Figure 4个  Table 6个
    • Anti-HEV IgG (n = 4956) Anti-HEV IgM (n = 5289)
      Age, median (range) 45 (0–99) 45 (0–99)
      Male, n (%) 2666 (53.8) 2788 (52.7)
      COI, median (range) 0.28 (0–24.92) 0.1 0.01–68.49)

      Table 1.  Characteristics of study population tested for anti-HEV IgG or anti-HEV IgM.

    • Anti-HEV IgM category (n) HEV RNA detected, n (%) ALT, 9 ULN1
      Positive (243) 126 (51.9) 11.2±1.1
      Negative (375) 1 (0.3) 8.4±0.5
      Gray zone (9) 0 (0.0) 1.0±0.5
      Not available (5) 0 (0.0) 5.3±2.2
      1 Results are presented as mean ± SEM.

      Table 2.  Characteristics of samples tested for HEV RNA by real time RT-PCR.

    • HEV RNA (+) (n = 126) HEV RNA (-) (n = 117) P value
      Anti-HEV IgG COI) 10.3±0.4 11.7±0.6 0.0674
      Anti-HEV IgM (COI) 31.9±1.5 11.1±1.3 < 0.0001
      ALT, × ULN 18.2±1.8   2.1±0.4 < 0.0001
      AST, × ULN 18.4±2.7   2.4±0.3 < 0.0001
      ALP, × ULN   1.5±0.1   1.1±0.1 0.0133
      GGT, × ULN   3.5±0.2   2.2±0.5 0.0052
      TBIL, × ULN   5.6±0.5   3.8±0.7 0.0243
      1Results are presented as mean ± SEM; 2ULV: Upper limit of normal value.

      Table 3.  Comparison of anti-HEV IgM (+) patients with or without HEV RNA detected 1.

    • Parameter Value
      Male, n (%) 69 (62.2)
      Age (years), median (range) 58 (25–86)
      Baseline laboratory tests1, median (range)
        ALT, × ULN 13.6 (0.6–96.8)
        AST, × ULN 8.3 (0.6–185.7)
        ALP, × ULN 1.4 (0.5–4.2)
        GGT, × ULN 3 (0.5–12.5)
        TBIL, × ULN 4.2 (0.3–26.8)
      Symptoms2, n (%)
        Abdominal pain 21 (20.4)
        Anorexia 70 (68.0)
        Fever 29 (28.2)
        Jaundice 78 (75.7)
        Malaise 49 (47.6)
        Nausea 44 (42.7)
        Vomiting 29 (28.2)
      Concomitant liver disease2, n (%)
        Alcoholic fatty liver disease 5 (4.9)
        Non-alcoholic fatty liver disease 17 (16.5)
        HBV carriage 13 (12.6)
      1106 patients had available ALT, AST, ALP and GGT test results and 105 patients had available TBIL result at presentation to our hospital
      2Information of symptoms and concomitant liver disease was available for 103 inpatients.

      Table 4.  Characteristics of laboratory-confirmed cases of HEV infection.

    • Variables Length of hospital stay
      Univariate   Multivariate
      β Coefficient P value β Coefficient P value
      Age 4.40 0.0384
      Anti-HEV IgG 4.30 0.0408
      Anti-HEV IgM 0.22 0.6389 7.83 0.0062
      HBsAg (±) 1.41 0.2383
      ALT/ULN 0.01 0.9391
      AST/ULN 0.00 0.9628
      ALP/ULN 5.94 0.0166
      GGT/ULN 2.16 0.1447
      TBIL/ULN 74.80 < 0.0001 87.33 < 0.0001

      Table 5.  Univariate and multivariate linear regression analysis for variables associating with the length of hospital stay.

    • Parameter HBsAg (+) (n = 13) HBsAg (-)(n = 89) P value
      Age (years) 54.4 ± 3. 5 55.5 ± 1.5 0.7526
      Discharge days 24.2 ± 4.0 18.4 ± 1.8 0.0318
      ALT, × ULN 16.6 ± 5.6 21.3 ± 2.1 0.3099
      AST, × ULN 25.1 ± 9.5 20.8 ± 3.3 0.7191
      ALP, × ULN   1.7 ± 0.2   1.5 ± 0.1   0.5041
      GGT, × ULN   3.2 ± 0.5   3.8 ± 0.3   0.6391
      TBIL, × ULN   8.0 ± 2.0   5.4 ± 0.4   0.2403
      1Results are presented as mean ± SEM

      Table 6.  Demographic and baseline clinical parameters comparison of inpatients with or without HBV carriage1.