• Bal, J., Jung, H.Y., Nguyen, L.N., Park, J., Jang, Y.S., Kim, D.H., 2018. Evaluation of cellsurface displayed synthetic consensus dengue EDIII cells as a potent oral vaccine candidate. Microb. Cell Factories 17, 146.

  • Barban, V., Mantel, N., De Montfort, A., Pagnon, A., Pradezynski, F., Lang, J., Boudet, F., 2018. Improvement of the dengue virus (DENV) nonhuman primate model via a reverse translational approach based on dengue vaccine clinical efficacy data against DENV-2 and -4. J. Virol. 92 e00440-00418.

  • Beatty, P.R., Puerta-Guardo, H., Killingbeck, S.S., Glasner, D.R., Hopkins, K., Harris, E., 2015. Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination. Sci. Transl. Med. 7, 304ra141.

  • Bhamarapravati, N., Sutee, Y., 2000. Live attenuated tetravalent dengue vaccine. Vaccine 18, 44-47.

  • Biswal, S., Reynales, H., Saez-Llorens, X., Lopez, P., Borja-Tabora, C., Kosalaraksa, P., Sirivichayakul, C., Watanaveeradej, V., Rivera, L., Espinoza, F., Fernando, L., Dietze, R., Luz, K., Venancio Da Cunha, R., Jimeno, J., Lopez-Medina, E., Borkowski, A., Brose, M., Rauscher, M., Lefevre, I., Bizjajeva, S., Bravo, L., Wallace, D., Group, T.S., 2019. Efficacy of a tetravalent dengue vaccine in healthy children and adolescents. N. Engl. J. Med. 381, 2009-2019.

  • Capeding, R.Z., Luna, I.A., Bomasang, E., Lupisan, S., Lang, J., Forrat, R., Wartel, A., Crevat, D., 2011. Live-attenuated, tetravalent dengue vaccine in children, adolescents and adults in a dengue endemic country:randomized controlled phase I trial in the Philippines. Vaccine 29, 3863-3872.

  • Chiang, C.Y., Huang, M.H., Hsieh, C.H., Chen, M.Y., Liu, H.H., Tsai, J.P., Li, Y.S., Chang, C.Y., Liu, S.J., Chong, P., Leng, C.H., Chen, H.W., 2012. Dengue-1 envelope protein domain III along with PELC and CpG oligodeoxynucleotides synergistically enhances immune responses. PLoS Neglected Trop. Dis. 6, e1645.

  • Christofferson Rc, M.M., Johnson, Am, Chisenhall, Dm, Mores, Cn, 2013. Development of a transmission model for dengue virus. Virol. J. 10, 127.

  • Costa, S.M., Paes, M.V., Barreto, D.F., Pinhao, A.T., Barth, O.M., Queiroz, J.L., Armoa, G.R., Freire, M.S., Alves, A.M., 2006. Protection against dengue type 2 virus induced in mice immunized with a DNA plasmid encoding the non-structural 1 (NS1) gene fused to the tissue plasminogen activator signal sequence. Vaccine 24, 195-205.

  • Cui, G., Si, L., Wang, Y., Zhou, J., Yan, H., Jiang, L., 2021. Antibody-dependent enhancement (ADE) of dengue virus:identification of the key amino acid that is vital in DENV vaccine research. J. Gene Med. 23, e3297.

  • Dai, L., Xu, K., Li, J., Huang, Q., Song, J., Han, Y., Zheng, T., Gao, P., Lu, X., Yang, H., Liu, K., Xia, Q., Wang, Q., Chai, Y., Qi, J., Yan, J., Gao, G.F., 2021. Protective Zika vaccines engineered to eliminate enhancement of dengue infection via immunodominance switch. Nat. Immunol. 22, 958-968.

  • Dhanoa, A., Hassan, S.S., Ngim, C.F., Lau, C.F., Chan, T.S., Adnan, N.A., Eng, W.W., Gan, H.M., Rajasekaram, G., 2016. Impact of dengue virus (DENV) co-infection on clinical manifestations, disease severity and laboratory parameters. BMC Infect. Dis. 16, 406.

