-
Bakkers, M.J.G., Cox, F., Koornneef, A., Yu, X., Van Overveld, D., Le, L., Van Den Hoogen, W., Vaneman, J., Thoma, A., Voorzaat, R., Tettero, L., Juraszek, J., Van Der Fits, L., Zahn, R., Langedijk, J.P.M., 2024a. A foldon-free prefusion F trimer vaccine for respiratory syncytial virus to reduce off-target immune responses. Nat Microbiol, 9, 3254-3267.
-
Bakkers, M.J.G., Ritschel, T., Tiemessen, M., Dijkman, J., Zuffiano, A.A., Yu, X., Van Overveld, D., Le, L., Voorzaat, R., Van Haaren, M.M., De Man, M., Tamara, S., Van Der Fits, L., Zahn, R., Juraszek, J., Langedijk, J.P.M., 2024b. Efficacious human metapneumovirus vaccine based on AI-guided engineering of a closed prefusion trimer. Nat Commun, 15, 6270.
-
Banerjee, A., Huang, J., Rush, S.A., Murray, J., Gingerich, A.D., Royer, F., Hsieh, C.L., Tripp, R.A., Mclellan, J.S., Mousa, J.J., 2022. Structural basis for ultrapotent antibody-mediated neutralization of human metapneumovirus. Proc Natl Acad Sci U S A, 119, e2203326119.
-
Battles, M.B., Mas, V., Olmedillas, E., Cano, O., Vazquez, M., Rodriguez, L., Melero, J.A., Mclellan, J.S., 2017. Structure and immunogenicity of pre-fusion-stabilized human metapneumovirus F glycoprotein. Nat Commun, 8, 1528.
-
Che, Y., Gribenko, A.V., Song, X., Handke, L.D., Efferen, K.S., Tompkins, K., Kodali, S., Nunez, L., Prasad, A.K., Phelan, L.M., et al., 2023. Rational design of a highly immunogenic prefusion-stabilized F glycoprotein antigen for a respiratory syncytial virus vaccine. Sci Transl Med, 15, eade6422.
-
Corti, D., Bianchi, S., Vanzetta, F., Minola, A., Perez, L., Agatic, G., Guarino, B., Silacci, C., Marcandalli, J., Marsland, B.J., Piralla, A., Percivalle, E., Sallusto, F., Baldanti, F., Lanzavecchia, A., 2013. Cross-neutralization of four paramyxoviruses by a human monoclonal antibody. Nature, 501, 439-443.
-
Delgado, M.F., Coviello, S., Monsalvo, A.C., Melendi, G.A., Hernandez, J.Z., Batalle, J.P., Diaz, L., Trento, A., Chang, H.Y., Mitzner, W., Ravetch, J., Melero, J.A., Irusta, P.M., Polack, F.P., 2009. Lack of antibody affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease. Nat Med, 15, 34-41.
-
Green, M.G., Huey, D., Niewiesk, S., 2013. The cotton rat (Sigmodon hispidus) as an animal model for respiratory tract infections with human pathogens. Lab Anim (NY), 42, 170-176.
-
Guo, L., Li, L., Liu, L., Zhang, T., Sun, M., 2023. Neutralising antibodies against human metapneumovirus. Lancet Microbe, 4, e732-e744.
-
Hamelin, M.E., Abed, Y., Boivin, G., 2004. Human metapneumovirus: a new player among respiratory viruses. Clin Infect Dis, 38, 983-990.
-
Hsieh, C.L., Rush, S.A., Palomo, C., Chou, C.W., Pickens, W., Mas, V., Mclellan, J.S., 2022. Structure-based design of prefusion-stabilized human metapneumovirus fusion proteins. Nat Commun, 13, 1299.
-
Huang, J., Chopra, P., Liu, L., Nagy, T., Murray, J., Tripp, R.A., Boons, G.J., Mousa, J.J., 2021. Structure, Immunogenicity, and Conformation-Dependent Receptor Binding of the Postfusion Human Metapneumovirus F Protein. J Virol, 95, e0059321.
-
Huang, J., Diaz, D., Mousa, J.J., 2019. Antibody Epitopes of Pneumovirus Fusion Proteins. Front Immunol, 10, 2778.
-
Kapandji, N., Darmon, M., Valade, S., Salmona, M., Legoff, J., Zafrani, L., Azoulay, E., Lemiale, V., 2023. Clinical significance of human metapneumovirus detection in critically ill adults with lower respiratory tract infections. Ann Intensive Care, 13, 21.
