-
Akhmetzyanova I, Zelinskyy G, Schimmer S, Brandau S, Altenhoff P, Sparwasser T, Dittmer U, 2013: Tumor-specific cd4+ t cells develop cytotoxic activity and eliminate virus-induced tumor cells in the absence of regulatory t cells[J]. Cancer Immunol Immun: CII, 62, 257-271. doi: 10.1007/s00262-012-1329-y
-
Akimova T, Beier U H, Wang L, Levine M H, Hancock W W, 2011: Helios expression is a marker of t cell activation and proliferation[J]. PloS One, 6, e24226-.
-
Alatrakchi N, Koziel M, 2009: Regulatory t cells and viral liver disease[J]. J Viral Hepatitis, 16, 223-229. doi: 10.1111/j.1365-2893.2009.01081.x
-
Antunes I, Tolaini M, Kissenpfennig A, Iwashiro M, Kuribayashi K, Malissen B, Hasenkrug K, Kassiotis G, 2008: Retrovirus-specificity of regulatory t cells is neither present nor required in preventing retrovirus-induced bone marrow immune pathology[J]. Immunity, 29, 782-794. doi: 10.1016/j.immuni.2008.09.016
-
Barber D L, Wherry E J, Masopust D, Zhu B, Allison J P, Sharpe A H, Freeman G J, Ahmed R, 2006: Restoring function in exhausted cd8 t cells during chronic viral infection[J]. Nature, 439, 682-687. doi: 10.1038/nature04444
-
Barron L, Dooms H, Hoyer K K, Kuswanto W, Hofmann J, O'Gorman W E, Abbas A K, 2010: Cutting edgeh: Mechanisms of il-2-dependent maintenance of functional regulatory t cells[J]. J Immunol, 185, 6426-6430. doi: 10.4049/jimmunol.0903940
-
Bedoya F, Cheng G S, Leibow A, Zakhary N, Weissler K, Garcia V, Aitken M, Kropf E, Garlick D S, Wherry E J, Erikson J, Caton A J, 2013: Viral antigen induces differentiation of foxp3+ natural regulatory t cells in influenza virus-infected mice[J]. J Immunol, 190, 6115-6125. doi: 10.4049/jimmunol.1203302
-
Blackburn S D, Shin H, Haining W N, Zou T, Workman C J, Polley A, Betts M R, Freeman G J, Vignali D A, Wherry E J, 2009: Coregulation of cd8+ t cell exhaustion by multiple inhibitory receptors during chronic viral infection[J]. Nat Immunol, 10, 29-37. doi: 10.1038/ni.1679
-
Cabarrocas J, Cassan C, Magnusson F, Piaggio E, Mars L, Derbinski J, Kyewski B, Gross D A, Salomon B L, Khazaie K, Saoudi A, Liblau R S, 2006: Foxp3+ cd25+ regulatory t cells specific for a neo-self-antigen develop at the double-positive thymic stage[J]. P Nat Acad Sci USA, 103, 8453-8458. doi: 10.1073/pnas.0603086103
-
Chevalier M F, Weiss L, 2013: The split personality of regulatory t cells in hiv infection[J]. Blood, 121, 29-37. doi: 10.1182/blood-2012-07-409755
-
Choi Y, Kappler J W, Marrack P, 1991: A superantigen encoded in the open reading frame of the 3' long terminal repeat of mouse mammary tumour virus[J]. Nature, 350, 203-207. doi: 10.1038/350203a0
-
Coquet J M, Ribot J C, Babala N, Middendorp S, van der Horst G, Xiao Y, Neves J F, Fonseca-Pereira D, Jacobs H, Pennington D J, Silva-Santos B, Borst J, 2013: Epithelial and dendritic cells in the thymic medulla promote cd4+foxp3+ regulatory t cell development via the cd27-cd70 pathway[J]. J Exp Med, 210, 715-728. doi: 10.1084/jem.20112061
-
Coutinho A, Caramalho I, Seixas E, Demengeot J, 2005: Thymic commitment of regulatory t cells is a pathway of tcr-dependent selection that isolates repertoires undergoing positive or negative selection[J]. Curr Top Microbiol, 293, 43-71.
-
Dietze K K, Zelinskyy G, Liu J, Kretzmer F, Schimmer S, Dittmer U, 2013: Combining regulatory t cell depletion and inhibitory receptor blockade improves reactivation of exhausted virus-specific cd8(+) t cells and efficiently reduces chronic retroviral loads[J]. PLoS Pathog, 9, e1003798-.
