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Protein Function p17 Matrix protein; plasma membrane targeting of Gag for virion assembly; envelope incorporation; facilitates HIV-1 core into the cell nucleus; promotes proliferation and proinflammatory cytokines release p24 Capsid protein assembly into virion core structure p6 Vpr incorporation; virion budding p7 Encapsulates and protects viral genomic RNA; recognizes HIV-1 packaging signal of viral RNA RT RNA-dependent and DNA-dependent polymerase activity for cDNA synthesis RNase H Degrades RNA template strand from RNA/DNA duplex PR Proteolytic processing of Gag and Gag-pol polyproteins IN Catalyzes viral cDNA integration into the host cellular chromosome Rev Induces nuclear export of intron-containing viral RNAs; induces the transition from early to late phase of HIV-1 gene expression Tat Viral transcriptional transactivator; represses cellular promoters gp120 Interacts with CD4 receptor and chemokine co-receptors; mediates virus attachment and entry gp41 Non-covalently bound to gp120; mediates membrane fusion and virus entry Vpu CD4/MHC downregulation in endoplasmic reticulum; promotes virion release from host cell surface Vpr Promotes nuclear localization of preintegration complex; induces G2/M cell cycle arrest Vif Suppresses APOBEC3G/APOBEC3F; virion assembly Nef CD4/MHC downregulation; prevents apoptosis; increases efficiency of reverse transcription; T-cell activation Table 1. HIV-1 proteins analyzed in the yeast two-hybrid assays
Figure 6 个
Table 1 个
