• Bedient, L., Pokharel, S.M., Chiok, K.R., Mohanty, I., Beach, S.S., Miura, T.A., Bose, S., 2020. Lytic Cell Death Mechanisms in Human Respiratory Syncytial Virus-Infected Macrophages:Roles of Pyroptosis and Necroptosis. Viruses 12.

  • Bian, P., Ye, C., Zheng, X., Luo, C., Yang, J., Li, M., Wang, Y., Yang, J., Zhou, Y., Zhang, F., Lian, J., Zhang, Y., Jia, Z., Lei, Y., 2020. RIPK3 Promotes JEV Replication in Neurons via Downregulation of IFI44L. Frontiers in microbiology 11, 368.

  • Christgen, S., Tweedell, R.E., Kanneganti, T.D., 2022. Programming inflammatory cell death for therapy. Pharmacology & therapeutics 232, 108010.

  • Daffis, S., Szretter, K.J., Schriewer, J., Li, J., Youn, S., Errett, J., Lin, T.Y., Schneller, S., Zust, R., Dong, H., Thiel, V., Sen, G.C., Fensterl, V., Klimstra, W.B., Pierson, T.C., Buller, R.M., Gale, M., Jr., Shi, P.Y., Diamond, M.S., 2010. 2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members. Nature 468, 452-456.

  • Dai, J., Pan, W., Wang, P., 2011. ISG15 facilitates cellular antiviral response to dengue and west nile virus infection in vitro. Virology journal 8, 468.

  • Dermentzaki, G., Politi, K.A., Lu, L., Mishra, V., Pérez-Torres, E.J., Sosunov, A.A., McKhann, G.M., 2nd, Lotti, F., Shneider, N.A., Przedborski, S., 2019. Deletion of Ripk3 Prevents Motor Neuron Death In Vitro but not In Vivo. eNeuro 6.

  • Downey, J., Pernet, E., Coulombe, F., Allard, B., Meunier, I., Jaworska, J., Qureshi, S., Vinh, D.C., Martin, J.G., Joubert, P., Divangahi, M., 2017. RIPK3 interacts with MAVS to regulate type I IFN-mediated immunity to Influenza A virus infection. PLoS pathogens 13, e1006326.

  • Ermonval, M., Baychelier, F., Tordo, N., 2016. What Do We Know about How Hantaviruses Interact with Their Different Hosts? Viruses 8.

  • Fuchs, J., Hölzer, M., Schilling, M., Patzina, C., Schoen, A., Hoenen, T., Zimmer, G., Marz, M., Weber, F., Müller, M.A., Kochs, G., 2017. Evolution and Antiviral Specificities of Interferon-Induced Mx Proteins of Bats against Ebola, Influenza, and Other RNA Viruses. Journal of virology 91.

  • Gaba, A., Xu, F., Lu, Y., Park, H.S., Liu, G., Zhou, Y., 2019. The NS1 Protein of Influenza A Virus Participates in Necroptosis by Interacting with MLKL and Increasing Its Oligomerization and Membrane Translocation. Journal of virology 93.

  • Giannakopoulos, N.V., Arutyunova, E., Lai, C., Lenschow, D.J., Haas, A.L., Virgin, H.W., 2009. ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virus. Journal of virology 83, 1602-1610.

  • Golden, J.W., Hammerbeck, C.D., Mucker, E.M., Brocato, R.L., 2015. Animal Models for the Study of Rodent-Borne Hemorrhagic Fever Viruses:Arenaviruses and Hantaviruses. BioMed research international 2015, 793257.

  • Gordon, S., Martinez, F.O., 2010. Alternative activation of macrophages:mechanism and functions. Immunity 32, 593-604.

  • Gowen, B.B., Hickerson, B.T., 2017. Hemorrhagic fever of bunyavirus etiology:disease models and progress towards new therapies. Journal of microbiology (Seoul, Korea) 55, 183-195.

  • Haller, O., Kochs, G., Weber, F., 2007. Interferon, Mx, and viral countermeasures. Cytokine & growth factor reviews 18, 425-433.

  • Handke, W., Oelschlegel, R., Franke, R., Krüger, D.H., Rang, A., 2009. Hantaan virus triggers TLR3-dependent innate immune responses. Journal of immunology (Baltimore, Md.:1950) 182, 2849-2858.