-
Dittmer U, He H, Messer R J, Schimmer S, Olbrich A R, Ohlen C, Greenberg P D, Stromnes I M, Iwashiro M, Sakaguchi S, Evans L H, Peterson K E, Yang G, Hasenkrug K J, 2004: Functional impairment of cd8 (+) t cells by regulatory t cells during persistent retroviral infection[J]. Immunity, 20, 293-303. doi: 10.1016/S1074-7613(04)00054-8
-
Ebinuma H, Nakamoto N, Li Y, Price D A, Gostick E, Levine B L, Tobias J, Kwok W W, Chang K M, 2008: Identification and in vitro expansion of functional antigen-specific cd25+ foxp3+ regulatory t cells in hepatitis c virus infection[J]. J Virol, 82, 5043-5053. doi: 10.1128/JVI.01548-07
-
Fontenot J D, Rasmussen J P, Williams L M, Dooley J L, Farr A G, Rudensky A Y, 2005: Regulatory t cell lineage specification by the forkhead transcription factor foxp3[J]. Immunity, 22, 329-341. doi: 10.1016/j.immuni.2005.01.016
-
Francisco L M, Salinas V H, Brown K E, Vanguri V K, Freeman G J, Kuchroo V K, Sharpe A H, 2009: Pd-l1 regulates the development, maintenance, and function of induced regulatory t cells[J]. J Exp Med, 206, 3015-3029. doi: 10.1084/jem.20090847
-
Furuichi Y, Tokuyama H, Ueha S, Kurachi M, Moriyasu F, Kakimi K, 2005: Depletion of cd25+cd4+t cells (tregs) enhances the hbv-specific cd8+ t cell response primed by DNA immunization[J]. World J Gastroentero, 11, 3772-3777. doi: 10.3748/wjg.v11.i24.3772
-
Gottschalk R A, Corse E, Allison J P, 2012: Expression of helios in peripherally induced foxp3+ regulatory t cells[J]. J Immunol, 188, 976-980. doi: 10.4049/jimmunol.1102964
-
Iwashiro M, Messer R J, Peterson K E, Stromnes I M, Sugie T, Hasenkrug K J, 2001: Immunosuppression by cd4+ regulatory t cells induced by chronic retroviral infection[J]. P Nat Acad Sci USA, 98, 9226-9230. doi: 10.1073/pnas.151174198
-
Jones R B, Ndhlovu L C, Barbour J D, Sheth P M, Jha A R, Long B R, Wong J C, Satkunarajah M, Schweneker M, Chapman J M, Gyenes G, Vali B, Hyrcza M D, Yue F Y, Kovacs C, Sassi A, Loutfy M, Halpenny R, Persad D, Spotts G, Hecht F M, Chun T W, McCune J M, Kaul R, Rini J M, Nixon D F, Ostrowski M A, 2008: Tim-3 expression defines a novel population of dysfunctional t cells with highly elevated frequencies in progressive hiv-1 infection[J]. J Exp Med, 205, 2763-2779. doi: 10.1084/jem.20081398
-
Killebrew J R, Perdue N, Kwan A, Thornton A M, Shevach E M, Campbell D J, 2011: A self-reactive tcr drives the development of foxp3+ regulatory t cells that prevent autoimmune disease[J]. J Immunol, 187, 861-869. doi: 10.4049/jimmunol.1004009
-
Kohm A P, Carpentier P A, Anger H A, Miller S D, 2002: Cutting edge: Cd4+cd25+ regulatory t cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis[J]. J Immunol, 169, 4712-4716. doi: 10.4049/jimmunol.169.9.4712
-
Kryworuchko M, Theze J, 2006: Interleukin-2: From t cell growth and homeostasis to immune reconstitution of hiv patients[J]. Vitam Horm, 74, 531-547. doi: 10.1016/S0083-6729(06)74021-3
-
Leavy O, 2013: Regulatory t cells: The thymic medulla -a cradle for treg cell development[J]. Nat Rev Immunol, 13, 304-.
