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Baker, J.M., Buchfellner, M., Britt, W., Sanchez, V., Potter, J.L., Ingram, L.A., Shiau, H., Gutierrez Sanchez, L.H., Saaybi, S., Kelly, D., Lu, X., Vega, E.M., Ayers-Millsap, S., Willeford, W.G., Rassaei, N., Bullock, H., Reagan-Steiner, S., Martin, A., Moulton, E.A., Lamson, D.M., St George, K., Parashar, U.D., Hall, A.J., Macneil, A., Tate, J.E., Kirking, H.L., 2022. Acute hepatitis and adenovirus infection among children -Alabama, october 2021-february 2022. MMWR Morb. Mortal. Wkly. Rep. 71, 638-640.

Bril, F., Al Diffalha, S., Dean, M., Fettig, D.M., 2021. Autoimmune hepatitis developing after coronavirus disease 2019 (COVID-19) vaccine:causality or casualty? J. Hepatol. 75, 222-224.

Brodin, P., 2022. SARS-CoV-2 infections in children:understanding diverse outcomes. Immunity 55, 201-209.

Brodin, P., Arditi, M., 2022. Severe acute hepatitis in children:investigate SARS-CoV-2 superantigens. Lancet Gastroenterol Hepatol 7, 594-595.

Chertow, D., Stein, S., Ramelli, S., Grazioli, A., Kleiner, D., 2021. SARS-CoV-2 infection and persistence throughout the human body and brain. Research Square. https://doi.org/10.21203/rs.3.rs-1139035/v1.

ECDC-WHO, 2022. Joint ECDC-WHO/Europe surveillance bulletin:hepatitis of unknown origin in children[Online]. Available:https://www.ecdc.europa.eu/en/hepatitis/joint-weekly-hepatitis-unknown-origin-children-surveillance-bulletin. (Accessed 1 June 2022).

Gao, Y., Li, Q., Shi, H., Feng, Y., Zhang, T., Chen, Y., Liang, L., Chen, D., Wu, H., Jin, R., Huang, X., 2020. Preliminary exploration of the cause of liver disorders during early stages in COVID-19 patients. Front. Med. 7, 501.

Gouma, S., Hahné, S.J., Gijselaar, D.B., Koopmans, M.P., Van Binnendijk, R.S., 2016. Severity of mumps disease is related to MMR vaccination status and viral shedding. Vaccine 34, 1868-1873.

Guan, G.W., Gao, L., Wang, J.W., Wen, X.J., Mao, T.H., Peng, S.W., Zhang, T., Chen, X.M., Lu, F.M., 2020. Exploring the mechanism of liver enzyme abnormalities in patients with novel coronavirus-infected pneumonia. Zhonghua Gan Zang Bing Za Zhi 28, 100-106 (In Chinese).

Hoofnagle, J.H., Björnsson, E.S., 2019. Drug-induced liver injury-types and phenotypes. N. Engl. J. Med. 381, 264-273.

Ke, R., Martinez, P.P., Smith, R.L., Gibson, L.L., Achenbach, C.J., Mcfall, S., Qi, C., Jacob, J., Dembele, E., Bundy, C., Simons, L.M., Ozer, E.A., Hultquist, J.F., LorenzoRedondo, R., Opdycke, A.K., Hawkins, C., Murphy, R.L., Mirza, A., Conte, M., Gallagher, N., Luo, C.H., Jarrett, J., Conte, A., Zhou, R., Farjo, M., Rendon, G., Fields, C.J., Wang, L., Fredrickson, R., Baughman, M.E., Chiu, K.K., Choi, H., Scardina, K.R., Owens, A.N., Broach, J., Barton, B., Lazar, P., Robinson, M.L., Mostafa, H.H., Manabe, Y.C., Pekosz, A., Mcmanus, D.D., Brooke, C.B., 2021.Longitudinal analysis of SARS-CoV-2 vaccine breakthrough infections reveal limited infectious virus shedding and restricted tissue distribution. medRxiv. https://doi.org/10.1101/2021.08.30.21262701.