  • Hansen, L.W., Jacob, A., Yang, W.L., Bolognese, A.C., Prince, J., Nicastro, J.M., Coppa, G.F., Wang, P., 2018. Deficiency of receptor-interacting protein kinase 3 (RIPK3) attenuates inflammation and organ injury in neonatal sepsis. Journal of pediatric surgery 53, 1699-1705.

  • Hardestam, J., Klingström, J., Mattsson, K., Lundkvist, A., 2005. HFRS causing hantaviruses do not induce apoptosis in confluent Vero E6 and A-549 cells. Journal of medical virology 76, 234-240.

  • Heap, R.E., Marín-Rubio, J.L., Peltier, J., Heunis, T., Dannoura, A., Moore, A., Trost, M., 2021. Proteomics characterisation of the L929 cell supernatant and its role in BMDM differentiation. Life science alliance 4.

  • Hsiang, T.Y., Zhao, C., Krug, R.M., 2009. Interferon-induced ISG15 conjugation inhibits influenza A virus gene expression and replication in human cells. Journal of virology 83, 5971-5977.

  • Hsiao, N.W., Chen, J.W., Yang, T.C., Orloff, G.M., Wu, Y.Y., Lai, C.H., Lan, Y.C., Lin, C.W., 2010. ISG15 over-expression inhibits replication of the Japanese encephalitis virus in human medulloblastoma cells. Antiviral research 85, 504-511.

  • Hussain, M., Zimmermann, V., van Wijk, S.J.L., Fulda, S., 2018. Mouse lung fibroblasts are highly susceptible to necroptosis in a reactive oxygen species-dependent manner. Biochemical pharmacology 153, 242-247.

  • Jiang, H., Du, H., Wang, L.M., Wang, P.Z., Bai, X.F., 2016. Hemorrhagic Fever with Renal Syndrome:Pathogenesis and Clinical Picture. Frontiers in cellular and infection microbiology 6, 1.

  • Kaiser, W.J., Sridharan, H., Huang, C., Mandal, P., Upton, J.W., Gough, P.J., Sehon, C.A., Marquis, R.W., Bertin, J., Mocarski, E.S., 2013. Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL. The Journal of biological chemistry 288, 31268-31279.

  • Kariwa, H., Yoshimatsu, K., Arikawa, J., 2007. Hantavirus infection in East Asia. Comp Immunol Microbiol Infect Dis 30, 341-356.

  • Karlberg, H., Tan, Y.J., Mirazimi, A., 2011. Induction of caspase activation and cleavage of the viral nucleocapsid protein in different cell types during Crimean-Congo hemorrhagic fever virus infection. The Journal of biological chemistry 286, 3227-3234.

  • Kimura, T., Katoh, H., Kayama, H., Saiga, H., Okuyama, M., Okamoto, T., Umemoto, E., Matsuura, Y., Yamamoto, M., Takeda, K., 2013. Ifit1 inhibits Japanese encephalitis virus replication through binding to 5' capped 2'-O unmethylated RNA. Journal of virology 87, 9997-10003.

  • Koehler, H., Cotsmire, S., Zhang, T., Balachandran, S., Upton, J.W., Langland, J., Kalman, D., Jacobs, B.L., Mocarski, E.S., 2021. Vaccinia virus E3 prevents sensing of Z-RNA to block ZBP1-dependent necroptosis. Cell host & microbe 29, 1266-1276.e1265.

  • Laskowski, R.A., 2001. PDBsum:summaries and analyses of PDB structures. Nucleic acids research 29, 221-222.

  • Lee, A.J., Ashkar, A.A., 2018. The Dual Nature of Type I and Type II Interferons. Frontiers in immunology 9, 2061.

  • Li, B., Wang, X., Yu, M., Yang, P., Wang, W., 2020. G6PD, bond by miR-24, regulates mitochondrial dysfunction and oxidative stress in phenylephrine-induced hypertrophic cardiomyocytes. Life sciences 260, 118378.

  • Lu, D.H., Jiang, H., Lian, J.Q., 2021. Hantavirus Infection during Pregnancy. Virologica Sinica 36, 345-353.

  • Ma, H., Han, P., Ye, W., Chen, H., Zheng, X., Cheng, L., Zhang, L., Yu, L., Wu, X., Xu, Z., Lei, Y., Zhang, F., 2017a. The Long Noncoding RNA NEAT1 Exerts Antihantaviral Effects by Acting as Positive Feedback for RIG-I Signaling. Journal of virology 91.

