• Affo, S., Yu, L. X. & Schwabe, R. F. 2017. The role of cancer-associated fibroblasts and fibrosis in liver cancer. Annu. Rev. Pathol., 12, 153-186.

  • Ayub, A., Ashfaq, U. A. & Haque, A. 2013. HBV induced HCC: major risk factors from genetic to molecular level. BioMed Res. Int., 2013, 810461.

  • Belloni, L., Pollicino, T., DE Nicola, F., Guerrieri, F., Raffa, G., Fanciulli, M., Raimondo, G. & Levrero, M. 2009. Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function. Proc Natl Acad Sci U S A, 106, 19975-19979.

  • Bhan, A., Soleimani, M. & Mandal, S. S. 2017. Long noncoding RNA and cancer: a new paradigm. Cancer Res., 77, 3965-3981.

  • Bian, D., Gao, C., Bao, K. & Song, G. 2017. The long non-coding RNA NKILA inhibits the invasion-metastasis cascade of malignant melanoma via the regulation of NF-kB. Am. J. Cancer Res., 7, 28-40.

  • Bird, L. 2018. lncRNA NKILA: a killer regulator. Nat. Rev. Immunol., 18, 666-667.

  • Bui-Nguyen, T. M., Pakala, S. B., Sirigiri, R. D., Xia, W., Hung, M. C., Sarin, S. K., Kumar, V., Slagle, B. L. & Kumar, R. 2010. NF-kappaB signaling mediates the induction of MTA1 by hepatitis B virus transactivator protein HBx. Oncogene, 29, 1179-1189.

  • Chen, J., Zhang, W., Lin, J., Wang, F., Wu, M., Chen, C., Zheng, Y., Peng, X., Li, J. & Yuan, Z. 2014. An efficient antiviral strategy for targeting hepatitis B virus genome using transcription activator-like effector nucleases. Mol. Ther., 22, 303-311.

  • Chen, R., Cheng, Q., Owusu-Ansah, K. G., Song, G., Jiang, D., Zhou, L., Xu, X., Wu, J. & Zheng, S. 2020. NKILA, a prognostic indicator, inhibits tumor metastasis by suppressing NF-kappaB/Slug mediated epithelial-mesenchymal transition in hepatocellular carcinoma. Int. J. Biol. Sci., 16, 495-503.

  • Chong, C. K., Cheng, C. Y. S., Tsoi, S. Y. J., Huang, F. Y., Liu, F., Seto, W. K., Lai, C. L., Yuen, M. F. & Wong, D. K. 2017. Role of hepatitis B core protein in HBV transcription and recruitment of histone acetyltransferases to cccDNA minichromosome. Antivir. Res., 144, 1-7.

  • Dijkstra, J. M. & Alexander, D. B. 2015. The " NF-k B interacting long noncoding RNA" (NKILA) transcript is antisense to cancer-associated gene PMEPA1. F1000Res, 4, 96.

  • Du, Y., Su, T., Ding, Y. & Cao, G. 2012. Effects of antiviral therapy on the recurrence of hepatocellular carcinoma after curative resection or liver transplantation. Hepat. Mon., 12, e6031.

  • Duan, L., Wu, R., Zhang, X., Wang, D., You, Y., Zhang, Y., Zhou, L. & Chen, W. 2018. HBx-induced S100A9 in NF-kappaB dependent manner promotes growth and metastasis of hepatocellular carcinoma cells. Cell Death Dis., 9, 629.

  • Feng, G. X., Li, J., Yang, Z., Zhang, S. Q., Liu, Y. X., Zhang, W. Y., Ye, L. H. & Zhang, X. D. 2017. Hepatitis B virus X protein promotes the development of liver fibrosis and hepatoma through downregulation of miR-30e targeting P4HA2 mRNA. Oncogene, 36, 6895-6905.