  • Durbin, A.P., Pierce, K.K., Kirkpatrick, B.D., Grier, P., Sabundayo, B.P., He, H., Sausser, M., Russell, A.F., Martin, J., Hyatt, D., Cook, M., Sachs, J.R., Lee, A.W., Wang, L., Coller, B.A., Whitehead, S.S., 2020. Immunogenicity and safety of a tetravalent recombinant subunit dengue vaccine in adults previously vaccinated with a live attenuated tetravalent dengue vaccine:results of a phase-I randomized clinical trial. Am. J. Trop. Med. Hyg. 103, 855-863.

  • Elong Ngono, A., Shresta, S., 2019. Cross-reactive T cell immunity to dengue and Zika viruses:new insights into vaccine development. Front. Immunol. 10, 1316.

  • Golden, J.W., Josleyn, M.D., Hooper, J.W., 2008. Targeting the vaccinia virus L1 protein to the cell surface enhances production of neutralizing antibodies. Vaccine 26, 3507-3515.

  • Gomes-Ruiz, A.C., Nascimento Rt Fau-De Paula, S.O., De Paula So Fau-Lopes Da Fonseca, B.A., Lopes Da Fonseca, B.A., 2006. SYBR green and TaqMan real-time PCR assays are equivalent for the diagnosis of dengue virus type 3 infections. J. Med.Virol. 78, 760-763.

  • Grifoni, A., Tian, Y., Sette, A., Weiskopf, D., 2020. Transcriptomic immune profiles of human flavivirus-specific T-cell responses. Immunology 160, 3-9.

  • Guirakhoo, F., Arroyo, J., Pugachev, K.V., Miller, C., Zhang, Z.X., Weltzin, R., Georgakopoulos, K., Catalan, J., Ocran, S., Soike, K., Ratterree, M., Monath, T.P., 2001. Construction, safety, and immunogenicity in nonhuman primates of a chimeric yellow fever-dengue virus tetravalent vaccine. J. Virol. 75, 7290-7304.

  • Guy, B., Barban V Fau-Mantel, N., Mantel N Fau-Aguirre, M., Aguirre M Fau-Gulia, S., Gulia S Fau-Pontvianne, J., Pontvianne J Fau-Jourdier, T.-M., Jourdier Tm Fau -Ramirez, L., Ramirez L Fau-Gregoire, V., Gregoire V Fau-Charnay, C., Charnay C Fau-Burdin, N., Burdin N Fau-Dumas, R., Dumas R Fau-Lang, J., Lang, J., 2009. Evaluation of interferences between dengue vaccine serotypes in a monkey model. Am. J. Trop. Med. Hyg. 80, 302-311.

  • Guzman, M.G., Hermida L Fau-Bernardo, L., Bernardo L Fau-Ramirez, R., Ramirez R Fau-Guillén, G., Guillén, G., 2010. Domain III of the envelope protein as a dengue vaccine target. Expert Rev. Vaccines 9, 137-147.

  • Jackson, L.A., Rupp, R., Papadimitriou, A., Wallace, D., Raanan, M., Moss, K.J., 2018. A phase 1 study of safety and immunogenicity following intradermal administration of a tetravalent dengue vaccine candidate. Vaccine 36, 3976-3983.

  • Jearanaiwitayakul, T., Sunintaboon, P., Chawengkittikul, R., Limthongkul, J., Midoeng, P., Warit, S., Ubol, S., 2020. Nanodelivery system enhances the immunogenicity of dengue-2 nonstructural protein 1, DENV-2 NS1. Vaccine 38, 6814-6825.

  • Katzelnick, L.C., Harris, E., Participants in the Summit on Dengue Immune Correlates Of Protection, 2017. Immune correlates of protection for dengue:state of the art and research agenda. Vaccine 35, 4659-4669.

  • Katzelnick, L.C., Montoya, M., Gresh, L., Balmaseda, A., Harris, E., 2016. Neutralizing antibody titers against dengue virus correlate with protection from symptomatic infection in a longitudinal cohort. Proc. Natl. Acad. Sci. U. S. A. 113, 728-733.

  • Khetarpal, N., Khanna, I., 2016. Dengue fever:causes, complications, and vaccine strategies. J. Immunol. Res. 2016, 1-14.