-
Li W, Green W R, 2011: Immunotherapy of murine retrovirus-induced acquired immunodeficiency by cd4 t regulatory cell depletion and pd-1 blockade[J]. J Virol, 85, 13342-13353. doi: 10.1128/JVI.00120-11
-
Lilly F, Steeves R A, 1973: B-tropic friend virus: A host-range pseudotype of spleen focus-forming virus (sffv)[J]. Virology, 55, 363-370. doi: 10.1016/0042-6822(73)90176-1
-
Malek T R, 2003: The main function of il-2 is to promote the development of t regulatory cells[J]. J Leukocyte Biol, 74, 961-965. doi: 10.1189/jlb.0603272
-
Manigold T, Racanelli V, 2007: T-cell regulation by cd4 regulatory t cells during hepatitis b and c virus infections: Facts and controversies[J]. Lancet Infect Dis, 7, 804-813. doi: 10.1016/S1473-3099(07)70289-X
-
Mills K H, 2004: Regulatory t cells: Friend or foe in immunity to infection?[J]. Nat Rev Immunol, 4, 841-855.
-
Myers L, Joedicke J J, Carmody A B, Messer R J, Kassiotis G, Dudley J P, Dittmer U, Hasenkrug K J, 2013: Il-2-independent and tnf-alpha-dependent expansion of vbeta5+ natural regulatory t cells during retrovirus infection[J]. J Immunol, 190, 5485-5495. doi: 10.4049/jimmunol.1202951
-
Nilsson J, Boasso A, Velilla P A, Zhang R, Vaccari M, Franchini G, Shearer G M, Andersson J, Chougnet C, 2006: Hiv-1-driven regulatory t-cell accumulation in lymphoid tissues is associated with disease progression in hiv/aids[J]. Blood, 108, 3808-3817. doi: 10.1182/blood-2006-05-021576
-
Palmer B E, Neff C P, Lecureux J, Ehler A, Dsouza M, Remling-Mulder L, Korman A J, Fontenot A P, Akkina R, 2013: In vivo blockade of the pd-1 receptor suppresses hiv-1 viral loads and improves cd4+ t cell levels in humanized mice[J]. J Immunol, 190, 211-219. doi: 10.4049/jimmunol.1201108
-
Piersma S J, van der Hulst J M, Kwappenberg K M, Goedemans R, van der Minne C E, van der Burg S H, 2010: Influenza matrix 1-specific human cd4+ foxp3+ and foxp3 (-) regulatory t cells can be detected long after viral clearance[J]. Eur J Immunol, 40, 3064-3074. doi: 10.1002/eji.200940177
-
Presicce P, Orsborn K, King E, Pratt J, Fichtenbaum C J, Chougnet C A, 2011: Frequency of circulating regulatory t cells increases during chronic hiv infection and is largely controlled by highly active antiretroviral therapy[J]. PloS One, 6, e28118-.
-
Punkosdy G A, Blain M, Glass D D, Lozano M M, O'Mara L, Dudley J P, Ahmed R, Shevach E M, 2011: Regulatory t-cell expansion during chronic viral infection is dependent on endogenous retroviral superantigens[J]. P Nat Acad Sci USA, 108, 3677-3682. doi: 10.1073/pnas.1100213108
-
Robertson S J, Messer R J, Carmody A B, Hasenkrug K J, 2006: In vitro suppression of cd8+ t cell function by friend virus-induced regulatory t cells[J]. J Immunol, 176, 3342-3349. doi: 10.4049/jimmunol.176.6.3342
-
Sadlack B, Merz H, Schorle H, Schimpl A, Feller A C, Horak I, 1993: Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene[J]. Cell, 75, 253-261. doi: 10.1016/0092-8674(93)80067-O
-
Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M, 1995: Immunologic self-tolerance maintained by activated t cells expressing il-2 receptor alpha-chains (cd25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.[J]. J Immunol, 155, 1151-1164.
-
Sakuishi K, Ngiow S F, Sullivan J M, Teng M W, Kuchroo V K, Smyth M J, Anderson A C, 2013: Tim3foxp3 regulatory t cells are tissue-specific promoters of t-cell dysfunction in cancer[J]. Oncoimmunology, 2, e23849-.
