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Protein Function Reference CD300a Interacts with the PtdEth on the surface of DENV particles and promotes viral internalization Carnec et al., 2015 RNASEK Plays a role in viral endocytosis Perreira et al., 2015 OST Plays a role in viral RNA replication by interacting with viral proteins Marceau et al., 2016 hnRNP K Promotes viral multiplication Brunetti et al., 2015 SPCS Promotes the processing of structural proteins Zhang et al., 2016 CCR5 Facilitates viral infection Marques et al., 2015 Receptor-activated α2M (α2M*) Promotes viral stability and improves viral infectivity Huerta et al., 2014 GBF1 Facilitates viral C protein transportation Iglesias et al., 2015 PEX19 Signaling platform for innate immunity You et al., 2015 HO-1 Inhibits viral NS2B/NS3 protease activity Tseng et al., 2016 TRIM56 Inhibits viral RNA replication Liu et al., 2014 GRP75 Promotes mature processing of the antiviral miRNA hsa-mir-126 Kakumani et al., 2016 eIF4AI Inhibits viral protein synthesis Chen et al., 2015 DDX3 Promotes IFN response Li et al., 2015 Table 1. Host proteins and DENV
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miRNA Function Reference miR-146a Reduces IFN-β production by targeting TRAF6 Wu et al., 2013 miR-281 Increases DENV2 replication by targeting 5′-UTR of viral genome Zhou et al., 2014 Receptor-activated miR-30e (miR-30e*) Represses DENV2 replication by targeting Iκ-Bα and promoting IFN-β production Zhu et al., 2014 Let-7c Decreases viral replication by targeting BACH1 Escalera-Cueto et al., 2015 miR-223 Decreases viral replication by targeting STMN1 Wu et al., 2014 miR-133a Decreases viral replication by targeting proviral PTB Castillo et al., 2016 Table 2. Host miRNAs and DENV
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