Figure 2个  Table 1个
    • Flavivirus restriction vs. sensing
      ● Do some flavivirus restriction factors also function as sensors?
      IFI6
      ● Does IFI6 engage in direct contacts with flaviviral targets?
      Viperin
      ● Is the enzymatic activity of viperin constitutive or triggered by interactions with viral motifs?
      ● Do mammalian cells encode other enzymes involved in the synthesis of natural nucleotide analogs with antiviral activity?
      ● Could the antiviral effect of the viperin enzymatic activity serve as a guide toward the development of novel nucleoside analog pharmaceuticals?
      Cytoplasmic TRIMs
      ● What are the precise viral and TRIM molecular determinants of flavivirus restriction specificity?
      ● Is there a functional human homolog of TRIM79α able to target the NS5 protein of flaviviruses toward a degradation pathway?
      ● Is the restriction of incoming flaviviruses by cytoplasmic TRIMs a coordinated response involving TRIM-TRIM interactions?
      RNA-targeting factors
      ● Are there functional interactions between the various flaviviral RNA-binding restriction factors?
      ● What is the basis for selective flavivirus species RNA recognition by human OAS proteins?
      ● Does human ABCF3 contribute to OAS-mediated restriction of flaviviruses?
      TRIM19 (PML)
      ● What is the mechanism by which TRIM19 decreases susceptibility to DENV?
      Escape from restriction
      ● Do flaviviruses escape some restriction factors through direct targeting by viral proteins?
      ● Do flaviviruses other than DENV disrupt TRIM19 nuclear bodies?

      Table Box 1.  Unanswered questions in the restriction of flaviviruses.