Figure 4个  Table 1
    • Name Vaccine
      type
      Antigen Experimental
      model
      Immune
      response induced
      Stage Reference
      Formalin-
      inactivated CHIKV
      Inactivated Whole virus Human N/A Phase I N/A
      TSI-GSD-218 Live-attenuated Whole virus Human Humoral Phase II Edelman et al., 2000
      VRC-CHKVLP
      059-OO-VP
      VLP C-E2-E1 Human Humoral Phase II Chang et al., 2014
      MV-CHIK Chimeric C-E3-E2-6K-E1 Human Humoral Phase II Ramsauer et al., 2015
      LR2006-
      OPYI-modified
      DNA Δ5nsP3;Δ6K Mice Humoral & cellular Preclinical Hallengard et al., 2014
      CHIK-E1/E2 Subunit E1, E2 Mice Humoral & cellular Preclinical Khan et al., 2012
      Note: Δ stands for nucleotide sequence deletion; N/A: not available.

      Table 1.  Major CHIKV vaccine candidates in clinical and preclinical studies*