma[J]. Cancer Biol Ther, 14, 1133-1142. doi: 10.4161/cbt.26170

  • Lo AK, To KF, Lo KW, Lung RW, Hui JW, Liao G, Hayward SD, 2007: Modulation of LMP1 protein expression by EBV- encoded microRNAs[J]. Proc Natl Acad Sci U S A, 104, 16164-16169. doi: 10.1073/pnas.0702896104

  • Lung RW, Tong JH, Sung YM, Leung PS, Ng DC, Chau SL, Chan AW, Ng EK, Lo KW, To KF, 2009: Modulation of LMP2A expression by a newly identified Epstein-Barr virus-encoded microRNA miR-BART22[J]. Neoplasia, 11, 1174-1184. doi: 10.1593/neo.09888

  • Luo GG, Ou JH, 2015: Oncogenic viruses and cancer[J]. Virol Sin, 30, 83-84. doi: 10.1007/s12250-015-3599-y

  • Ma J, Nie K, Redmond D, Liu Y, Elemento O, Knowles DM, Tam W, 2016: EBV-miR-BHRF1-2 targets PRDM1/Blimp1: potential role in EBV lymphomagenesis[J]. Leukemia, 30, 594-604. doi: 10.1038/leu.2015.285

  • Ma L, Deng X, Wu M, Zhang G, Huang J, 2014: Down-regulation of miRNA-204 by LMP-1 enhances CDC42 activity and facilitates invasion of EBV-associated nasopharyngeal carcinoma cells[J]. FEBS Lett, 588, 1562-1570. doi: 10.1016/j.febslet.2014.02.039

  • Mansouri S, Pan Q, Blencowe BJ, Claycomb JM, Frappier L, 2014: Epstein-Barr virus EBNA1 protein regulates viral latency through effects on let-7 microRNA and dicer[J]. J Virol, 88, 11166-11177. doi: 10.1128/JVI.01785-14

  • Marquitz AR, Mathur A, Nam CS, Raab-Traub N, 2011: The Epstein-Barr Virus BART microRNAs target the pro-apoptotic protein Bim[J]. Virology, 412, 392-400. doi: 10.1016/j.virol.2011.01.028

  • Meckes DG, Jr. , Shair KH, Marquitz AR, Kung CP, Edwards RH, Raab-Traub N, 2010: Human tumor virus utilizes exosomes for intercellular communication[J]. Proc Natl Acad Sci U S A, 107, 20370-20375. doi: 10.1073/pnas.1014194107

  • Miao BP, Zhang RS, Li M, Fu YT, Zhao M, Liu ZG, Yang PC, 2015: Nasopharyngeal cancer-derived microRNA-21 promotes immune suppressive B cells[J]. Cell Mol Immunol, 12, 750-756. doi: 10.1038/cmi.2014.129

  • Nachmani D, Stern-Ginossar N, Sarid R, Mandelboim O, 2009: Diverse herpesvirus microRNAs target the stress-induced immune ligand MICB to escape recognition by natural killer cells[J]. Cell Host Microbe, 5, 376-385. doi: 10.1016/j.chom.2009.03.003

  • Onnis A, Navari M, Antonicelli G, Morettini F, Mannucci S, De Falco G, Vigorito E, Leoncini L, 2012: Epstein-Barr nuclear antigen 1 induces expression of the cellular microRNA hsa-miR-127 and impairing B-cell differentiation in EBV-infected memory B cells[J]. New insights into the pathogenesis of Burkitt lymphoma. Blood Cancer J, 2, e84-.

  • Oussaief L, Fendri A, Chane-Woon-Ming B, Poirey R, Delecluse HJ, Joab I, Pfeffer S, 2015: Modulation of MicroRNA Cluster miR-183-96-182 Expression by Epstein-Barr Virus Latent Membrane Protein 1[J]. J Virol, 89, 12178-12188. doi: 10.1128/JVI.01757-15

  • Patel SA, Gooderham NJ, 2015: IL6 Mediates Immune and Colorectal Cancer Cell Cross-talk via miR-21 and miR-29b[J]. Mol Cancer Res, 13, 1502-1508. doi: 10.1158/1541-7786.MCR-15-0147

  • Pegtel DM, Cosmopoulos K, Thorley-Lawson DA, van Eijndhoven MA, Hopmans ES, Lindenberg JL, de Gruijl TD, Wurdinger T, Middeldorp JM, 2010: Functional delivery of viral miRNAs via exosomes[J]. Proc Natl Acad Sci U S A, 107, 6328-6333. doi: 10.1073/pnas.0914843107