Kouo, T., Chaisawangwong, W., 2021. SARS-CoV-2 as a superantigen in multisystem inflammatory syndrome in children. J. Clin. Invest. 131, e149327.

Lai, Y.C., Cheng, Y.W., Chao, C.H., Chang, Y.Y., Chen, C.D., Tsai, W.J., Wang, S., Lin, Y.S., Chang, C.P., Chuang, W.J., Chen, L.Y., Wang, Y.R., Chang, S.Y., Huang, W., Wang, J.R., Tseng, C.K., Lin, C.K., Chuang, Y.C., Yeh, T.M., 2022. Antigenic cross-reactivity between SARS-CoV-2 S1-RBD and its receptor ACE2. Front. Immunol. 13, 868724.

Lynch 3_rd, J.P., Kajon, A.E., 2021. Adenovirus:epidemiology, global spread of novel types, and approach to treatment. Semin. Respir. Crit. Care Med. 42, 800-821.

Mallapaty, S., 2022. Most US kids have caught the coronavirus, antibody survey finds. Nature 605, 207.

Mcconnell, M.J., Kawaguchi, N., Kondo, R., Sonzogni, A., Licini, L., Valle, C., Bonaffini, P.A., Sironi, S., Alessio, M.G., Previtali, G., Seghezzi, M., Zhang, X., Lee, A.I., Pine, A.B., Chun, H.J., Zhang, X., Fernandez-Hernando, C., Qing, H., Wang, A., Price, C., Sun, Z., Utsumi, T., Hwa, J., Strazzabosco, M., Iwakiri, Y., 2021. Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy. J. Hepatol. 75, 647-658.

Miller, A.D., Zambrano, L.D., Yousaf, A.R., Abrams, J.Y., Meng, L., Wu, M.J., Melgar, M., Oster, M.E., Godfred Cato, S.E., Belay, E.D., Campbell, A.P., 2021. Multisystem inflammatory syndrome in children-United States, february 2020-july 2021. Clin. Infect. Dis. 5, ciab1007.

Moreews, M., Le Gouge, K., Khaldi-Plassart, S., Pescarmona, R., Mathieu, A.L., Malcus, C., Djebali, S., Bellomo, A., Dauwalder, O., Perret, M., Villard, M., Chopin, E., Rouvet, I., Vandenesh, F., Dupieux, C., Pouyau, R., Teyssedre, S., Guerder, M., Louazon, T., Moulin-Zinsch, A., Duperril, M., Patural, H., Giovannini-Chami, L., Portefaix, A., Kassai, B., Venet, F., Monneret, G., Lombard, C., Flodrops, H., De Guillebon, J.M., Bajolle, F., Launay, V., Bastard, P., Zhang, S.Y., Dubois, V., Thaunat, O., Richard, J.C., Mezidi, M., Allatif, O., Saker, K., Dreux, M., Abel, L., Casanova, J.L., Marvel, J., Trouillet-Assant, S., Klatzmann, D., Walzer, T., Mariotti-Ferrandiz, E., Javouhey, E., Belot, A., 2021. Polyclonal expansion of TCR vbeta 21.3(+) CD4(+) and CD8(+) T cells is a hallmark of multisystem inflammatory syndrome in children. Sci Immunol 6, eabh1516.

Natarajan, A., Zlitni, S., Brooks, E.F., Vance, S.E., Dahlen, A., Hedlin, H., Park, R.M., Han, A., Schmidtke, D.T., Verma, R., Jacobson, K.B., Parsonnet, J., Bonilla, H.F., Singh, U., Pinsky, B.A., Andrews, J.R., Jagannathan, P., Bhatt, A.S., 2022. Gastrointestinal symptoms and fecal shedding of SARS-CoV-2 RNA suggest prolonged gastrointestinal infection. Med. Off. 3, 371-387.e9.