-
Kishko, M., Stuebler, A., Sasmal, S., Chan, Y., Huang, D., Reyes, C., Lin, J., Price, O., Kume, A., Zong, K., Bricault, C., Alamares-Sapuay, J., Zhang, L., 2025. A Computationally Designed Prefusion Stabilized Human Metapneumovirus Fusion Protein Vaccine Antigen Elicited a Potent Neutralization Response. Vaccines (Basel), 13, 523.
-
Knudson, C.J., Hartwig, S.M., Meyerholz, D.K., Varga, S.M., 2015. RSV vaccine-enhanced disease is orchestrated by the combined actions of distinct CD4 T cell subsets. PLoS Pathog, 11, e1004757.
-
Li, Y., Pillai, P., Miyake, F., Nair, H., 2020. The role of viral co-infections in the severity of acute respiratory infections among children infected with respiratory syncytial virus (RSV): A systematic review and meta-analysis. J Glob Health, 10, 010426.
-
Lianou, A., Tsantes, A.G., Ioannou, P., Bikouli, E.D., Batsiou, A., Kokkinou, A., Tsante, K.A., Tsilidis, D., Lampridou, M., Iacovidou, N., Sokou, R., 2025. hMPV Outbreaks: Worldwide Implications of a Re-Emerging Respiratory Pathogen. Microorganisms, 13, 1508.
-
Mas, V., Rodriguez, L., Olmedillas, E., Cano, O., Palomo, C., Terron, M.C., Luque, D., Melero, J.A., Mclellan, J.S., 2016. Engineering, Structure and Immunogenicity of the Human Metapneumovirus F Protein in the Postfusion Conformation. PLoS Pathog, 12, e1005859.
-
Mclellan, J.S., Chen, M., Leung, S., Graepel, K.W., Du, X., Yang, Y., Zhou, T., Baxa, U., Yasuda, E., Beaumont, T., Kumar, A., Modjarrad, K., Zheng, Z., Zhao, M., Xia, N., Kwong, P.D., Graham, B.S., 2013. Structure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody. Science, 340, 1113-1117.
-
Mousa, J.J., Binshtein, E., Human, S., Fong, R.H., Alvarado, G., Doranz, B.J., Moore, M.L., Ohi, M.D., Crowe, J.E., Jr., 2018. Human antibody recognition of antigenic site IV on Pneumovirus fusion proteins. PLoS Pathog, 14, e1006837.
-
Munoz-Escalante, J.C., Mata-Moreno, G., Rivera-Alfaro, G., Noyola, D.E., 2022. Global Extension and Predominance of Human Metapneumovirus A2 Genotype with Partial G Gene Duplication. Viruses, 14, 1058.
-
Ngwuta, J.O., Chen, M., Modjarrad, K., Joyce, M.G., Kanekiyo, M., Kumar, A., Yassine, H.M., Moin, S.M., Killikelly, A.M., Chuang, G.Y., et al., 2015. Prefusion F-specific antibodies determine the magnitude of RSV neutralizing activity in human sera. Sci Transl Med, 7, 309ra162.
-
Ou, L., Chen, S.J., Teng, I.T., Yang, L., Zhang, B., Zhou, T., Biju, A., Cheng, C., Kong, W.P., Morano, N.C., et al., 2023. Structure-based design of a single-chain triple-disulfide-stabilized fusion-glycoprotein trimer that elicits high-titer neutralizing responses against human metapneumovirus. PLoS Pathog, 19, e1011584.
-
Panda, S., Mohakud, N.K., Pena, L., Kumar, S., 2014. Human metapneumovirus: review of an important respiratory pathogen. Int J Infect Dis, 25, 45-52.
-
Polack, F.P., Teng, M.N., Collins, P.L., Prince, G.A., Exner, M., Regele, H., Lirman, D.D., Rabold, R., Hoffman, S.J., Karp, C.L., Kleeberger, S.R., Wills-Karp, M., Karron, R.A., 2002. A role for immune complexes in enhanced respiratory syncytial virus disease. J Exp Med, 196, 859-865.
-
Rappazzo, C.G., Hsieh, C.L., Rush, S.A., Esterman, E.S., Delgado, T., Geoghegan, J.C., Wec, A.Z., Sakharkar, M., Mas, V., Mclellan, J.S., Walker, L.M., 2022. Potently neutralizing and protective anti-human metapneumovirus antibodies target diverse sites on the fusion glycoprotein. Immunity, 55, 1710-1724.e1718.