  • Kim, M.Y., Copland, A., Nayak, K., Chandele, A., Ahmed, M.S., Zhang, Q., Diogo, G.R., Paul, M.J., Hofmann, S., Yang, M.S., Jang, Y.S., Ma, J.K., Reljic, R., 2018. Plantexpressed Fc-fusion protein tetravalent dengue vaccine with inherent adjuvant properties. Plant Biotechnol. J 16, 1283-1294.

  • Kirkpatrick, B.D., Durbin, A.P., Pierce, K.K., Carmolli, M.P., Tibery, C.M., Grier, P.L., Hynes, N., Diehl, S.A., Elwood, D., Jarvis, A.P., Sabundayo, B.P., Lyon, C.E., Larsson, C.J., Jo, M., Lovchik, J.M., Luke, C.J., Walsh, M.C., Fraser, E.A., Subbarao, K., Whitehead, S.S., 2015. Robust and balanced immune responses to all 4 dengue virus serotypes following administration of a single dose of a live attenuated tetravalent dengue vaccine to healthy, flavivirus-naive adults. J. Infect. Dis. 212, 702-710.

  • Kirkpatrick, B.D., Whitehead, S.S., Pierce, K.K., Tibery, C.M., Grier, P.L., Hynes, N.A., Larsson, C.J., Sabundayo, B.P., Talaat, K.R., Janiak, A., Carmolli, M.P., Luke, C.J., Diehl, S.A., Durbin, A.P., 2016. The live attenuated dengue vaccine TV003 elicits complete protection against dengue in a human challenge model. Sci. Transl. Med. 8, 330-336.

  • Liu, Y., Zhang, Y., Wei, Y., Jia, X., Chen, Q., Liu, W., Yang, L., 2020. Development and characterization of serotype-specific monoclonal antibodies against Dengue virus NS1. Sheng Wu Gong Cheng Xue Bao 36, 2206-2215 (In Chinese).

  • Martinez, D.R., Metz, S.W., Baric, R.S., 2021. Dengue vaccines:the promise and pitfalls of antibody-mediated protection. Cell. Host Microbe. 29, 13-22.

  • Maruggi, G., Zhang, C., Li, J., Ulmer, J.B., Yu, D., 2019. mRNA as a transformative Technology for vaccine development to control infectious diseases. Mol. Ther. 27, 757-772.

  • Matangkasombut, P., Manopwisedjaroen, K., Pitabut, N., Thaloengsok, S., Suraamornkul, S., Yingtaweesak, T., Duong, V., Sakuntabhai, A., Paul, R., Singhasivanon, P., 2020. Dengue viremia kinetics in asymptomatic and symptomatic infection. Int. J. Infect. Dis. 101, 90-97.

  • Milligan, G.N., Sarathy, V.V., White, M.M., Greenberg, M.B., Campbell, G.A., Pyles, R.B., Barrett, A.D.T., Bourne, N., 2017. A lethal model of disseminated dengue virus type 1 infection in AG129 mice. J. Gen. Virol. 98, 2507-2519.

  • Mishra, B., Turuk, J., Sahu, S.J., Khajuria, A., Kumar, S., Dey, A., Praharaj, A.K., 2017. Cocirculation of all four dengue virus serotypes:first report from Odisha. Indian J. Med. Microbiol. 35, 293-295.

  • Modhiran, N., Watterson, D., Muller, D.A., Panetta, A.K., Sester, D.P., Liu, L., Hume, D.A., Stacey, K.J., Young, P.R., 2015. Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity. Sci. Transl. Med. 7, 304ra142.

  • Nivarthi, U.K., Swanstrom, J., Delacruz, M.J., Patel, B., Durbin, A.P., Whitehead, S.S., Kirkpatrick, B.D., Pierce, K.K., Diehl, S.A., Katzelnick, L., Baric, R.S., De Silva, A.M., 2021. A tetravalent live attenuated dengue virus vaccine stimulates balanced immunity to multiple serotypes in humans. Nat. Commun. 12, 1102.

  • Oberli, M.A., Reichmuth, A.M., Dorkin, J.R., Mitchell, M.J., Fenton, O.S., Jaklenec, A., Anderson, D.G., Langer, R., Blankschtein, D., 2017. Lipid nanoparticle assisted mRNA delivery for potent cancer immunotherapy. Nano Lett. 17, 1326-1335.

