Figure 2个  Table 2个
    • Case Common information Clinical manifestation
      Age (y) Sex Occupation Contact history Place of infection Year Fever Respiratory failure Headache Pneumonia Visual impairment Seizures Disturbance of consciousness Viral encephalitis Ocular inflammation
      1 38 Male Butcher Injury Shandong 2017 Yes Yes Yes Yes Yes Yes Yes Yes N.A
      2 55 Male Pork dealer Pork Inner Mongolia 2017 Yes Yes No Yes Yes Yes Yes Yes N.A
      3 51 Male Cook Pork Inner Mongolia 2017 Yes Yes Yes Yes No Yes Yes Yes N.A
      4 42 Female Butcher Pigs/pork Hebei 2016 Yes No No No Yes Yes Yes Yes Yes
      5 46 Female Swineherd Sewage Jiangxi 2017 Yes No Yes No Yes No No No Yes
      6 44 Male Sick pig handler Diseased pigs; pork Shandong 2019 Yes Yes No Yes Yes Yes Yes Yes Yes
      7 59 Male Swineherd Needle injury Hebei 2019 Yes No No No Yes Yes Yes Yes N.A
      8 50 Male Butcher Injury at work Shandong 2018 Yes No Yes Yes No Yes Yes Yes N.A
      9 50 Female Pork cutter Injury at work Shandong 2018 Yes Yes Yes Yes No Yes Yes Yes N.A
      10 43 Male Sick pig handler Injury at work Shandong 2018 Yes Yes No Yes Yes Yes Yes Yes N.A
      11 59 Male Pork cutter Injury at work Shandong 2018 Yes Yes No Yes No Yes Yes Yes N.A
      12 50 Male Pork cutter N.A Shandong 2018 Yes Yes No Yes Yes Yes Yes Yes N.A
      13 46 Male Veterinarian Injury/ dead pigs Shandong 2018 Yes No Yes No No Yes Yes Yes N.A
      14 25 Male Veterinarian Diseased pigs Hubei 2018 Yes No Yes Yes Yes Yes Yes Yes N.A
      15 25 Male Butcher Pigs/pork Henan 2019 Yes Yes Yes Yes No Yes Yes Yes N.A
      16 49 Male Butcher Pork Henan 2019 Yes Yes Yes Yes No Yes Yes Yes N.A
      17 43 Male Veterinarian Diseased pigs Shandong 2018 Yes Yes Yes Yes No Yes Yes Yes N.A
      18 44 Male Pork vendor Injury Anhui 2019 Yes Yes No No Yes Yes Yes Yes N.A
      19 N.A Male Butcher N.A Shandong 2018 Yes Yes N.A Yes N.A Yes Yes Yes N.A
      20 N.A Male Swineherd N.A Hebei 2018 Yes Yes N.A Yes Yes Yes Yes Yes N.A
      21 N.A Male Driver N.A Guangdong 2018 Yes Yes N.A Yes N.A Yes Yes Yes N.A
      22 N.A Female Pork dealer N.A Beijing 2011 Yes Yes N.A Yes N.A Yes Yes Yes N.A
      23 49 Male Slaughterer N.A Anhui 2019 Yes N.A Yes N.A Yes Yes Yes Yes Yes
      Case Diagnosis Clinical outcome References
      Vitreous humor (NGS) Cerebrospinal fluid (NGS) Antibody (ELISA)
      1 N.A + + Minimally conscious state Zhao et al. (2018)
      2 N.A + + Death
      3 N.A + + Death
      4 N.A N.A N.A Minimally conscious state; Blindness
      5 + - + Visually impaired Ai et al. (2018)
      6 + + N.A Persistent vegetative state; Visually impaired Wang et al. (2019)
      7 N.A + + Follow simple instructions; Mild cognitive deficit; Blindness Zheng et al. (2019)
      8 N.A + N.A Slow responses, Occasional seizures Yang X et al. (2019)
      9 N.A + N.A Ventilator-dependent
      10 N.A + N.A Follow simple instructions; Blurry vision
      11 N.A + N.A Ventilator-dependent
      12 N.A + N.A Slow responses; Blindness
      13 N.A + + N.A Yang H et al. (2019)
      14 - + + Blindness Liu et al. (2020)
      15 - + + Mild memory impairment
      16 - + + Minimally conscious state
      17 - + + Persistent vegetative state
      18 N.A + + Follow simple instructions; blurry vision Wang et al. (2020)
      19 N.A + + Death Fan et al. (2020)
      20 N.A + + Memory loss and bilateral hand tremor; Visual impairment
      21 N.A + + Follow simple instructions
      22 N.A + - Death
      23 + N.A N.A N.A Hu et al. (2020)
      N.A. not available.

      Table 1.  Summary information of the human PRV infection cases in China.

    • Year Sample level Farm level
      Sample numbers gE-Positive numbers Sero-prevalence rate (%) Farm numbers gE-Positive numbers Sero-prevalence rate (%)
      2014 8244 3509 42.6 436 331 76.0
      2015 5304 2838 53.5 316 246 78.0
      2016 7179 2654 37.0 381 259 68.0
      2017 7028 2801 39.9 342 237 69.3
      2018 4052 1605 39.6 264 186 70.5
      2019 1107 439 39.7 79 55 69.6

      Table 2.  Sero-prevalence of PRV-gE in central China from 2014 to 2019.