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  • Abraham R T, Weiss A. Jurkat T cells and development of the T-cell receptor signalling paradigm[J]. Nat Rev Immunol, 2004, 4(): 301-308. doi: 10.1038/nri1330

  • Alegre M L, Frauwirth K A, Thompson C B. T-cell regulation by CD28 and CTLA-4[J]. Nat Rev Immunol, 2001, 1(): 220-228. doi: 10.1038/35105024

  • Aubert M, Blaho J A. Modulation of apoptosis during herpes simplex virus infection in human cells[J]. Microbes Infect, 2001, 3(): 859-866. doi: 10.1016/S1286-4579(01)01444-7

  • Barcy S, Corey L. Herpes simplex inhibits the capacity of lymphoblastoid B cell lines to stimulate CD4+ T cells[J]. J Immunol, 2001, 166(): 6242-6249. doi: 10.4049/jimmunol.166.10.6242

  • Benetti L, Roizman B. Herpes simplex virus protein kinase US3 activates and functionally overlaps protein kinase A to block apoptosis[J]. Proc Natl Acad Sci USA, 2004, 101(): 9411-9416. doi: 10.1073/pnas.0403160101

  • Braun R W, Teute H K, Kirchner H. Replication of herpes simplex virus in human T lymphocytes: characterization of the viral target cell[J]. J Immunol, 1984, 132(): 914-919.

  • Carfi A, Willis S H, Whitbeck J C. Herpes simplex virus glycoprotein D bound to the human receptor HveA[J]. Mol Cell, 2001, 8(): 169-179. doi: 10.1016/S1097-2765(01)00298-2

  • Celum C L. The interaction between herpes simplex virus and human immunodeficiency virus[J]. Herpes, 2004, Suppl 1(): 36A-45A.

  • Chan A C, Dalton M, Johnson R. Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function[J]. EMBO J, 1995, 14(): 2499-2508.

  • Cheshenko N, Liu W, Satlin L M. Multiple receptor interactions trigger release of membrane and intracellular calcium stores critical for herpes simplex virus entry[J]. Mol Biol Cell, 2007, 18(): 3119-3130. doi: 10.1091/mbc.E07-01-0062

  • Chuang E, Fisher T S, Morgan R W. The CD28 and CTLA-4 receptors associate with the serine/ threonine phosphatase PP2A[J]. Immunity, 2000, 13(): 313-322. doi: 10.1016/S1074-7613(00)00031-5

  • Cheung T C, Humphreys I R, Potter K G. Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway[J]. Proc Natl Acad Sci USA, 2005, 102(): 13218-3223. doi: 10.1073/pnas.0506172102

  • Compaan D M, Gonzalez L C, Tom I. Attenuating lymphocyte activity: the crystal structure of the BTLA-HVEM complex[J]. J Biol Chem, 2005, 280(): 39553-39561. doi: 10.1074/jbc.M507629200

  • Corey L, Wald A, Celum C L. The effects of herpes simplex virus-2 on HIV-1 acquisition and trans-mission: a review of two overlapping epidemics[J]. J Acquir Immune Defic Syndr, 2004, 35(5): 435-445. doi: 10.1097/00126334-200404150-00001

  • Coudronniere N, Villalba M, Englund N. NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta[J]. Proc Natl Acad Sci USA, 2000, 97(): 3394-3399.

  • Cowan FM, Humphrey J H, Ntozini R. Maternal Herpes simplex virus type 2 infection, syphilis and risk of intra-partum transmission of HIV-1: results of a case control study[J]. AIDS, 2008, 22(2): 193-201. doi: 10.1097/QAD.0b013e3282f2a939

  • Derijard B, Hibi M, Wu I H. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain[J]. Cell, 1994, 76(): 1025-1037. doi: 10.1016/0092-8674(94)90380-8

  • Fruh K, Ahn K, Djaballah H. A viral inhibitor of peptide transporters for antigen presentation[J]. Nature, 1995, 375(): 415-418. doi: 10.1038/375415a0

