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Proteins Substitutionsa Functions SZ-SMGC-1 Pakistan-06 Other strains from China Amino acids No. (%) nsp1 T128K NA K K K 21 (95.5) T 1 (4.5) nsp2 S54N NA N N N 21 (95.5) S 1(4.5) H374Y NA Y Y Y 21 (95.5) H 1 (4.5) L539S NA L L L 12 (54.5) S 10(46.5) nsp3 524 NA Stop codon R Stop codon 20 (909) R 2 (9.1) nsp4 L43A NA A A A 22 (100) L 0 0) R82S NA R R R 12 (54.5) S 10(46.5) T254A NA A A A 21(95.5) T 1(4.5) A 366T NA T T T 21(95.5) A 1(4.5) Q500L NA L L L 22 (100) Q 0 (0) E2 A164T NA T T T 22 (100) A 0(0) I211T Potentiate the ECSA genotype for the finess-increasing effect of A226V T T T 21 (95.5) I 1 (4.5) K252Q Enhance the infection eficiency to A. albopictus K K K 10 (46.5) Q 12 (54.5) V386A NA A A A 21 (95.5) V 1 (4.5) E1 S72N NA N N N 22 (100) S 0(0) E211K NA E E E 7 (31.8) K 15 (68.2) A226V Increased fitness to the A. albopictus A A A 10 (46.5) V 12 (54.5) D284E Influence the icosahedral E1-scaffold and increase transmissibility E E E 21 (95.5) D 1 (4.5) NA not available, ECSA East Central
aSouth African."Specific substitutions for viruses from ECSA lineage were shown.Table 1. Key amino acid substitutions of the SZ-SMGC-1 and the other isolates in China.
Figure 2 个
Table 1 个