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Variable Group 1 Group 2 No. of studies Heterogeneity Model Overall effect Name Number/total Name Number/total P value I2 (%) P value Effect size a (95%CI) Asthma DHF 97/1686 DF 210/4359 5 0.26 23.5 Fixed 0.18 1.19 (0.92–1.54) Asthmac DHF 61/868 DF 136/2892 4 0.62 0 Fixed 0.02 1.47 (1.06–2.04) Pruritis Dengue 476/1026 Non dengue 86/385 4 0.62 0 Fixed 0 2.79 (2.08–3.73) Pruritis DHF 262/544 DF 13, 353/48, 452 2 0.02 80.7 Random 0.1 2.06 (0.87 to - 4.89) Total IgE Dengue 72 Controls 101 3 0.06 64 Random 0.006 0.78 (0.22–1.34)b Total IgE DHF 44 Controls 41 2 0.03 78 Random 0.15 0.74 (- 0.28 to 1.75)b Dengue specific Seconda 148 Primary 100 3 0.88 0 Fixed 0 1.50 (1.52–1.78)b IgE level DF DF Dengue specific Seconda 148 Secondary 132 3 0.02 74.4 Random 0.95 0.02 (- 0.48 to 0.51)b IgE level DF DHF IgE positive DHF 45/53 DF 40/79 3 0.66 0 Fixed 0.01 4.44 (1.43–13.77) Allergy (non specified) DHF 174/660 DF 1127/2491 2 0 99 Random 0.53 0.49 (0.05–4.57) Food allergy DHF 30/490 DF 51/1316 1d 0.47 0 Fixed 0.05 1.59 (1.00–2.53) Skin allergy DHF 36/490 DF 65/1316 1d 0.24 26.6 Fixed 0.05 1.53 (1.00–2.34) aOdds Ratio otherwise specifically indicated.
bSDM standard difference in means.
cSensitivity analysis after removal of Pang/2012/Singapore.
dTwo data sets from the same study were pooled.Table 1. Results of the meta-analysis testing the association between dengue and allergic signs.
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Study Allergic syndrome Compared groups Name N Value Name N Value Pvalue Koraka et al. (2003) in Indonesia (Values of total IgE and dengue-specific IgE in each groups were not described) Dengue-specific IgE Primary Dengue Infection 41 NR Secondary Dengue Infection 127 NR < 10-9 "IgE reference serum" 8 NR DHF 30 NR 0.03 "IgE reference serum" 8 NR DSS 67 NR 0.002 "Non-dengue febrile illness and healthy controls" 34 NR DF 71 NR 0.4 "Non-dengue febrile illness and healthy controls" 30 NR DHF 34 NR < 0.0001 "Non-dengue febrile illness and healthy controls" 34 NR DSS 67 NR < 0.0001 Total IgE (IU/mL) "Non-dengue febrile illness and healthy controls" 34 NR DF 71 NR 0.8 Total IgE (IU/mL) "Non-dengue febrile illness and healthy controls" 34 NR DHF 30 NR 0.539 Total IgE (IU/mL) "Non-dengue febrile illness and healthy controls" 34 NR DSS 67 NR < 0.0001 Míguez-Burbano et al. (1999) in Colombia Value : Mean ± SD Total IgE (IU/mL) Dengue IgM sero (+) 55 315.4 ± 19.9 Dengue IgM sero (-) 113 261.6 ± 5.9 0.016 Dengue IgG sero (+) 136 288.4 ± 5.9 Dengue IgG sero (-) 32 192.6 ± 9.3 0.01 Dengue IgG (+); IgM (-) NR 271.9 ± 8.5 Dengue IgG (-); IgM (-) NR 192.6 ± 34 0.01 Dengue IgG (+); IgM (+) NR 318.7 ± 1.3 Dengue IgG (-); IgM (-) NR 192.6 ± 34 0.01 Dengue IgG (-); IgM (+) NR 329.3 ± 1.3 Dengue IgG (-); IgM (-) NR 192.6 ± 34 0.01 NR not reported. Table 2. Summary of the studies that highlight the association of allergic symptoms with dengue severity that were not eligible for the meta-analysis.
Figure 5 个
Table 2 个