-
Assiri, McGeer, Perl, Price, Al Rabeeah, Cummings, Alabdullatif, Assad, Almulhim, Makhdoom, Madani, Alhakeem, Al-Tawfiq, Cotton, Watson, Kellam, Zumla, Memish, KSA MERS-CoV Investigation Team, 2013: Hospital outbreak of Middle East respiratory syndrome coronavirus[J]. N Engl J Med, 369, 407-416. doi: 10.1056/NEJMoa1306742
-
Baez-Santos YM, Barraza SJ, Wilson MW, Agius MP, Mielech AM, Davis NM, Baker SC, Larsen SD, Mesecar AD, 2014a: X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases[J]. J Med Chem, 57, 2393-2412. doi: 10.1021/jm401712t
-
Baez-Santos YM, Mielech AM, Deng X, Baker S, Mesecar AD, 2014b: Catalytic function and substrate specificity of the PLpro domain of nsp3 from the Middle East Respiratory Syndrome Coronavirus (MERS-CoV)[J]. J Virol, 88, 12511-12527. doi: 10.1128/JVI.01294-14
-
Bailey-Elkin BA, Knaap RC, Johnson GG, Dalebout TJ, Ninaber DK, van Kasteren PB, Bredenbeek PJ, Snijder EJ, Kikkert M, Mark BL, 2014: Crystal structure of the Middle East respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppression[J]. J Biol Chem, 289, 34667-34682. doi: 10.1074/jbc.M114.609644
-
Barretto N, Jukneliene D, Ratia K, Chen Z, Mesecar AD, Baker SC, 2005: The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity[J]. J Virol, 79, 15189-15198. doi: 10.1128/JVI.79.24.15189-15198.2005
-
Bekes M, Rut W, Kasperkiewicz P, Mulder MP, Ovaa H, Drag M, Lima CD, Huang TT, 2015: SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme[J]. Biochem J, 468, 215-226. doi: 10.1042/BJ20141170
-
Butler D, 2015: South Korean MERS outbreak spotlights lack of research[J]. Nature, 522, 139-140. doi: 10.1038/522139a
-
Chang CK, Hou MH, Chang CF, Hsiao CD, Huang TH, 2014: The SARS coronavirus nucleocapsid protein-forms and functions[J]. Antiviral Res, 103, 39-50. doi: 10.1016/j.antiviral.2013.12.009
-
Chen VB, Arendall WB, Headd JJ, Keedy DA, Immormino RM, Kapral GJ, Murray LW, Richardson JS, Richardson DC, 2010: MolProbity: all-atom structure validation for macromolecular crystallography[J]. Acta Crystallogr D Biol Crystallogr, 66, 12-21. doi: 10.1107/S0907444909042073
-
Chen Y, Cai H, Pan J, Xiang N, Tien P, Ahola T, Guo D, 2009: Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase[J]. Proc Natl Acad Sci USA, 106, 3484-3489. doi: 10.1073/pnas.0808790106
-
Chou CY, Lai HY, Chen HY, Cheng SC, Cheng KW, Chou YW, 2014: Structural basis for catalysis and ubiquitin recognition by the severe acute respiratory syndrome coronavirus papain-like protease[J]. Acta Crystallogr D Biol Crystallogr, 70, 572-581.
-
Dikic I, Wakatsuki S, Walters KJ, 2009: Ubiquitin-binding domains-from structures to functions[J]. Nat Rev Mol Cell Biol, 10, 659-671.