  • Gavrieli M, Watanabe N, Loftin S K. Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of B and T lymphocyte attenuator required for association with protein tyrosine phosphatases SHP-1 and SHP-2[J]. Biochem Biophys Res Commun, 2003, 312(): 1236-1243. doi: 10.1016/j.bbrc.2003.11.070

  • Golembewski E K, Wales S Q, Aurelian L. The HSV-2 protein ICP10PK prevents neuronal apoptosis and loss of function in an in vivo model of neurode-generation associated with glutamate excitotoxicity[J]. Exp Neurol, 2007, 203(): 381-393. doi: 10.1016/j.expneurol.2006.08.022

  • Gonzalez L C, Loyet K M, Calemine-Fenaux J. A coreceptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator[J]. Proc Natl Acad Sci USA, 2005, 102(): 1116-1121. doi: 10.1073/pnas.0409071102

  • Goodkin M L, Morton E R, Blaho J A. Herpes simplex virus infection and apoptosis[J]. Int Rev Immunol, 2004, 23(): 141-172. doi: 10.1080/08830180490265574

  • Gupta A, Gartner J J, Sethupathy P. Anti-apoptotic function of a microRNA encoded by the HSV-1 latency-associated transcript[J]. Nature, 2006, 442(): 82-85.

  • Hammer S M, Carney W P, Iacoviello V R. Herpes simplex virus infection of human T-cell subpopu-lations[J]. Infect Immun, 1982, 38(): 795-797.

  • Han J Y, Sloan D D, Aubert M. Apoptosis and antigen receptor function in T and B cells following exposure to herpes simplex virus[J]. Virology, 2007, 359(): 253-263. doi: 10.1016/j.virol.2006.09.038

  • Hargett D, McLean T, Bachenheimer S L. Herpes simplex virus ICP27 activation of stress kinases JNK and p38[J]. J Virol, 2005, 79(): 8348-8360. doi: 10.1128/JVI.79.13.8348-8360.2005

  • Houtman J C, Houghtling R A, Barda-Saad M. Early phosphorylation kinetics of proteins involved in proximal TCR-mediated signaling pathways[J]. J Immunol, 2005, 175(): 2449-2458. doi: 10.4049/jimmunol.175.4.2449

  • Hsu H, Solovyev I, Colombero A. ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5[J]. J Biol Chem, 1997, 272(): 13471-13474. doi: 10.1074/jbc.272.21.13471

  • Hughes K, Edin S, Antonsson A. Calmodulin-dependent kinase Ⅱ mediates T cell receptor/ CD3-and phorbol ester-induced activation of IkappaB kinase[J]. J Biol Chem, 2001, 276(): 36008-36013. doi: 10.1074/jbc.M106125200

  • Hurchla M A, Sedy J R, Gavrieli M. B and T lymphocyte attenuator exhibits structural and expression polymorphisms and is highly Induced in anergic CD4+ T cells[J]. J Immunol, 2005, 174(): 3377-3385. doi: 10.4049/jimmunol.174.6.3377

  • Hutloff A, Dittrich A M, Beier K C. ICOS is an inducible T-cell co-stimulator structurally and func-tionally related to CD28[J]. Nature, 1999, 397(): 263-266. doi: 10.1038/16717

  • Ito M, Watanabe M, Kamiya H. Herpes simplex virus type 1 induces apoptosis in peripheral blood T lymphocytes[J]. J Infect Dis, 1997, 175(): 1220-. doi: 10.1086/jid.1997.175.issue-5

  • Iwahori S, Shirata N, Kawaguchi Y. Enhanced phosphorylation of transcription factor sp1 in response to herpes simplex virus type 1 infection is dependent on the ataxia telangiectasia-mutated protein[J]. J Virol, 2007, 81(): 9653-9664. doi: 10.1128/JVI.00568-07

  • Kim D B, DeLuca N A. Phosphorylation of Transcription Factor Sp1 during Herpes Simplex Virus Type 1 Infection[J]. J Virol, 2002, 76(): 6473-6479. doi: 10.1128/JVI.76.13.6473-6479.2002

  • Kwon B S, Tan K B, Ni J. A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation[J]. J Biol Chem, 1997, 272(): 14272-14276. doi: 10.1074/jbc.272.22.14272

  • La S, Kim J, Kwon B S. Herpes simplex virus type 1 glycoprotein D inhibits T-cell proliferation[J]. Mol Cells, 2002, 14(): 398-403.

