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Name Vaccine
typeAntigen Experimental
modelImmune
response inducedStage Reference Formalin-
inactivated CHIKVInactivated Whole virus Human N/A Phase I N/A TSI-GSD-218 Live-attenuated Whole virus Human Humoral Phase II Edelman et al., 2000 VRC-CHKVLP
059-OO-VPVLP C-E2-E1 Human Humoral Phase II Chang et al., 2014 MV-CHIK Chimeric C-E3-E2-6K-E1 Human Humoral Phase II Ramsauer et al., 2015 LR2006-
OPYI-modifiedDNA Δ5nsP3;Δ6K Mice Humoral & cellular Preclinical Hallengard et al., 2014 CHIK-E1/E2 Subunit E1, E2 Mice Humoral & cellular Preclinical Khan et al., 2012 Note: Δ stands for nucleotide sequence deletion; N/A: not available. Table 1. Major CHIKV vaccine candidates in clinical and preclinical studies*
Figure 4 个
Table 1 个