  • Ma, H.W., Ye, W., Chen, H.S., Nie, T.J., Cheng, L.F., Zhang, L., Han, P.J., Wu, X.A., Xu, Z.K., Lei, Y.F., Zhang, F.L., 2017b. In-Cell Western Assays to Evaluate Hantaan Virus Replication as a Novel Approach to Screen Antiviral Molecules and Detect Neutralizing Antibody Titers. Frontiers in cellular and infection microbiology 7, 269.

  • Ma, R., Zhang, X., Shu, J., Liu, Z., Sun, W., Hou, S., Lv, Y., Ying, Q., Wang, F., Jin, X., Liu, R., Wu, X., 2021. Nlrc3 Knockout Mice Showed Renal Pathological Changes After HTNV Infection. Frontiers in immunology 12, 692509.

  • Malakhova, O.A., Zhang, D.E., 2008. ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response. The Journal of biological chemistry 283, 8783-8787.

  • Martens, S., Bridelance, J., Roelandt, R., Vandenabeele, P., Takahashi, N., 2021. MLKL in cancer:more than a necroptosis regulator. Cell death and differentiation 28, 1757-1772.

  • Meng, Y., Sandow, J.J., Czabotar, P.E., Murphy, J.M., 2021. The regulation of necroptosis by post-translational modifications. Cell death and differentiation 28, 861-883.

  • Mesev, E.V., LeDesma, R.A., Ploss, A., 2019. Decoding type I and III interferon signalling during viral infection. Nature microbiology 4, 914-924.

  • Newton, K., Dugger, D.L., Wickliffe, K.E., Kapoor, N., de Almagro, M.C., Vucic, D., Komuves, L., Ferrando, R.E., French, D.M., Webster, J., Roose-Girma, M., Warming, S., Dixit, V.M., 2014. Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis. Science (New York, N.Y.) 343, 1357-1360.

  • Nguyen, L.N., Kanneganti, T.D., 2022. PANoptosis in Viral Infection:The Missing Puzzle Piece in the Cell Death Field. Journal of molecular biology 434, 167249.

  • Ning, T., Wang, L., Liu, S., Ma, J., Nie, J., Huang, W., Li, X., Li, Y., Wang, Y., 2021. Monitoring Neutralization Property Change of Evolving Hantaan and Seoul Viruses with a Novel Pseudovirus-Based Assay. Virologica Sinica 36, 104-112.

  • Orinska, Z., Bulanova, E., Budagian, V., Metz, M., Maurer, M., Bulfone-Paus, S., 2005. TLR3-induced activation of mast cells modulates CD8+ T-cell recruitment. Blood 106, 978-987.

  • Park, K., Kim, W.K., Lee, S.H., Kim, J., Lee, J., Cho, S., Lee, G.Y., No, J.S., Lee, K.H., Song, J.W., 2021. A novel genotype of Hantaan orthohantavirus harbored by Apodemus agrarius chejuensis as a potential etiologic agent of hemorrhagic fever with renal syndrome in Republic of Korea. PLoS neglected tropical diseases 15, e0009400.

  • Pasparakis, M., Vandenabeele, P., 2015. Necroptosis and its role in inflammation. Nature 517, 311-320.

  • Perng, Y.C., Lenschow, D.J., 2018. ISG15 in antiviral immunity and beyond. Nat Rev Microbiol 16, 423-439.

  • Pinto, A.K., Williams, G.D., Szretter, K.J., White, J.P., Proença-Módena, J.L., Liu, G., Olejnik, J., Brien, J.D., Ebihara, H., Mühlberger, E., Amarasinghe, G., Diamond, M.S., Boon, A.C., 2015. Human and Murine IFIT1 Proteins Do Not Restrict Infection of Negative-Sense RNA Viruses of the Orthomyxoviridae, Bunyaviridae, and Filoviridae Families. Journal of virology 89, 9465-9476.

  • Raftery, M.J., Abdelaziz, M.O., Hofmann, J., Schönrich, G., 2018. Hantavirus-Driven PD-L1/PD-L2 Upregulation:An Imperfect Viral Immune Evasion Mechanism. Frontiers in immunology 9, 2560.

  • Raftery, M.J., Lalwani, P., Lütteke, N., Kobak, L., Giese, T., Ulrich, R.G., Radosa, L., Krüger, D.H., Schönrich, G., 2020. Replication in the Mononuclear Phagocyte System (MPS) as a Determinant of Hantavirus Pathogenicity. Frontiers in cellular and infection microbiology 10, 281.