  • Lilley C E, Carson C T, Muotri A R. DNA repair proteins affect the lifecycle of herpes simplex virus 1[J]. Proc Natl Acad Sci USA, 2005, 102(): 5844-5849. doi: 10.1073/pnas.0501916102

  • Lin J, Weiss A. T cell receptor signaling[J]. J Cell Sci, 2001, 114(): 243-244.

  • Marsters S A, Ayres T M, Skubatch M. Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1[J]. J Biol Chem, 1997, 272(): 14029-14032. doi: 10.1074/jbc.272.22.14029

  • Mauri D N, Ebner R, Montgomery R I. LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator[J]. Immunity, 1998, 8(): 21-30. doi: 10.1016/S1074-7613(00)80455-0

  • Montgomery R I, Warner M S, Lum B J. Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family[J]. Cell, 1996, 87(): 427-436. doi: 10.1016/S0092-8674(00)81363-X

  • Mulvey M, Arias C, Mohr I. Maintenance of endoplasmic reticulum (ER) homeostasis in herpes simplex virus type 1-infected cells through the association of a viral glycoprotein with PERK, a cellular ER stress sensor[J]. J Virol, 2007, 81(): 3377-3390. doi: 10.1128/JVI.02191-06

  • Murphy K M, Nelson C A, Sedy J R. Balancing co-stimulation and inhibition with BTLA and HVEM[J]. Nat Rev Immunol, 2006, 6(): 671-681. doi: 10.1038/nri1917

  • Mustelin T, Tasken K. Positive and negative regulation of T-cell activation through kinases and phosp-hatases[J]. Biochem J, 2003, 371(): 15-27. doi: 10.1042/bj20021637

  • Nel A E. -cell activation through the antigen receptor. Part 1: signaling components, signaling pathways, and signal integration at the T-cell antigen receptor synapse[J]. J Allergy Clin Immunol, 2002, 109(): 758-770. doi: 10.1067/mai.2002.124259

  • Neumann J, Eis-Hubinger A M, Koch N. Herpes simplex virus type 1 targets the MHC class Ⅱ processing pathway for immune evasion[J]. J Immunol, 2003, 171(): 3075-3083. doi: 10.4049/jimmunol.171.6.3075

  • Okazaki T, Maeda A, Nishimura H. PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine[J]. Proc Natl Acad Sci USA, 2001, 98(): 13866-13871. doi: 10.1073/pnas.231486598

  • Okkenhaug K, Bilancio A, Emery J L. Phosphoinositide 3-kinase in T cell activation and survival[J]. Biochem Soc Trans, 2004, 32(): 332-335. doi: 10.1042/bst0320332

  • Parry R V, Chemnitz J M, Frauwirth K A. CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms[J]. Mol Cell Biol, 2005, 25(): 9543-9553. doi: 10.1128/MCB.25.21.9543-9553.2005

  • Pasieka T J, Baas T, Carter V S. Functional genomic analysis of herpes simplex virus type 1 coun-teraction of the host innate response[J]. J Virol, 2006, 80(): 7600-7612. doi: 10.1128/JVI.00333-06

  • Prasad K V, Cai Y C, Raab M. T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif[J]. Proc Natl Acad Sci USA, 1994, 91(): 2834-2838. doi: 10.1073/pnas.91.7.2834

  • Raab M, Pfister S, Rudd C E. CD28 signaling via VAV/SLP-76 adaptors: regulation of cytokine transcription independent of TCR ligation[J]. Immunity, 2001, 15(): 921-933. doi: 10.1016/S1074-7613(01)00248-5

  • Raftery M J, Behrens C K, Muller A. Herpes simplex virus type 1 infection of activated cytotoxic T cells: Induction of fratricide as a mechanism of viral immune evasion[J]. J Exp Med, 1999, 190(): 1103-1114. doi: 10.1084/jem.190.8.1103

  • Roizman B, Knipe D M, Whitley R J. 2007. Herpes Simplex Viruses. In: Fields Virology (Knipe D M, Howley P M, eds. ), 5th ed. Lippincott Williams & Wilkins, p2502-2602.