  • Feng, J., Yang, G., Liu, Y., Gao, Y., Zhao, M., Bu, Y., Yuan, H., Yuan, Y., Yun, H., Sun, M., Gao, H., Zhang, S., Liu, Z., Yin, M., Song, X., Miao, Z., Lin, Z. & Zhang, X. 2019. LncRNA PCNAP1 modulates hepatitis B virus replication and enhances tumor growth of liver cancer. Theranostics, 9, 5227-5245.

  • Hoesel, B. & Schmid, J. A. 2013. The complexity of NF-kappaB signaling in inflammation and cancer. Mol. Cancer, 12, 86.

  • Hsieh, Y. H., Su, I. J., Yen, C. J., Tsai, T. F., Tsai, H. W., Tsai, H. N., Huang, Y. J., Chen, Y. Y., Ai, Y. L., Kao, L. Y., Hsieh, W. C., Wu, H. C. & Huang, W. 2013. Histone deacetylase inhibitor suberoylanilide hydroxamic acid suppresses the pro-oncogenic effects induced by hepatitis B virus pre-S2 mutant oncoprotein and represents a potential chemopreventive agent in high-risk chronic HBV patients. Carcinogenesis, 34, 475-485.

  • Huan, C., Li, Z., Ning, S., Wang, H., Yu, X. F. & Zhang, W. 2018. Long noncoding RNA uc002yug.2 activates HIV-1 latency through regulation of mRNA levels of various RUNX1 isoforms and increased tat expression. J. Virol., 92.

  • Huang, G., Li, P. P., Lau, W. Y., Pan, Z. Y., Zhao, L. H., Wang, Z. G., Wang, M. C. & Zhou, W. P. 2018. Antiviral therapy reduces hepatocellular carcinoma recurrence in patients with low HBV-DNA levels: a randomized controlled trial. Ann. Surg., 268, 943-954.

  • Huang, W., Cui, X., Chen, J., Feng, Y., Song, E., Li, J. & Liu, Y. 2016. Long non-coding RNA NKILA inhibits migration and invasion of tongue squamous cell carcinoma cells via suppressing epithelial-mesenchymal transition. Oncotarget, 7, 62520-62532.

  • Ji, J., Ding, K., Luo, T., Xu, R., Zhang, X., Huang, B., Chen, A., Zhang, D., Miletic, H., Bjerkvig, R., Thorsen, F., Wang, J. & Li, X. 2020. PMEPA1 isoform a drives progression of glioblastoma by promoting protein degradation of the Hippo pathway kinase LATS1. Oncogene, 39, 1125-1139.

  • Jiang, M., Zhang, S., Yang, Z., Lin, H., Zhu, J., Liu, L., Wang, W., Liu, S., Liu, W., Ma, Y., Zhang, L. & Cao, X. 2018. Self-recognition of an inducible host lncRNA by RIG-I feedback restricts innate immune response. Cell, 173, 906-919 e13.

  • Kakumani, P. K., Guitart, T., Houle, F., Harvey, L. M., Goyer, B., Germain, L., Gebauer, F. & Simard, M. J. 2021. CSDE1 attenuates microRNA-mediated silencing of PMEPA1 in melanoma. Oncogene, 40, 3231-3244.

  • Ladner, S. K., Otto, M. J., Barker, C. S., Zaifert, K., Wang, G. H., Guo, J. T., Seeger, C. & King, R. W. 1997. Inducible expression of human hepatitis B virus (HBV) in stably transfected hepatoblastoma cells: a novel system for screening potential inhibitors of HBV replication. Antimicrob. Agents Chemother., 41, 1715-1720.

  • Lamontagne, R. J., Bagga, S. & Bouchard, M. J. 2016. Hepatitis B virus molecular biology and pathogenesis. Hepatoma Res, 2, 163-186.

  • Lei, Y., Xu, X., Liu, H., Chen, L., Zhou, H., Jiang, J., Yang, Y. & Wu, B. 2021. HBx induces hepatocellular carcinogenesis through ARRB1-mediated autophagy to drive the G1/S cycle. Autophagy, 17, 4423-4441.

