Figure 9个  Table 1
    • VirusesaCollection dateHA(H3 numbering)PB2NAM2PB1-F2
      Connecting peptide110158160224-228318519627701274bStalk deletion273158-90 truncated
      A/tiger/Jiangsu/01/20132013.1.20RERRRKRGHDANGQSGTQEDH49–68ISYes
      A/Alberta/01/20142014.1.3RERRRKRGHDANRQSGTQEDH49–68ISYes
      A/Stone_curlew/Dubai/AR3444-25042/20142014.11.17RERRRKRGHDANGQSGTQEDH49–68ISYes
      A/Quail/Dubai/AR3445-25043/20142014.11.30RERRRKRGHDANGQSGTQEDH49–68ISYes
      A/Sea_Gull/Dubai/AR3443-25041/20142014.12.1RERRRKRGHDANGQSGTQEDH49–68ISYes
      A/Duck/Dubai/2459/20142014.12.7RERRRKRGHDANGQSGTQEDH49–68ISYes
      A/Falcon/Dubai/2506/20142014.12.7RERRRKRGHDANGQSGTQEDH49–68ISYes
      A/Falcon/Dubai/AR3430-2293/20142014.12.7RERRRKRGHDANGQSGTQEDH49–68ISYes
      A/Hoabara/Dubai/2455.5/20142014.12.7RERRRKRGHDANGQSGTQEDH49–68ISYes
      A/chicken/Ghana/15VIR2588-9/20152015(NO DATE)RERRRKRGHDANGQSGT
      A/chicken/Ghana/FJ152511/20152015(NO DATE)RERRRKRGHGANGQSGTH49–68
      A/chicken/Nigeria/15VIR339-2/20152015.1RERRRKRGHXANGQSGTQEDH49–68ISNo
      A/chicken/Niger/15VIR2060-6/20152015.4.4RERRRKRGHDANGQSGT
      A/chicken/Burkina_Faso/15VIR1774-35/20152015.3.23RERRRKRGHDANGQSGT
      A/duck/Ivory_Coast/15VIR-2742-1/20152015.4.13RERRRKRGHDANGQSGT
      A/enviroment/Henan/SMX1/20152015.1.5RERRRKRGHDANGQSGTQEDH49–68ISYes
      A/whooper_swan/Henan/SMX1/20152015.1.4RERRRKRGHDANGQSGTQEDH49–68ISYes
      A/whooper_swan/Henan/SMX3/20152015.1.5RERRRKRGHDANGQSGTQEDH49–68ISYes
      A/whooper swan/Henan/SMX4/20152015.1.4RERRRKRGHDANGQSGTQEDH49–68ISYes
      A/whooper_swan/Henan/SMX9/20152015.1.5RERRRKRGHDANGQSGTQEDH49–68ISYes
      A/pochard/Henan/SMX1/20152015.1.5RERRRKRGHDANGQSGTQEDH49–68ISYes
      A/dalmatian_pelican/Bulgaria/3/20152015.1.23RERRRKRGHNANGQSGT
      A/dalmatian_pelican/Bulgaria/4/20152015.1.23RERRRKRGHNANGQSGT
      A/chicken/Bulgaria/5407/152015.1.30RERRRKRGHNANGQSGT
      A/chicken/Bulgaria/5408/152015.1.30RERRRKRGHNANGQSGT
      A/chicken/Bulgaria/5409/152015.1.30RERRRKRGHNANGQSGT
      A/pelican/Romania/12449/20152015.3.26RERRRKRGHNANGQSGT
      A/rook/Chany/32/20152015.5.7RERRRKRGHDANGQSGTQEDH49–68ISYes
      A/rook/Dovolnoe/50/20152015.5.7RERRRKRGHDANGQSGTQEDH49–68ISYes
      A/rook/Sartlan/42/20152015.5.7RERRRKRGHDANGQSGTQEDH49–68ISYes
      A/Black-necked Grebe/Inner Mongolia/Brain1/20152015.5.12RERRRKRGHDANGQSGTQEDH49–68ISYes
      A/Black-necked Grebe/Inner Mongolia/Brain2/20152015.5.12RERRRKRGHDANGQSGTQEDH49–68ISYes
      A/Black-necked Grebe/Inner Mongolia/Lung2/20152015.5.12RERRRKRGHDANGQSGTQEDH49–68ISYes
      A/Black-necked Grebe/Inner Mongolia/Brain3/20152015.5.12RERRRKRGHDANGQSGTQEDH49–68ISYes
      A/Black-necked Grebe/Inner Mongolia/Liver3/20152015.5.12RERRRKRGHDANGQSGTQEDH49–68ISYes
      A/Black-necked Grebe/Inner Mongolia/Lung3/20152015.5.12RERRRKRGHDANGQSGTQEDH49–68ISYes
      A/Black-necked Grebe/Inner Mongolia/Lung3-2/20152015.5.12RERRRKRGHDANGQSGTQEDH49–68ISYes
      A/Black-necked Grebe/Inner Mongolia/Oropharynx swab3/20152015.5.12RERRRKRGHDANGQSGTQEDH49–68ISYes
      A/Black-necked Grebe/Inner Mongolia/Trachea3/20152015.5.12RERRRKRGHDANGQSGTQEDH49–68ISYes
      A/Black-necked Grebe/Inner Mongolia/Anal swab4/20152015.5.12RERRRKRGHDANGQSGTQEDH49–68ISYes
      A/Bar-headed Goose/Qinghai/BTY2/20152015.7.14RERRRKRGHDANGQSGTQEDH49–68ISYes
      A/Great black-headed Gull/Qinghai/YO1/20152015.7.14RERRRKRGHDANGQSGTQEDH49–68ISYes
      A/Great black-headed Gull/Qinghai/YO6/20152015.7.14RERRRKRGHDANGQSGTQEDH49–68ISYes

      Table S1.  Comparison of key amino acid pattern of Clade 2.3.2.1c HPAI A (H5N1) viruses from different geographic regions