-
Sanchez A M, Zhu J, Huang X, Yang Y, 2012: The development and function of memory regulatory t cells after acute viral infections[J]. J Immunol, 189, 2805-2814. doi: 10.4049/jimmunol.1200645
-
Scheffold A, Huhn J, Hofer T, 2005: Regulation of cd4+cd25+ regulatory t cell activity: It takes (il-) two to tango[J]. Eur J Immunol, 35, 1336-1341. doi: 10.1002/eji.200425887
-
Sugimoto N, Oida T, Hirota K, Nakamura K, Nomura T, Uchiyama T, Sakaguchi S, 2006: Foxp3-dependent and -independent molecules specific for cd25+cd4+ natural regulatory t cells revealed by DNA microarray analysis[J]. Int Immunol, 18, 1197-1209. doi: 10.1093/intimm/dxl060
-
Suzuki H, Duncan G S, Takimoto H, Mak T W, 1997: Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the il-2 receptor beta chain[J]. J Exp Med, 185, 499-505. doi: 10.1084/jem.185.3.499
-
Taylor A L, Llewelyn M J, 2010: Superantigen-induced proliferation of human cd4+cd25-t cells is followed by a switch to a functional regulatory phenotype[J]. J Immunol, 185, 6591-6598. doi: 10.4049/jimmunol.1002416
-
Thornton A M, Korty P E, Tran D Q, Wohlfert E A, Murray P E, Belkaid Y, Shevach E M, 2010: Expression of helios, an ikaros transcription factor family member, differentiates thymic-derived from peripherally induced foxp3+ t regulatory cells[J]. J Immunol, 184, 3433-3441. doi: 10.4049/jimmunol.0904028
-
Verhagen J, Wraith D C. 2010. Comment on "expression of helios, an ikaros transcription factor family member, differentiates thymic-derived from peripherally induced foxp3+ t regulatory cells". J Immunol, 185: 7129; author reply 7130.
-
Wang H Y, Lee D A, Peng G, Guo Z, Li Y, Kiniwa Y, Shevach E M, Wang R F, 2004: Tumor-specific human cd4+ regulatory t cells and their ligands: Implications for immunotherapy[J]. Immunity, 20, 107-118. doi: 10.1016/S1074-7613(03)00359-5
-
Wei W Z, Morris G P, Kong Y C, 2004: Anti-tumor immunity and autoimmunity: A balancing act of regulatory t cells[J]. Cancer Immunol Immun, 53, 73-78. doi: 10.1007/s00262-003-0444-1
-
Willerford D M, Chen J, Ferry J A, Davidson L, Ma A, Alt F W, 1995: Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment[J]. Immunity, 3, 521-530. doi: 10.1016/1074-7613(95)90180-9
-
Woodland D, Happ M P, Bill J, Palmer E, 1990: Requirement for cotolerogenic gene products in the clonal deletion of i-e reactive t cells[J]. Science, 247, 964-967. doi: 10.1126/science.1968289
-
Woodland D L, Blackman M A, 1993: How do t-cell receptors, mhc molecules and superantigens get together?[J]. Immunology Today, 14, 208-212.
-
Yang J H, Zhang Y X, Yu R B, Su C, Sun N X, 2006: cd4+ cd25+ regulatory t cells suppress cd4+ t cell responses in patients with persistent hepatitis c virus infection[J]. Chinese Journal of Internal Medicine, 45, 29-33. doi: 10.2169/internalmedicine.45.1467
-
Young G R, Ploquin M J, Eksmond U, Wadwa M, Stoye J P, Kassiotis G, 2012: Negative selection by an endogenous retrovirus promotes a higher-avidity cd4+ t cell response to retroviral infection[J]. PLoS Pathog, 8, e1002709-.
-
Zelinskyy G, Kraft A R, Schimmer S, Arndt T, Dittmer U, 2006: Kinetics of cd8+ effector t cell responses and induced cd4+ regulatory t cell responses during friend retrovirus infection[J]. Eur J Immunol, 36, 2658-2670. doi: 10.1002/eji.200636059
-
Zelinskyy G, Dietze K K, Husecken Y P, Schimmer S, Nair S, Werner T, Gibbert K, Kershaw O, Gruber A D, Sparwasser T, Dittmer U, 2009: The regulatory t-cell response during acute retroviral infection is locally defined and controls the magnitude and duration of the virus-specific cytotoxic t-cell response[J]. Blood, 114, 3199-3207. doi: 10.1182/blood-2009-03-208736
-
Zhou Q, Munger M E, Highfill S L, Tolar J, Weigel B J, Riddle M, Sharpe A H, Vallera D A, Azuma M, Levine B L, June C H, Murphy W J, Munn D H, Blazar B R, 2010: Program death-1 signaling and regulatory t cells collaborate to resist the function of adoptively transferred cytotoxic t lymphocytes in advanced acute myeloid leukemia[J]. Blood, 116, 2484-2493. doi: 10.1182/blood-2010-03-275446