  • Okimoto, T., Friedmann, T., Miyanohara, A., 2001. VSV-G envelope glycoprotein forms complexes with plasmid DNA and MLV retrovirus-like particles in cell-free conditions and enhances DNA transfection. Mol. Ther. 4, 232-238.

  • Pardi, N., Hogan, M.J., Pelc, R.S., Muramatsu, H., Andersen, H., Demaso, C.R., Dowd, K.A., Sutherland, L.L., Scearce, R.M., Parks, R., Wagner, W., Granados, A., Greenhouse, J., Walker, M., Willis, E., Yu, J.S., Mcgee, C.E., Sempowski, G.D., Mui, B.L., Tam, Y.K., Huang, Y.J., Vanlandingham, D., Holmes, V.M., Balachandran, H., Sahu, S., Lifton, M., Higgs, S., Hensley, S.E., Madden, T.D., Hope, M.J., Kariko, K., Santra, S., Graham, B.S., Lewis, M.G., Pierson, T.C., Haynes, B.F., Weissman, D., 2017. Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination. Nature 543, 248-251.

  • Paudel, D., Jarman, R., Limkittikul, K., Klungthong, C., Chamnanchanunt, S., Nisalak, A., Gibbons, R., Chokejindachai, W., 2011. Comparison of real-time SYBR green dengue assay with real-time taqman RT-PCR dengue assay and the conventional nested PCR for diagnosis of primary and secondary dengue infection. N. Am. J. Med. Sci. 3, 478-485.

  • Plummer, E., Shresta, S., 2014. Animal models in dengue. Methods Mol. Biol. 1138, 377-390.

  • Pokidysheva, E., Zhang, Y., Battisti, A.J., Bator-Kelly, C.M., Chipman, P.R., Xiao, C., Gregorio, G.G., Hendrickson, W.A., Kuhn, R.J., Rossmann, M.G., 2006. Cryo-EM reconstruction of dengue virus in complex with the carbohydrate recognition domain of DC-SIGN. Cell 124, 485-493.

  • Rai, P., Kille, S., Kotian, A., Kumar, B.K., Deekshit, V.K., Ramakrishna, M.S., Karunasagar, I., Karunasagar, I., 2021. Molecular investigation of the dengue outbreak in Karnataka, South India, reveals co-circulation of all four dengue virus serotypes. Infect. Genet. Evol. 92, 104880.

  • Ranieri, E., Popescu, I., Gigante, M., 2014. CTL ELISPOT assay. In:RANIERI, E. (Ed.), Cytotoxic T-Cells:Methods and Protocols. Springer New York, New York, NY.

  • Reddy, P.B., Pattnaik P Fau-Tripathi, N.K., Tripathi Nk Fau-Srivastava, A., Srivastava a Fau-Rao, P.V.L., Rao, P.V., 2012. Expression, purification and evaluation of diagnostic potential and immunogenicity of dengue virus type 3 domain III protein. Protein Pept. Lett. 19, 509-519.

  • Richner, J.M., Himansu, S., Dowd, K.A., Butler, S.L., Salazar, V., Fox, J.M., Julander, J.G., Tang, W.W., Shresta, S., Pierson, T.C., Ciaramella, G., Diamond, M.S., 2017a. Modified mRNA vaccines protect against Zika virus infection. Cell 168, 1114-1125 e1110.

  • Richner, J.M., Jagger, B.W., Shan, C., Fontes, C.R., Dowd, K.A., Cao, B., Himansu, S., Caine, E.A., Nunes, B.T.D., Medeiros, D.B.A., Muruato, A.E., Foreman, B.M., Luo, H., Wang, T., Barrett, A.D., Weaver, S.C., Vasconcelos, P.F.C., Rossi, S.L., Ciaramella, G., Mysorekar, I.U., Pierson, T.C., Shi, P.Y., Diamond, M.S., 2017b. Vaccine mediated protection against Zika virus-induced congenital disease. Cell 170, 273-283 e212.

