Figure 5个  Table 2个
    • Year Province Strain name Genotype References
      2011 Jiangsu A/Jiangsu/1/2011 1 Yang et al. (2012)
      2012 Hebei A/Hebei-Yuhua/SWL1250/2012 1 Wang et al. (2013)
      2015 Hunan A/Hunan/42443/2015 3 Zhu et al. (2016)
      2015 Yunnan A/Yunnan-Longyang/SWL1982/2015 3 Zhu et al. (2019)
      2015 Yunnan A/Yunnan-Wuhua/SWL1869/2015 3 Zhu et al. (2019)
      2016 Fujian A/Fujian-Cangshan/SWL624/2016 5 Xie et al. (2018)

      Table 1.  Human cases infected with EA H1N1 SIVs in China.

    • Gene Phenotypic characteristic(s) Mutation Percentage
      HAa Altered the receptor specificity E190D E (0%) D (85.9%)
      G225E G (12.7%) E (84.1%)
      NAb Resistance to NA inhibitors H274Y H (100%) Y (0%)
      N294S N (100%) S (0%)
      PB2 Altered the virulence in mice D9N D (98.1%) N (1.1%)
      L89V L (0.4%) V (98.9%)
      E158G E (100%) G (0%)
      Mammalian host adaption D256G D (100%) G (0%)
      Enhance viral polymerase activity T271A T (68%) A (30.8%)
      Enhance the 627 k and 701 N function K526R K (94.4%) R (5.6%)
      Restored the polymerase activity M535L M (100%) L (0%)
      Enhance the viral polymerase activity, Q591K Q (66.2%) K (0.4%)
      increase the virulence in mice E627K E (98.5%) K (0.4%)
      D701N D (30%) N (70%)
      Altered the virulence in mice A676T A (2.2%) T (96%)
      PB1 Enhance the viral polymerase activity L473V L (0.4%) V (99.6%)
      Altered the virulence in mice R198K R (0.8%) K (99.2%)
      PA Enhance the viral polymerase activity L336M L (72.9%) M (26.8%)
      Enhance the viral polymerase activity, increase the virulence in mice K356R K (74.4%) R (25.7%)
      Species-associated signature positions S409N S (17.5%) N (81.0%)
      NP Enhance the viral polymerase activity A150R A (0%) R (98.9%)
      Enhance the viral polymerase activity, N319K N (85.6%) K (14.4%)
      altered the virulence in mice Q357K Q (66.7%) K (31.5%)
      M1 Increase the transmission in guinea pigs P41A P (0%) A (98.6%)
      Altered the virulence in mice T215A T (0%) A (100%)
      M2 Resistance to adamantine derivatives S31N S (0.7%) N (98.9%)
      NS1 Altered the virulence in mice D92E D (97.1%) E (1.5%)
      Altered the antiviral response in host N205S N (10.2%) S (54.2%)
      G210R G (12.7%) R (56.7%)
      aThe H3 numbering system was used.
      bThe N2 numbering system was used.

      Table 2.  Prevalence of key molecular markers in EA H1N1 SIVs in China.