  • Salvador J M, Mittelstadt P R, Guszczynski T. Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases[J]. Nat Immunol, 2005, 6(): 390-395. doi: 10.1038/ni1177

  • Sedy J R, Gavrieli M, Potter K G. B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator[J]. Nat Immunol, 2005, 6(): 90-98. doi: 10.1038/ni1144

  • Sievers E, Neumann J, Raftery M. Glycoprotein B from strain 17 of herpes simplex virus type I contains an invariant chain homologous sequence that binds to MHC class Ⅱ molecules[J]. Immunology, 2002, 107(): 129-135. doi: 10.1046/j.1365-2567.2002.01472.x

  • Sloan D D, Han J Y, Sandifer T K. Inhibition of TCR signaling by herpes simplex virus[J]. J Immunol, 2006, 176(): 1825-1833. doi: 10.4049/jimmunol.176.3.1825

  • Sloan D D, Jerome K R. Herpes simplex virus remodels T-cell receptor signaling, resulting in p38-dependent selective synthesis of interleukin-10[J]. J Virol, 2007, 81(): 12504-12514. doi: 10.1128/JVI.01111-07

  • Sloan D D, Zahariadis G, Posavad C M. CTL are inactivated by herpes simplex virus-infected cells expressing a viral protein kinase[J]. J Immunol, 2003, 171(): 6733-6741. doi: 10.4049/jimmunol.171.12.6733

  • Sommers C L, Menon R K, Grinberg A. Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development[J]. J Exp Med, 2001, 194(): 135-142. doi: 10.1084/jem.194.2.135

  • Sprecher E, Becker Y. Langerhans cell density and activity in mouse skin and lymph nodes affect herpes simplex type 1 (HSV-1) pathogenicity[J]. Arch Virol, 1989, 107(): 191-205. doi: 10.1007/BF01317916

  • Verjans G M, Hintzen R Q, van Dun J M. Selective retention of herpes simplex virus-specific T cells in latently infected human trigeminal ganglia[J]. Proc Natl Acad Sci USA, 2007, 104(): 3496-3501. doi: 10.1073/pnas.0610847104

  • Wange R L. LAT, the linker for activation of T cells: a bridge between T cell-specific and general signaling pathways[J]. Sci STKE, 2000, 2000(): RE1-.

  • Watanabe N, Gavrieli M, Sedy J R. BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1[J]. Nat Immunol, 2003, 4(): 670-679.

  • York I A, Roop C, Andrews D W. A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes[J]. Cell, 1994, 77(): 525-535. doi: 10.1016/0092-8674(94)90215-1

  • Zachos G, Clements B, Conner J. Herpes simplex virus type 1 infection stimulates p38/c-Jun N-terminal mitogen-activated protein kinase pathways and activates transcription factor AP-1[J]. J Biol Chem, 1999, 274(): 5097-5103. doi: 10.1074/jbc.274.8.5097

  • Zhang J, Salojin K V, Gao J X. p38 mitogen-activated protein kinase mediates signal inte-gration of TCR/CD28 costimulation in primary murine T cells[J]. J Immunol, 1999, 162(): 3819-3829.

  • Zhang W, Sloan-Lancaster J, Kitchen J. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation[J]. Cell, 1998, 92(): 83-92. doi: 10.1016/S0092-8674(00)80901-0

  • Zhao X, Deak E, Soderberg K. Vaginal Submucosal Dendritic Cells, but Not Langerhans Cells, Induce Protective Th1 Responses to Herpes Simplex Virus-2[J]. J Exp Med, 2003, 197(): 153-162. doi: 10.1084/jem.20021109

  • Zhu M, Janssen E, Zhang W. Minimal requirement of tyrosine residues of linker for activation of T cells in TCR signaling and thymocyte development[J]. J Immunol, 2003, 170(): 325-333. doi: 10.4049/jimmunol.170.1.325