-
-
-
Compound name IC50-MARV(lmol/L) IC50-VSV(lmol/L) CC50(lmol/L) SI = CC50/IC50 VSV/MARV Pharmacological classes Chloroquine phosphate 1.7 53.6 > 200 > 116.1 31.1 Antimalarial Amodiaquine hydrochloride 1.4 19.5 79.3 56.6 13.9 Antimalarial Mianserin hydrochloride 5.4 74.8 > 200 > 37.3 13.9 Antidepressant Diltiazem hydrochloride 6.8 53.6 > 200 > 29.4 7.9 Vasodilator, antiarrhythmic Imipramine hydrochloride 5.3 38.2 152.3 28.6 7.2 Antidepressant Pizotyline 4.4 32.7 99.3 22.4 7.4 Prevent migraine; antidepressant Sertraline hydrochloride 1.6 26.3 33.8 21 16.3 Antidepressant Promethazine hydrochloride 4.7 45 94.3 20.1 9.6 Antihistamine Budesonide 9.9 > 66.7 > 66.7 > 20.1 > 6.7 Corticosteroid Tolterodine tartrate 10.3 88.8 > 200 > 19.4 8.6 Antimuscarinic Propafenone hydrochloride 5.3 53.8 102.2 19.3 10.2 Antiarrhythmic Defluoroxy paroxetine 5.2 40.7 101.2 19.3 7.8 Antidepressant Azelastine hydrochloride 6.2 33.3 99.5 16.1 5.4 Histamine antagonist Trihexyphenidyl hydrochloride 12.7 58.4 > 66.7 > 15.8 4.6 Antimuscarinic antiparkinsonian Propiverine hydrochloride 6.4 34.5 94.5 14.7 5.4 Muscarinic antagonist Phencynonate hydrochloride 10 48.9 146.3 14.6 4.9 Antimuscarinic Amitriptyline hydrochloride 6.5 43.7 93.2 14.3 6.7 Antidepressant Flutamide 14.6 > 200 > 200 > 13.7 > 13.7 Nonsteroidal antiandrogen Benproperine phosphate 6 30.4 82.4 13.7 5.1 Antitussive Cloperastine hydrochloride 6.5 35.8 84.5 12.9 5.5 Antitussive antihistamine Dicyclomine hydrochloride 9.3 48.7 114.9 12.3 5.2 Antimuscarinic Haloperidol 14.5 82.3 163.9 11.3 5.7 Antipsychotic Oxybutynin chloride 10.9 34.1 109.9 10 3.1 Antimuscarinic N-methylparoxetine 10.4 43.3 103 9.9 4.2 Antidepressant Ketotifen fumarate 23.7 108.7 > 200 > 8.4 4.6 Antihistamine Terfenadine 1 8.8 8.7 8.3 8.4 Antihistamine Clemastine fumarate 7.1 34.6 58.6 8.3 4.9 Antihistamine anticholinergic Fluphenazine 9.7 58.5 > 66.7 > 6.8 6 Antipsychotic Fluoxertine hydrochloride 5.7 35.8 37.4 6.6 6.3 Antipsychotic Paroxetine hydrochloride 5.1 28.2 33 6.4 5.5 Antidepressant Astemizole 1.9 9.3 11.1 5.8 4.9 Antihistamine Flupenthixol hydrochloride 6.8 26.1 34 5 3.8 Antipsychotic Amlodipine besylate 7.8 28 35.1 4.5 3.6 Calcium channel blocker, antihypertensive Table 1. In vitro anti-MARV activity of 33 hit compounds.
Figure 2 个
Table 1 个