  • Piedade D, Azevedo-Pereira JM, 2016: The Role of microRNAs in the Pathogenesis of Herpesvirus Infection[J]. Viruses, 8, -. doi: 10.3390/v8060156

  • Poole E, Sinclair J, 2015: Sleepless latency of human cytomegalovirus[J]. Med Microbiol Immunol, 204, 421-429. doi: 10.1007/s00430-015-0401-6

  • Qu JQ, Yi HM, Ye X, Zhu JF, Yi H, Li LN, Xiao T, Yuan L, Li JY, Wang YY, Feng J, He QY, Lu SS, Xiao ZQ, 2015: MiRNA-203 Reduces Nasopharyngeal Carcinoma Radioresistance by Targeting IL8/AKT Signaling[J]. Mol Cancer Ther, 14, 2653-2664. doi: 10.1158/1535-7163.MCT-15-0461

  • Ressing ME, van Gent M, Gram AM, Hooykaas MJ, Piersma SJ, Wiertz EJ, 2015: Immune Evasion by Epstein-Barr Virus[J]. Curr Top Microbiol Immunol, 391, 355-381.

  • Riley KJ, Rabinowitz GS, Yario TA, Luna JM, Darnell RB, Steitz JA, 2012: EBV and human microRNAs co-target oncogenic and apoptotic viral and human genes during latency[J]. EMBO J, 31, 2207-2221. doi: 10.1038/emboj.2012.63

  • Rosato P, Anastasiadou E, Garg N, Lenze D, Boccellato F, Vincenti S, Severa M, Coccia EM, Bigi R, Cirone M, Ferretti E, Campese AF, Hummel M, Frati L, Presutti C, Faggioni A, Trivedi P, 2012: Differential regulation of miR-21 and miR-146a by Epstein-Barr virus-encoded EBNA2[J]. Leukemia, 26, 2343-2352. doi: 10.1038/leu.2012.108

  • Saba R, Sorensen DL, Booth SA, 2014: MicroRNA-146a: A Dominant, Negative Regulator of the Innate Immune Response[J]. Front Immunol, 5, 578-.

  • Saki N, Abroun S, Soleimani M, Hajizamani S, Shahjahani M, Kast RE, Mortazavi Y, 2015: Involvement of MicroRNA in T-Cell Differentiation and Malignancy[J]. Int J Hematol Oncol Stem Cell Res, 9, 33-49.

  • Sheedy FJ, 2015: Turning 21: Induction of miR-21 as a Key Switch in the Inflammatory Response[J]. Front Immunol, 6, 19-.

  • Skalsky RL, Kang D, Linnstaedt SD, Cullen BR, 2014: Evolutionary conservation of primate lymphocryptovirus microRNA targets[J]. J Virol, 88, 1617-1635. doi: 10.1128/JVI.02071-13

  • Song Y, Li X, Zeng Z, Li Q, Gong Z, Liao Q, Li X, Chen P, Xiang B, Zhang W, Xiong F, Zhou Y, Zhou M, Ma J, Li Y, Chen X, Li G, Xiong W, 2016: Epstein-Barr virus encoded miR-BART11 promotes inflammation-induced carcinogenesis by targeting FOXP1[J]. Oncotarget, 7, 36783-36799.

  • Sun X, Zhang J, Hou Z, Han Q, Zhang C, Tian Z, 2015: miR-146a is directly regulated by STAT3 in human hepatocellular carcinoma cells and involved in anti-tumor immune suppression[J]. Cell Cycle, 14, 243-252. doi: 10.4161/15384101.2014.977112

  • Sun Y, Cai J, Ma F, Lu P, Huang H, Zhou J, 2012: miR-155 mediates suppressive effect of progesterone on TLR3, TLR4-triggered immune response[J]. Immunol Lett, 146, 25-30. doi: 10.1016/j.imlet.2012.04.007

  • Tagawa T AM, Bouvet M, Moosmann A, Mautner J, Heissmeyer V, Zielinski C, Lutter D, Hoser J, Hastreiter M, Hayes M, Sugden B, Hammerschmidt W, 2016: Epstein-Barr viral miRNAs inhibit antiviral CD4+ T cell responses targeting IL-12 and peptide processing[J]. J Exp Med, 213, 15-. doi: 10.1084/jem.20151570