  • Levrero, M., Pollicino, T., Petersen, J., Belloni, L., Raimondo, G. & Dandri, M. 2009. Control of cccDNA function in hepatitis B virus infection. J. Hepatol., 51, 581-592.

  • Li, J., Chen, C., Ma, X., Geng, G., Liu, B., Zhang, Y., Zhang, S., Zhong, F., Liu, C., Yin, Y., Cai, W. & Zhang, H. 2016a. Long noncoding RNA NRON contributes to HIV-1 latency by specifically inducing tat protein degradation. Nat. Commun., 7, 11730.

  • Li, Z., Zhao, X., Jiang, P., Xiao, S., Wu, G., Chen, K., Zhang, X., Liu, H., Han, X., Wang, S. & Li, X. 2016b. HBV is a risk factor for poor patient prognosis after curative resection of hepatocellular carcinoma: a retrospective case-control study. Medicine (Baltim.), 95, e4224.

  • Liu, B., Sun, L., Liu, Q., Gong, C., Yao, Y., Lv, X., Lin, L., Yao, H., Su, F., Li, D., Zeng, M. & Song, E. 2015. A cytoplasmic NF-kappaB interacting long noncoding RNA blocks IkappaB phosphorylation and suppresses breast cancer metastasis. Cancer Cell, 27, 370-381.

  • Liu, R., Zhou, Z., Huang, J. & Chen, C. 2011. PMEPA1 promotes androgen receptor-negative prostate cell proliferation through suppressing the Smad3/4-c-Myc-p21 Cip1 signaling pathway. J. Pathol., 223, 683-694.

  • Lu, Z., Li, Y., Wang, J., Che, Y., Sun, S., Huang, J., Chen, Z. & He, J. 2017. Long non-coding RNA NKILA inhibits migration and invasion of non-small cell lung cancer via NF-kappaB/Snail pathway. J. Exp. Clin. Cancer Res., 36, 54.

  • Majano, P., Lara-Pezzi, E., Lopez-Cabrera, M., Apolinario, A., Moreno-Otero, R. & Garcia-Monzon, C. 2001. Hepatitis B virus X protein transactivates inducible nitric oxide synthase gene promoter through the proximal nuclear factor kappaB-binding site: evidence that cytoplasmic location of X protein is essential for gene transactivation. Hepatology, 34, 1218-1224.

  • Mulero, M. C., Huxford, T. & Ghosh, G. 2019. NF-kappaB, IkappaB, and IKK: integral components of immune system signaling. Adv. Exp. Med. Biol., 1172, 207-226.

  • Nojima, T. & Proudfoot, N. J. 2022. Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics. Nat. Rev. Mol. Cell Biol., 23, 389-406.

  • Oeckinghaus, A. & Ghosh, S. 2009. The NF-kappaB family of transcription factors and its regulation. Cold Spring Harbor Perspect. Biol., 1, a000034.

  • Pollicino, T., Belloni, L., Raffa, G., Pediconi, N., Squadrito, G., Raimondo, G. & Levrero, M. 2006. Hepatitis B virus replication is regulated by the acetylation status of hepatitis B virus cccDNA-bound H3 and H4 histones. Gastroenterology, 130, 823-837.

  • Riviere, L., Gerossier, L., Ducroux, A., Dion, S., Deng, Q., Michel, M. L., Buendia, M. A., Hantz, O. & Neuveut, C. 2015. HBx relieves chromatin-mediated transcriptional repression of hepatitis B viral cccDNA involving SETDB1 histone methyltransferase. J. Hepatol., 63, 1093-1102.

  • Salerno, D., Chiodo, L., Alfano, V., Floriot, O., Cottone, G., Paturel, A., Pallocca, M., Plissonnier, M. L., Jeddari, S., Belloni, L., Zeisel, M., Levrero, M. & Guerrieri, F. 2020. Hepatitis B protein HBx binds the DLEU2 lncRNA to sustain cccDNA and host cancer-related gene transcription. Gut, 69, 2016-2024.