  • Reynaud, J.M., Kim, D.Y., Atasheva, S., Rasalouskaya, A., White, J.P., Diamond, M.S., Weaver, S.C., Frolova, E.I., Frolov, I., 2015. IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I Interferon. PLoS pathogens 11, e1004863.

  • Saleh, D., Najjar, M., Zelic, M., Shah, S., Nogusa, S., Polykratis, A., Paczosa, M.K., Gough, P.J., Bertin, J., Whalen, M., Fitzgerald, K.A., Slavov, N., Pasparakis, M., Balachandran, S., Kelliher, M., Mecsas, J., Degterev, A., 2017. Kinase Activities of RIPK1 and RIPK3 Can Direct IFN-β Synthesis Induced by Lipopolysaccharide. Journal of immunology (Baltimore, Md.:1950) 198, 4435-4447.

  • Salentin, S., Schreiber, S., Haupt, V.J., Adasme, M.F., Schroeder, M., 2015. PLIP:fully automated protein-ligand interaction profiler. Nucleic acids research 43, W443-447.

  • Schneider, W.M., Chevillotte, M.D., Rice, C.M., 2014. Interferon-stimulated genes:a complex web of host defenses. Annu Rev Immunol 32, 513-545.

  • Schnittler, H.J., Feldmann, H., 2003. Viral hemorrhagic fever——a vascular disease? Thromb Haemost 89, 967-972.

  • Scholz, S., Baharom, F., Rankin, G., Maleki, K.T., Gupta, S., Vangeti, S., Pourazar, J., Discacciati, A., Höijer, J., Bottai, M., Björkström, N.K., Rasmuson, J., Evander, M., Blomberg, A., Ljunggren, H.G., Klingström, J., Ahlm, C., Smed-Sörensen, A., 2017. Human hantavirus infection elicits pronounced redistribution of mononuclear phagocytes in peripheral blood and airways. PLoS pathogens 13, e1006462.

  • Shrum, B., Anantha, R.V., Xu, S.X., Donnelly, M., Haeryfar, S.M., McCormick, J.K., Mele, T., 2014. A robust scoring system to evaluate sepsis severity in an animal model. BMC research notes 7, 233.

  • Solà-Riera, C., García, M., Ljunggren, H.G., Klingström, J., 2020. Hantavirus inhibits apoptosis by preventing mitochondrial membrane potential loss through up-regulation of the pro-survival factor BCL-2. PLoS pathogens 16, e1008297.

  • Steere, A.C., Green, J., Hutchinson, G.J., Rahn, D.W., Pachner, A.R., Schoen, R.T., Sigal, L.H., Taylor, E., Malawista, S.E., 1987. Treatment of Lyme disease. Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology 263, 352-356.

  • Sulzbacher, M.M., Sulzbacher, L.M., Passos, F.R., Bilibio, B.L.E., de Oliveira, K., Althaus, W.F., Frizzo, M.N., Ludwig, M.S., Da Cruz, I.B.M., Heck, T.G., 2022. Adapted Murine Sepsis Score:Improving the Research in Experimental Sepsis Mouse Model. BioMed research international 2022, 5700853.

  • Tariq, M., Kim, D.M., 2022. Hemorrhagic Fever with Renal Syndrome:Literature Review, Epidemiology, Clinical Picture and Pathogenesis. Infection & chemotherapy 54, 1-19.

  • Tartey, S., Takeuchi, O., 2017. Pathogen recognition and Toll-like receptor targeted therapeutics in innate immune cells. International reviews of immunology 36, 57-73.

  • Villarino, A.V., Kanno, Y., O'Shea, J.J., 2017. Mechanisms and consequences of Jak-STAT signaling in the immune system. Nat Immunol 18, 374-384.

  • Wang, K., Ma, H., Liu, H., Ye, W., Li, Z., Cheng, L., Zhang, L., Lei, Y., Shen, L., Zhang, F., 2019. The Glycoprotein and Nucleocapsid Protein of Hantaviruses Manipulate Autophagy Flux to Restrain Host Innate Immune Responses. Cell reports 27, 2075-2091.e2075.

  • Wang, P.Z., Li, Z.D., Yu, H.T., Zhang, Y., Wang, W., Jiang, W., Bai, X.F., 2012. Elevated serum concentrations of inflammatory cytokines and chemokines in patients with haemorrhagic fever with renal syndrome. The Journal of international medical research 40, 648-656.