  • Tang JF, Yu ZH, Liu T, Lin ZY, Wang YH, Yang LW, He HJ, Cao J, Huang HL, Liu G, 2014: Five miRNAs as novel diagnostic biomarker candidates for primary nasopharyngeal carcinoma[J]. Asian Pac J Cancer Prev, 15, 7575-7581. doi: 10.7314/APJCP.2014.15.18.7575

  • Tian T, Zhu YL, Zhou YY, Liang GF, Wang YY, Hu FH, Xiao ZD, 2014: Exosome uptake through clathrin-mediated endocytosis and macropinocytosis and mediating miR-21 delivery[J]. J Biol Chem, 289, 22258-22267. doi: 10.1074/jbc.M114.588046

  • Tsang CM, Tsao SW, 2015: The role of Epstein-Barr virus infection in the pathogenesis of nasopharyngeal carcinoma[J]. Virol Sin, 30, 107-121. doi: 10.1007/s12250-015-3592-5

  • Verhoeven RJ, Tong S, Zhang G, Zong J, Chen Y, Jin DY, 2016: NF-kappaB Signaling Regulates Expression of Epstein-Barr Virus BART MicroRNAs and Long Noncoding RNAs in Nasopharyngeal Carcinoma[J]. , 90, 6475-6488.

  • Wang Y, He D, Liang H, Yang D, Yue H, Zhang X, Wang R, Li B, Yang H, Liu Y, Chen Y, Duan Y, Zhang C, Chen X, Fu J, 2017: The identification of upregulated ebv-mir-BHRF1-2-5p targeting MALT1 and ebv-miR-BHRF1-3 in the circulation of patients with multiple sclerosis[J]. Clin Exp Immunol, 2017 Jul;189, 120-126.

  • Xia, O’Hara, Araujo, Barreto, Carvalho, Sapucaia, Ramos, Luz, Pedroso, Manrique, Toomey, Brites, Dittmer, Harrington, Jr, 2008: EBV microRNAs in primary lymphomas and targeting of CXCL-11 by ebv-mir-BHRF1-3[J]. Cancer Res, 68, 1436-1442. doi: 10.1158/0008-5472.CAN-07-5126

  • Yan Q, Zeng Z, Gong Z, Zhang W, Li X, He B, Song Y, Li Q, Zeng Y, Liao Q, Chen P, Shi L, Fan S, Xiang B, Ma J, Zhou M, Li X, Yang J, Xiong W, Li G, 2015: EBV-miR-BART10-3p facilitates epithelial-mesenchymal transition and promotes metastasis of nasopharyngeal carcinoma by targeting BTRC[J]. Oncotarget, 6, 41766-41782.

  • Yang F, Liu Q, Hu CM, 2015: Epstein-Barr virus-encoded LMP1 increases miR-155 expression, which promotes radioresistance of nasopharyngeal carcinoma via suppressing UBQLN1[J]. Eur Rev Med Pharmacol Sci, 19, 4507-4515.

  • Yang GD, Huang TJ, Peng LX, Yang CF, Liu RY, Huang HB, Chu QQ, Yang HJ, Huang JL, Zhu ZY, Qian CN, Huang BJ, 2013: Epstein-Barr Virus_Encoded LMP1 upregulates microRNA-21 to promote the resistance of nasopharyngeal carcinoma cells to cisplatin-induced Apoptosis by suppressing PDCD4 and Fas-L[J]. PLoS One, 8, e78355-. doi: 10.1371/journal.pone.0078355

  • Yang IV, Wade CM, Kang HM, Alper S, Rutledge H, Lackford B, Eskin E, Daly MJ, Schwartz DA, 2009: Identification of novel genes that mediate innate immunity using inbred mice[J]. Genetics, 183, 1535-1544. doi: 10.1534/genetics.109.107540

  • Yang P, Li QJ, Feng Y, Zhang Y, Markowitz GJ, Ning S, Deng Y, Zhao J, Jiang S, Yuan Y, Wang HY, Cheng SQ, Xie D, Wang XF, 2012: TGF-beta-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma[J]. Cancer Cell, 22, 291-303. doi: 10.1016/j.ccr.2012.07.023

  • Yang Y, Wu BQ, Wang YH, Shi YF, Luo JM, Ba JH, Liu H, Zhang TT, 2016: Regulatory effects of miR-155 and miR-146a on repolarization and inflammatory cytokine secretion in human alveolar macrophages in vitro[J]. Immunopharmacol Immunotoxicol, , 1-27.