  • Schiffer, J. T., Aubert, M., Weber, N. D., Mintzer, E., Stone, D. & Jerome, K. R. 2012. Targeted DNA mutagenesis for the cure of chronic viral infections. J. Virol., 86, 8920-8936.

  • Sekiba, K., Otsuka, M., Funato, K., Miyakawa, Y., Tanaka, E., Seimiya, T., Yamagami, M., Tsutsumi, T., Okushin, K., Miyakawa, K., Ryo, A. & Koike, K. 2022. HBx-induced degradation of Smc5/6 complex impairs homologous recombination-mediated repair of damaged DNA. J. Hepatol., 76, 53-62.

  • Shokri, S., Mahmoudvand, S., Taherkhani, R., Farshadpour, F. & Jalalian, F. A. 2019. Complexity on modulation of NF-kappaB pathways by hepatitis B and C: a double-edged sword in hepatocarcinogenesis. J. Cell. Physiol.

  • Shukla, R., Yue, J., Siouda, M., Gheit, T., Hantz, O., Merle, P., Zoulim, F., Krutovskikh, V., Tommasino, M. & Sylla, B. S. 2011. Proinflammatory cytokine TNF-alpha increases the stability of hepatitis B virus X protein through NF-kappaB signaling. Carcinogenesis, 32, 978-985.

  • Sohn, W., Paik, Y. H., Cho, J. Y., Ahn, J. M., Choi, G. S., Kim, J. M., Kwon, C. H., Joh, J. W., Sinn, D. H., Gwak, G. Y., Choi, M. S., Lee, J. H., Koh, K. C., Paik, S. W. & Yoo, B. C. 2015. Influence of hepatitis B virus reactivation on the recurrence of HBV-related hepatocellular carcinoma after curative resection in patients with low viral load. J. Viral Hepat., 22, 539-550.

  • Song, W., Zheng, C., Liu, M., Xu, Y., Qian, Y., Zhang, Z., Su, H., Li, X., Wu, H., Gong, P., Li, Y. & Fan, H. 2021. TRERNA1 upregulation mediated by HBx promotes sorafenib resistance and cell proliferation in HCC via targeting NRAS by sponging miR-22-3p. Mol. Ther., 29, 2601-2616.

  • Sunami, Y., Ringelhan, M., Kokai, E., Lu, M., O'Connor, T., Lorentzen, A., Weber, A., Rodewald, A. K., Mullhaupt, B., Terracciano, L., Gul, S., Wissel, S., Leithauser, F., Krappmann, D., Riedl, P., Hartmann, D., Schirmbeck, R., Strnad, P., Huser, N., Kleeff, J., Friess, H., Schmid, R. M., Geisler, F., Wirth, T. & Heikenwalder, M. 2016. Canonical NF-kappaB signaling in hepatocytes acts as a tumor-suppressor in hepatitis B virus surface antigen-driven hepatocellular carcinoma by controlling the unfolded protein response. Hepatology, 63, 1592-1607.

  • Tan, Y. T., Lin, J. F., Li, T., Li, J. J., Xu, R. H. & Ju, H. Q. 2021. LncRNA-mediated posttranslational modifications and reprogramming of energy metabolism in cancer. Cancer Commun., 41, 109-120.

  • Urabe, A., Imamura, M., Tsuge, M., Kan, H., Fujino, H., Fukuhara, T., Masaki, K., Kobayashi, T., Ono, A., Nakahara, T., Kawaoka, T., Hiramatsu, A., Kawakami, Y., Aikata, H., Hayes, C. N., Maki, N., Ohdan, H. & Chayama, K. 2017. The relationship between HBcrAg and HBV reinfection in HBV related post-liver transplantation patients. J. Gastroenterol., 52, 366-375.