-
Ryder, A.B., Tollefson, S.J., Podsiad, A.B., Johnson, J.E., Williams, J.V., 2010. Soluble recombinant human metapneumovirus G protein is immunogenic but not protective. Vaccine, 28, 4145-4152.
-
Skiadopoulos, M.H., Biacchesi, S., Buchholz, U.J., Amaro-Carambot, E., Surman, S.R., Collins, P.L., Murphy, B.R., 2006. Individual contributions of the human metapneumovirus F, G, and SH surface glycoproteins to the induction of neutralizing antibodies and protective immunity. Virology, 345, 492-501.
-
Soto, J.A., Galvez, N.M.S., Benavente, F.M., Pizarro-Ortega, M.S., Lay, M.K., Riedel, C., Bueno, S.M., Gonzalez, P.A., Kalergis, A.M., 2018. Human Metapneumovirus: Mechanisms and Molecular Targets Used by the Virus to Avoid the Immune System. Front Immunol, 9, 2466.
-
Tang, J.W.T., 2025. Brothers in arms: RSV and hMPV. Lancet Healthy Longev, 6, 100684.
-
Terstappen, J., Hak, S.F., Bhan, A., Bogaert, D., Bont, L.J., Buchholz, U.J., Clark, A.D., Cohen, C., Dagan, R., Feikin, D.R., et al., 2024. The respiratory syncytial virus vaccine and monoclonal antibody landscape: the road to global access. Lancet Infect Dis, 24, e747-e761.
-
Van Den Hoogen, B.G., De Jong, J.C., Groen, J., Kuiken, T., De Groot, R., Fouchier, R.A., Osterhaus, A.D., 2001. A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med, 7, 719-724.
-
Wang, X., Li, Y., Deloria-Knoll, M., Madhi, S.A., Cohen, C., Ali, A., Basnet, S., Bassat, Q., Brooks, W.A., Chittaganpitch, M., et al., 2021. Global burden of acute lower respiratory infection associated with human metapneumovirus in children under 5 years in 2018: a systematic review and modelling study. Lancet Glob Health, 9, e33-e43.
-
Wen, X., Krause, J.C., Leser, G.P., Cox, R.G., Lamb, R.A., Williams, J.V., Crowe, J.E., Jr., Jardetzky, T.S., 2012. Structure of the human metapneumovirus fusion protein with neutralizing antibody identifies a pneumovirus antigenic site. Nat Struct Mol Biol, 19, 461-463.
-
Wen, X., Mousa, J.J., Bates, J.T., Lamb, R.A., Crowe, J.E., Jr., Jardetzky, T.S., 2017. Structural basis for antibody cross-neutralization of respiratory syncytial virus and human metapneumovirus. Nat Microbiol, 2, 16272.
-
Williams, J.V., Tollefson, S.J., Johnson, J.E., Crowe, J.E., Jr., 2005. The cotton rat (Sigmodon hispidus) is a permissive small animal model of human metapneumovirus infection, pathogenesis, and protective immunity. J Virol, 79, 10944-10951.
-
Xiao, X., Fridman, A., Zhang, L., Pristatsky, P., Durr, E., Minnier, M., Tang, A., Cox, K.S., Wen, Z., Moore, R., et al., 2022. Profiling of hMPV F-specific antibodies isolated from human memory B cells. Nat Commun, 13, 2546.
-
Yu, D., Zhang, C., Qi, Y., Liu, Z., Yang, D., Zhao, N., Ke, Z., Lu, X., Li, Y., 2025. RSV Vaccines: Targeting Prefusion F and G Proteins from Structural Design to Clinical Application. Vaccines (Basel), 13, 1133.
-
Zhang, Y., Niewiesk, S., Li, J., 2014. Small Animal Models for Human Metapneumovirus: Cotton Rat is More Permissive than Hamster and Mouse. Pathogens, 3, 633-655.
-
Zhao, H., Feng, Q., Feng, Z., Zhu, Y., Ai, J., Xu, B., Deng, L., Sun, Y., Li, C., Jin, R., Shang, Y., Chen, X., Xu, L., Xie, Z., 2022. Clinical characteristics and molecular epidemiology of human metapneumovirus in children with acute lower respiratory tract infections in China, 2017 to 2019: A multicentre prospective observational study. Virol Sin, 37, 874-882.