-
Drosten C, Günther S, Preiser W, van der Werf S, Brodt HR, Becker S, Rabenau H, Panning M, Kolesnikova L, Fouchier RA, Berger A, Burguiere AM, Cinatl J, Eickmann M, Escriou N, Grywna K, Kramme S, Manuguerra JC, Müller S, Rickerts V, Stürmer M, Vieth S, Klenk HD, Osterhaus AD, Schmitz H, Doerr HW, 2003: Identification of a novel coronavirus in patients with severe acute respiratory syndrome[J]. N Engl J Med, 348, 1967-1976. doi: 10.1056/NEJMoa030747
-
Eckerle I, Müller MA, Kallies S, Gotthardt DN, Drosten C, 2013: In-vitro renal epithelial cell infection reveals a viral kidney tro-pism as a potential mechanism for acute renal failure during Middle East Respiratory Syndrome (MERS) coronavirus infection[J]. Virol J, 10, 359-. doi: 10.1186/1743-422X-10-359
-
Emsley P, Lohkamp B, Scott WG, Cowtan K, 2010: Features and development of Coot[J]. Acta Crystallogr D Biol Crystallogr, 66, 486-501. doi: 10.1107/S0907444910007493
-
Fetics SK, Guterres H, Kearney BM, Buhrman G, Ma B, Nussinov R, Mattos C, 2015: Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD[J]. Structure, 23, 505-516. doi: 10.1016/j.str.2014.12.017
-
Frieman M, Ratia K, Johnston RE, Mesecar AD, Baric RS, 2009: Severe acute respiratory syndrome coronavirus papain-like protease ubiquitin-like domain and catalytic domain regulate antago-nism of IRF3 and NF-κB signaling[J]. J Virol, 83, 6689-6705. doi: 10.1128/JVI.02220-08
-
Hale BG, Randall RE, Ortin J, Jackson D, 2008: The multifunctional NS1 protein of influenza A viruses[J]. J Gen Virol, 89, 2359-2376. doi: 10.1099/vir.0.2008/004606-0
-
Hamre D, Procknow JJ, 1966: A new virus isolated from the human respiratory tract[J]. Proc Soc Exp Biol Med, 121, 190-193. doi: 10.3181/00379727-121-30734
-
Harcourt BH, Jukneliene D, Kanjanahaluethai A, Bechill J, Severson KM, Smith CM, Rota PA, Baker SC, 2004: Identification of severe acute respiratory syndrome coronavirus replicase products and characterization of papain-like protease activity[J]. J Virol, 78, 13600-13612. doi: 10.1128/JVI.78.24.13600-13612.2004
-
Headd JJ, Echols N, Afonine PV, Grosse-Kunstleve RW, Chen VB, Moriarty NW, Richardson DC, Richardson JS, Adams PD, 2012: Use of knowledge-based restraints in phenix.refine to improve macromolecular refinement at low resolution[J]. Acta Crystallogr D Biol Crystallogr, 68, 381-390. doi: 10.1107/S0907444911047834
-
Hilgenfeld R, 2014: From SARS to MERS: Crystallographic studies on coronaviral proteases enable antiviral drug design[J]. FEBS J, 281, 4085-4096. doi: 10.1111/febs.2014.281.issue-18
-
Hilgenfeld R, Peiris M, 2013: From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses[J]. Antiviral Res, 100, 286-295. doi: 10.1016/j.antiviral.2013.08.015
-
Hu M, Li P, Song L, Jeffrey PD, Chenova TA, Wilkinson KD, Cohen RE, Shi Y, 2005: Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14[J]. EMBO J, 24, 3747-3756. doi: 10.1038/sj.emboj.7600832
-
Kabsch W, 2010: XDS[J]. Acta Crystallogr D Biol Crystallogr, 66, 125-132. doi: 10.1107/S0907444909047337
-
Krissinel E, Henrick K, 2007: Inference of macromolecular assemblies from crystalline state[J]. J Mol Biol, 372, 774-797. doi: 10.1016/j.jmb.2007.05.022
-
Ksiazek TG, Erdman D, Goldsmith CS, Zaki SR, Peret T, Emery S, Tong S, Urbani C, Comer JA, Lim W, Rollin PE, Dowell SF, Ling AE, Humphrey CD, Shieh WJ, Guarner J, Paddock CD, Rota P, Fields B, DeRisi J, Yang JY, Cox N, Hughes JM, LeDuc JW, Bellini WJ, Anderson LJ, SARS Working Group, 2003: A novel coronavirus associated with severe acute respira-tory syndrome[J]. N Engl J Med, 348, 1953-1966. doi: 10.1056/NEJMoa030781
-
Kuiken T, Fouchier RA, Schutten M, Rimmelzwaan GF, van Amerongen G, van Riel D, Laman JD, de Jong T, van Doornum G, Lim W, Ling AE, Chan PK, Tam JS, Zambon MC, Gopal R, Drosten C, van der Werf S, Escriou N, Manuguerra JC, Stöhr K, Peiris JS, Osterhaus AD, 2003: Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome[J]. Lancet, 362, 263-270. doi: 10.1016/S0140-6736(03)13967-0
-
Lee H, Lei H, Santarsiero BD, Gatuz JL, Cao S, Rice AJ, Patel K, Szypulinski MZ, Ojeda I, Ghosh AK, Johnson ME, 2015: Inhibi-tor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV[J]. ACS Chem Biol, 10, 1456-1465. doi: 10.1021/cb500917m
