Figure 5个  Table 4
    • Table 1.  Background information of sequences used in phylogenetic analysis and mutation analysis.

    • Table 2.  Amino acid mutations leading to charge change in the alignment as classified by clades defined in Fig. 1.

    • Table 3.  Amino acid mutations leading to significant changes in pKa and hydropathy values in the alignment as classified by clades defined in Fig. 1. The shaded mutations correspond to mutations that occurred outside the main European (Europe 1) and African (Africa 3) clades

    • Table 4.  Amino acid mutations leading to charge change in the alignment as classified by clades defined in Fig. 1. The shaded mutations correspond to mutations that occurred outside the main European (Europe 1) and African (Africa 3) clades.