  • Weigert, M., Binks, A., Dowson, S., Leung, E.Y.L., Athineos, D., Yu, X., Mullin, M., Walton, J.B., Orange, C., Ennis, D., Blyth, K., Tait, S.W.G., McNeish, I.A., 2017. RIPK3 promotes adenovirus type 5 activity. Cell death & disease 8, 3206.

  • Wu, J., Zhu, K., Luo, X., Han, Y., Zhang, B., Wang, Z., Dong, S., Zou, X., Chen, X., Liu, H., Wu, T., Zheng, Z., Xie, Y., Zhao, J., Liu, Y., Wen, Z., Liu, D., Wang, Y., Zheng, S., Huang, X., Jing, C., Yang, G., 2020. PM(2.5) promotes replication of VSV by ubiquitination degradation of phospho-IRF3 in A549 cells. Toxicology in vitro:an international journal published in association with BIBRA 62, 104698.

  • Xu, Z., Wei, L., Wang, L., Wang, H., Jiang, S., 2002. The in vitro and in vivo protective activity of monoclonal antibodies directed against Hantaan virus:potential application for immunotherapy and passive immunization. Biochemical and biophysical research communications 298, 552-558.

  • Yan, Y., Zhang, D., Zhou, P., Li, B., Huang, S.Y., 2017. HDOCK:a web server for protein-protein and protein-DNA/RNA docking based on a hybrid strategy. Nucleic acids research 45, W365-w373.

  • Yang, Y., Li, M., Ma, Y., Ye, W., Si, Y., Zheng, X., Liu, H., Cheng, L., Zhang, L., Zhang, H., Zhang, X., Lei, Y., Shen, L., Zhang, F., Ma, H., 2022. LncRNA NEAT1 Potentiates SREBP2 Activity to Promote Inflammatory Macrophage Activation and Limit Hantaan Virus Propagation. Frontiers in microbiology 13, 849020.

  • Ye, W., Xu, Y., Wang, Y., Dong, Y., Xi, Q., Cao, M., Yu, L., Zhang, L., Cheng, L., Wu, X., Xu, Z., Lei, Y., Zhang, F., 2015. Hantaan virus can infect human keratinocytes and activate an interferon response through the nuclear translocation of IRF-3. Infection, genetics and evolution:journal of molecular epidemiology and evolutionary genetics in infectious diseases 29, 146-155.

  • Yiang, G.T., Chen, Y.H., Chou, P.L., Chang, W.J., Wei, C.W., Yu, Y.L., 2013. The NS3 protease and helicase domains of Japanese encephalitis virus trigger cell death via caspase‑dependent and ‑independent pathways. Molecular medicine reports 7, 826-830.

  • Yin, H., Wang, Z., Yang, S., Zheng, X., Bao, Y., Lin, W., Huang, C., Qiu, L., 2022. Taurine inhibits necroptosis helps to alleviate inflammatory and injury induced by Klebsiella infection. Veterinary immunology and immunopathology 250, 110444.

  • Zhan, Q., Jeon, J., Li, Y., Huang, Y., Xiong, J., Wang, Q., Xu, T.L., Li, Y., Ji, F.H., Du, G., Zhu, M.X., 2022. CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux. Autophagy 18, 726-744.

  • Zhang, Y., Liu, B., Ma, Y., Yi, J., Zhang, C., Zhang, Y., Xu, Z., Wang, J., Yang, K., Yang, A., Zhuang, R., Jin, B., 2014. Hantaan virus infection induces CXCL10 expression through TLR3, RIG-I, and MDA-5 pathways correlated with the disease severity. Mediators of inflammation 2014, 697837.

  • Zhang, Y., Ma, R., Wang, Y., Sun, W., Yang, Z., Han, M., Han, T., Wu, X.A., Liu, R., 2021. Viruses Run:The Evasion Mechanisms of the Antiviral Innate Immunity by Hantavirus. Frontiers in microbiology 12, 759198.

  • Zhao, Q., Yu, X., Zhang, H., Liu, Y., Zhang, X., Wu, X., Xie, Q., Li, M., Ying, H., Zhang, H., 2017. RIPK3 Mediates Necroptosis during Embryonic Development and Postnatal Inflammation in Fadd-Deficient Mice. Cell reports 19, 798-808.

  • Zheng, M., Williams, E.P., Malireddi, R.K.S., Karki, R., Banoth, B., Burton, A., Webby, R., Channappanavar, R., Jonsson, C.B., Kanneganti, T.D., 2020. Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection. The Journal of biological chemistry 295, 14040-14052.