Nygaard, U., Holm, M., Hartling, U.B., Glenthøj, J., Schmidt, L.S., Nordly, S.B., Matthesen, A.T., Von Linstow, M.L., Espenhain, L., 2022. Incidence and clinical phenotype of multisystem inflammatory syndrome in children after infection with the SARS-CoV-2 delta variant by vaccination status:a Danish nationwide prospective cohort study. Lancet Child Adolesc Health 6, 459-465.

PAHO/WHO, 2022. Acute, severe hepatitis of unknown origin in children. 10 May 2022[Online]. Available:https://www.paho.org/en/documents/acute-severe-hepatitis-un known-origin-children-10-may-2022. (Accessed 26 May 2022).

Ronan, B.A., Agrwal, N., Carey, E.J., De Petris, G., Kusne, S., Seville, M.T., Blair, J.E., Vikram, H.R., 2014. Fulminant hepatitis due to human adenovirus. Infection 42, 105-111.

Saviano, A., Baumert, T.F., 2021. Unraveling the role of liver sinusoidal endothelial cells in COVID-19 liver injury. J. Hepatol. 75, 503-505.

Schaberg, K.B., Kambham, N., Sibley, R.K., Higgins, J.P.T., 2017. Adenovirus hepatitis:clinicopathologic analysis of 12 consecutive cases from a single institution. Am. J. Surg. Pathol. 41, 810-819.

Toscano, G., Palmerini, F., Ravaglia, S., Ruiz, L., Invernizzi, P., Cuzzoni, M.G., Franciotta, D., Baldanti, F., Daturi, R., Postorino, P., Cavallini, A., Micieli, G., 2020. Guillain-barrésyndrome associated with SARS-CoV-2. N. Engl. J. Med. 382, 2574-2576.

UKHSA, 2022a. Increase in hepatitis (liver inflammation) cases in children under investigation[Online]. Available:https://www.gov.uk/government/news/incre ase-in-hepatitis-liver-inflammation-cases-in-children-under-investigation. (Accessed 1 June 2022).

UKHSA, 2022b. Technical briefing 2:investigation into acute hepatitis of unknown aetiology in children in England[Online]. Available:https://assets.publishing.se rvice.gov.uk/government/uploads/system/uploads/attachment_data/file/1073704/acute-hepatitis-technical-briefing-2.pdf. (Accessed 26 May 2022).

UKHSA, 2022c. Technical briefing 3:investigation into acute hepatitis of unknown aetiology in children in England[Online]. Available:https://assets.publishing.se rvice.gov.uk/government/uploads/system/uploads/attachment_data/file/1077027/acute-hepatitis-technical-briefing_3.pdf. (Accessed 26 May 2022).

Vojdani, A., Kharrazian, D., 2020. Potential antigenic cross-reactivity between SARS-CoV-2 and human tissue with a possible link to an increase in autoimmune diseases. Clin.Immunol. 217, 08480.

Wang, Y., Liu, S., Liu, H., Li, W., Lin, F., Jiang, L., Li, X., Xu, P., Zhang, L., Zhao, L., Cao, Y., Kang, J., Yang, J., Li, L., Liu, X., Li, Y., Nie, R., Mu, J., Lu, F., Zhao, S., Lu, J., Zhao, J., 2020. SARS-CoV-2 infection of the liver directly contributes to hepatic impairment in patients with COVID-19. J. Hepatol. 73, 807-816.

Who, 2022. Acute hepatitis of unknown aetiology in children-multi-country[Online]. Available:https://www.who.int/emergencies/disease-outbreak-news/item/DON-389. (Accessed 1 June 2022).

Zollner, A., Koch, R., Jukic, A., Pfister, A., Meyer, M., Rössler, A., Kimpel, J., Adolph, T.E., Tilg, H., 2022. Post-acute COVID-19 is characterized by gut viral antigen persistence in inflammatory bowel diseases. Gastroenterology S0016-5085 (22), 00450-00454.

Zulfiqar, A.A., Lorenzo-Villalba, N., Hassler, P., Andrès, E., 2020. Immune thrombocytopenic purpura in a patient with covid-19. N. Engl. J. Med. 382, e43.