  • Yang Y, Zhou H, Li W, Zhou M, Zeng Z, Xiong W, Wu M, Huang H, Zhou Y, Peng C, Huang C, Li X, Li G, 2007: Lipopolysaccharide (LPS) regulates TLR4 signal transduction in nasopharynx epithelial cell line 5-8F via NFkappaB and MAPKs signaling pathways[J]. Mol Immunol, 44, 984-992. doi: 10.1016/j.molimm.2006.03.013

  • Yin W, Ouyang S, Li Y, Xiao B, Yang H, 2013: Immature dendritic cell-derived exosomes: a promise subcellular vaccine for autoimmunity[J]. Inflammation, 36, 232-240. doi: 10.1007/s10753-012-9539-1

  • Young LS, Rickinson AB, 2004: Epstein-Barr virus: 40 years on[J]. Nat Rev Cancer, 4, 757-768. doi: 10.1038/nrc1452

  • Yu H, Lu J, Zuo L, Yan Q, Yu Z, Li X, Huang J, Zhao L, Tang H, Luo Z, Liao Q, Zeng Z, Zhang J, Li G, 2012: Epstein-Barr virus downregulates microRNA 203 through the oncoprotein latent membrane protein 1: a contribution to increased tumor incidence in epithelial cells[J]. J Virol, 86, 3088-3099. doi: 10.1128/JVI.05901-11

  • Yu P, Xiao L, Lin L, Tang L, Chen C, Wang F, Wang Y, 2016: STAT3-mediated TLR2/4 pathway upregulation in an IFN-gamma-induced Chlamydia trachomatis persistent infection model[J]. Pathog Dis, 74, -. doi: 10.1093/femspd/ftw076

  • Yu Z, Lu J, Yu H, Yan Q, Zuo L, Li G, 2011: A precise excision of the complete Epstein-Barr virus genome in a plasmid based on a bacterial artificial chromosome[J]. J Virol Methods, 176, 103-107. doi: 10.1016/j.jviromet.2011.06.015

  • Zeng FR, Tang LJ, He Y, Garcia RC, 2015: An update on the role of miRNA-155 in pathogenic microbial infections[J]. Microbes Infect, 17, 613-621. doi: 10.1016/j.micinf.2015.05.007

  • Zeng L, Cui J, Wu H, Lu Q, 2014: The emerging role of circulating microRNAs as biomarkers in autoimmune diseases[J]. Autoimmunity, 47, 419-429. doi: 10.3109/08916934.2014.929667

  • Zhang G, Zong J, Lin S, Verhoeven RJ, Tong S, Chen Y, Ji M, Cheng W, Tsao SW, Lung M, Pan J, Chen H, 2015: Circulating Epstein-Barr virus microRNAs miR-BART7 and miR-BART13 as biomarkers for nasopharyngeal carcinoma diagnosis and treatment[J]. Int J Cancer, Mar 1;136, E301-E312.

  • Zhang J, Jia G, Liu Q, Hu J, Yan M, Yang B, Yang H, Zhou W, Li J, 2015a: Silencing miR-146a influences B cells and ameliorates experimental autoimmune myasthenia gravis[J]. Immunology, 144, 56-67. doi: 10.1111/imm.2014.144.issue-1

  • Zhang J, Li S, Li L, Li M, Guo C, Yao J, Mi S, 2015b: Exosome and exosomal microRNA: trafficking, sorting, and function[J]. Genomics Proteomics Bioinformatics, 13, 17-24. doi: 10.1016/j.gpb.2015.02.001

  • Zhao Y, Chen X, Jing M, Du H, Zeng Y, 2012: Expression of miRNA-146a in nasopharyngeal carcinoma is upregulated by Epstein-Barr virus latent membrane protein 1[J]. Oncol Rep, 28, 1237-1242.

  • Zheng H, Li LL, Hu DS, Deng XY, Cao Y, 2007: Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma[J]. Cell Mol Immunol, 4, 185-196.

  • Zheng XH, Lu LX, Cui C, Chen MY, Li XZ, Jia WH, 2016: Epstein-Barr virus mir-bart1-5p detection via nasopharyngeal brush sampling is effective for diagnosing nasopharyngeal carcinoma[J]. Oncotarget, 7, 4972-4980.

  • Zhu H, Luo H, Li Y, Zhou Y, Jiang Y, Chai J, Xiao X, You Y, Zuo X, 2013: MicroRNA-21 in scleroderma fibrosis and its function in TGF-beta-regulated fibrosis-related genes expression[J]. J Clin Immunol, 33, 1100-1109. doi: 10.1007/s10875-013-9896-z