-
Lei J, Mesters JR, Drosten C, Anemüller S, Ma Q, Hilgenfeld R, 2014: Crystal structure of the papain-like protease of MERS-coronavirus reveals unusual, potentially druggable active-site features[J]. Antiviral Res, 109, 72-82. doi: 10.1016/j.antiviral.2014.06.011
-
Liu YC, Penninger J, Karin M, 2005: Immunity by ubiquitylation: a reversible process of modification[J]. Nat Rev Immunol, 5, 941-952. doi: 10.1038/nri1731
-
Maringer K, Fernandez-Sesma A, 2014: Message in a bottle: lessons learned from antagonism of STING signalling during RNA virus infection[J]. Cytokine Growth Factor Rev, 25, 669-679. doi: 10.1016/j.cytogfr.2014.08.004
-
McIntosh K, Becker WB, Chanock RM, 1967: Growth in suckling-mouse brain of "IBV-like" viruses from patients with upper respiratory tract disease[J]. Proc Natl Acad Sci USA, 58, 2268-2273. doi: 10.1073/pnas.58.6.2268
-
Mielech AM, Kilianski A, Baez-Santos YM, Mesecar AD, Baker SC, 2014: MERS-CoV papain-like protease has delSGylating and deubiquitinating activities[J]. Virology, 450-451, 64-70. doi: 10.1016/j.virol.2013.11.040
-
Mielech AM, Deng X, Chen Y, Kindler E, Wheeler DL, Mesecar AD, Thiel V, Perlman S, Baker SC, 2015: Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis[J]. J Virol, 89, 4907-4917. doi: 10.1128/JVI.00338-15
-
Mueller U, Darowski N, Fuchs MR, F?rster R, Hellmig M, Paithankar KS, Pühringer S, Steffien M, Zocher G, Weiss MS, 2012: Facilities for macromolecular crystallography at the Helmholtz-Zentrum Berlin[J]. J Synchrotron Radiat, 19, 442-449. doi: 10.1107/S0909049512006395
-
Peiris JS, Lai ST, Poon LL, Guan Y, Yam LY, Lim W, Nicholls J, Yee WK, Yan WW, Cheung MT, Cheng VC, Chan KH, Tsang DN, Yung RW, Ng TK, Yuen KY, SARS Study Group, 2003: Coronavirus as a possible cause of severe acute respiratory syndrome[J]. Lancet, 361, 1319-1325. doi: 10.1016/S0140-6736(03)13077-2
-
Pfoh R, Lacdao IK, Georges AA, Capar A, Zheng H, Frappier L, Saridakis V, 2015: Crystal structure of USP7 ubiquitin-like domains with an ICP0 peptide reveals a novel mechanism used by viral and cellular proteins to target USP7[J]. PLoS Pathog, 11, e1004950-. doi: 10.1371/journal.ppat.1004950
-
Ratia K, Kilianski A, Baez-Santos YM, Baker SC, Mesecar AD, 2014: Structural basis for the ubiquitin-linkage specificity and deISGylating activity of SARS-CoV papain-like protease[J]. PLoS Pathog, 10, e1004113-. doi: 10.1371/journal.ppat.1004113
-
Vagin A, Teplyakov A, 2010: Molecular replacement with MOLREP[J]. Acta Crystallogr D Biol Crystallogr, 66, 22-25.
-
van der Hoek L, Pyrc K, Jebbink MF, Vermeulen-Oost W, Berkhout RJ, Wolthers KC, Wertheim-van Dillen PM, Kaandorp J, Spaargaren J, Berkhout B, 2004: Identification of a new human coronavirus[J]. Nat Med, 10, 368-373. doi: 10.1038/nm1024
-
Vijay-Kumar S, Bugg CE, Cook WJ, 1987: Structure of ubiquitin refined at 1.8 Å resolution[J]. J Mol Biol, 194, 531-534. doi: 10.1016/0022-2836(87)90679-6
-
Wang H, Xue S, Yang H, Chen C, 2016: Recent progress in the discovery of inhibitors targeting coronavirus proteases[J]. Virol Sin, 31, 24-30. doi: 10.1007/s12250-015-3711-3
-
Weiss MS, Hilgenfeld R, 1997: On the use of the merging R factor as a quality indicator for X-ray data[J]. J Appl Cryst, 30, 203-205. doi: 10.1107/S0021889897003907
-
Wojdyla JA, Manolaridis I, van Kasteren PB, Kikkert M, Snijder EJ, Gorbalenya AE, Tucker PA, 2010: Papain-like protease 1 from transmissible gastroenteritis virus: crystal structure and enzymatic activity toward viral and cellular substrates[J]. J Virol, 84, 10063-10073. doi: 10.1128/JVI.00898-10
-
Woo PC, Lau SK, Chu CM, Chan KH, Tsoi HW, Huang Y, Wong BH, Poon RW, Cai JJ, Luk WK, Poon LL, Wong SS, Guan Y, Peiris JS, Yuen KY, 2005: Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia[J]. J Virol, 79, 884-895. doi: 10.1128/JVI.79.2.884-895.2005
-
Yang X, Chen X, Bian G, Tu J, Xing Y, Wang Y, Chen Z, 2013: Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papain-like protease[J]. J Gen Virol, 95, 614-626.
-
Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA, 2012: Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia[J]. N Engl J Med, 367, 1814-1820. doi: 10.1056/NEJMoa1211721