Figure 4个  Table 1个
    • Conventional cell lines Organoids CRC
      Sample size Surgical Small to big Tiny to big
      Timing 1–5 months 1–5 weeks 1–10 days
      Success rate of initiation (%) (0–10) ++ (5–80) +++ (50–100)
      Rapid expansion +++ ++ +++
      Karyotypic stability + ++ ++
      3D growth – ++ –
      Genetic manipulation +++ ++ ++
      Low throughput drug screens +++ ++ +++
      High throughput drug screens +++ ++ +++
      Heterogeneity − ++ ++
      Cell biology + +++ +++
      Cost + ++ +
      "–" "+" "++" and "+++" indicate "unsuitable or not applicable", "possible", "suitable", and "best" for the aspects or applications except for "cost". "+" and "++" represent "low" and "high" for in "cost" line, respectively.

      Table 1.  Comparison of ex vivo cell models.