  • Vallabhapurapu, S. & Karin, M. 2009. Regulation and function of NF-kappaB transcription factors in the immune system. Annu. Rev. Immunol., 27, 693-733.

  • Wang, H., Liu, Y., Huan, C., Yang, J., Li, Z., Zheng, B., Wang, Y. & Zhang, W. 2020. NF-kappaB-Interacting long noncoding RNA regulates HIV-1 replication and latency by repressing NF-kappaB signaling. J. Virol., 94.

  • Wang, J., Zhang, Y., Li, Q., Zhao, J., Yi, D., Ding, J., Zhao, F., Hu, S., Zhou, J., Deng, T., Li, X., Guo, F., Liang, C. & Cen, S. 2019. Influenza virus exploits an interferon-independent lncRNA to preserve viral RNA synthesis through stabilizing viral RNA polymerase PB1. Cell Rep., 27, 3295-3304 e4.

  • Wong, C. M., Tsang, F. H. & Ng, I. O. 2018. Non-coding RNAs in hepatocellular carcinoma: molecular functions and pathological implications. Nat. Rev. Gastroenterol. Hepatol., 15, 137-151.

  • Wu, X., Cai, B., Lu, W., Fu, Y., Wei, B., Niu, Q., Su, Z., Li, Y. & Wang, L. 2021. HBV upregulated triggering receptor expressed on myeloid cells-1 (TREM-1) expression on monocytes participated in disease progression through NF-Kb pathway. Clin Immunol, 223, 108650.

  • Xiang, W. Q., Feng, W. F., Ke, W., Sun, Z., Chen, Z. & Liu, W. 2011. Hepatitis B virus X protein stimulates IL-6 expression in hepatocytes via a MyD88-dependent pathway. J. Hepatol., 54, 26-33.

  • Yang, T., Li, S., Liu, J., Yin, D., Yang, X. & Tang, Q. 2018. lncRNA-NKILA/NF-kappaB feedback loop modulates laryngeal cancer cell proliferation, invasion, and radioresistance. Cancer Med., 7, 2048-2063.

  • Yoo, S., Wang, W., Wang, Q., Fiel, M. I., Lee, E., Hiotis, S. P. & Zhu, J. 2017. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med., 15, 214.

  • Yu, X., Lan, P., Hou, X., Han, Q., Lu, N., Li, T., Jiao, C., Zhang, J., Zhang, C. & Tian, Z. 2017. HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1beta production via suppressing the NF-kappaB pathway and ROS production. J. Hepatol., 66, 693-702.

  • Yu, X., Tang, W., Yang, Y., Tang, L., Dai, R., Pu, B., Feng, C. & Xia, J. 2018. Long noncoding RNA NKILA enhances the anti-cancer effects of baicalein in hepatocellular carcinoma via the regulation of NF-kappaB signaling. Chem. Biol. Interact., 285, 48-58.

  • Yuan, H., Zhao, L., Yuan, Y., Yun, H., Zheng, W., Geng, Y., Yang, G., Wang, Y., Zhao, M. & Zhang, X. 2021. HBx represses WDR77 to enhance HBV replication by DDB1-mediated WDR77 degradation in the liver. Theranostics, 11, 8362-8378.

  • Zhang, Q., Lenardo, M. J. & Baltimore, D. 2017. 30 Years of NF-kappaB: a blossoming of relevance to human pathobiology. Cell, 168, 37-57.

  • Zhang, R., Li, J., Li, G., Jin, F., Wang, Z., Yue, R., Wang, Y., Wang, X. & Sun, Y. 2020. LncRNA Nron regulates osteoclastogenesis during orthodontic bone resorption. Int. J. Oral Sci., 12, 14.

  • Zheng, B., Zhang, J., Zheng, T., Wang, H., Li, Z., Huan, C., Ning, S., Wang, Y. & Zhang, W. 2020. ATP1B3 cooperates with BST-2 to promote hepatitis B virus restriction. J. Med. Virol., 92, 201-209.