  • Roth, C., Cantaert, T., Colas, C., Prot, M., Casademont, I., Levillayer, L., Thalmensi, J., Langlade-Demoyen, P., Gerke, C., Bahl, K., Ciaramella, G., Simon-Loriere, E., Sakuntabhai, A., 2019. A modified mRNA vaccine targeting immunodominant NS epitopes protects against dengue virus infection in HLA class I transgenic mice. Front. Immunol. 10, 1424.

  • Sabchareon, A., Wallace, D., Sirivichayakul, C., Limkittikul, K., Chanthavanich, P., Suvannadabba, S., Jiwariyavej, V., Dulyachai, W., Pengsaa, K., Wartel, T.A., Moureau, A., Saville, M., Bouckenooghe, A., Viviani, S., Tornieporth, N.G., Lang, J., 2012. Protective efficacy of the recombinant, live-attenuated, CYD tetravalent dengue vaccine in Thai schoolchildren:a randomised, controlled phase 2b trial. Lancet 380, 1559-1567.

  • Sáez-Llorens, X., Tricou, V., Yu, D., Rivera, L., Jimeno, J., Villarreal, A.C., Dato, E., Mazara, S., Vargas, M., Brose, M., Rauscher, M., Tuboi, S., Borkowski, A., Wallace, D., 2018. Immunogenicity and safety of one versus two doses of tetravalent dengue vaccine in healthy children aged 2-17 years in Asia and Latin America:18-month interim data from a phase 2, randomised, placebo-controlled study. Lancet Infect. Dis. 18, 162-170.

  • Sarathy, V.V., Milligan, G.N., Bourne, N., Barrett, A.D., 2015. Mouse models of dengue virus infection for vaccine testing. Vaccine 33, 7051-7060.

  • Shi, B., Xue, M., Wang, Y., Wang, Y., Li, D., Zhao, X., Li, X., 2018. An improved method for increasing the efficiency of gene transfection and transduction. Int. J. Physiol. Pathophysiol. Pharmacol. 10, 95-104.

  • Sirivichayakul, C., Barranco-Santana, E.A., Esquilin-Rivera, I., Oh, H.M., Raanan, M., Sariol, C.A., Shek, L.P., Simasathien, S., Smith, M.K., Velez, I.D., Wallace, D., Gordon, G.S., Stinchcomb, D.T., 2016. Safety and immunogenicity of a tetravalent dengue vaccine candidate in healthy children and adults in dengue-endemic regions:a randomized, placebo-controlled phase 2 study. J. Infect. Dis. 213, 1562-1572.

  • Thomas, A., Thiono, D.J., Kudlacek, S.T., Forsberg, J., Premkumar, L., Tian, S., Kuhlman, B., De Silva, A.M., Metz, S.W., 2020. Dimerization of dengue virus E subunits impacts antibody function and domain focus. J. Virol. 94, e00745-00720.

  • Vanblargan, L.A., Himansu, S., Foreman, B.M., Ebel, G.D., Pierson, T.C., Diamond, M.S., 2018. An mRNA vaccine protects mice against multiple tick-transmitted flavivirus infections. Cell Rep. 25, 3382-3392. e3383.

  • Wollner, C.J., Richner, J.M., 2021. mRNA vaccines against flaviviruses. Vaccines 9, 1464.

  • Wollner, C.J., Richner, M., Hassert, M.A., Pinto, A.K., Brien, J.D., Richner, J.M., 2021. A dengue virus serotype 1 mRNA-LNP vaccine elicits protective immune responses. J. Virol. 95, e02482-20

  • Yanez Arteta, M., Kjellman, T., Bartesaghi, S., Wallin, S., Wu, X., Kvist, A.J., Dabkowska, A., Szekely, N., Radulescu, A., Bergenholtz, J., Lindfors, L., 2018.Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles. Proc. Natl. Acad. Sci. U. S. A. 115, E3351-E3360.

  • Zhang, M., Sun, J., Li, M., Jin, X., 2020. Modified mRNA-LNP vaccines confer protection against experimental DENV-2 infection in mice. Mol. Ther. Methods Clin. Dev. 18, 702-712.

  • Zuest, R., Valdes, I., Skibinski, D., Lin, Y., Toh, Y.X., Chan, K., Hermida, L., Connolly, J., Guillen, G., Fink, K., 2015. Tetravalent dengue DIIIC protein together with alum and ODN elicits a Th1 response and neutralizing antibodies in mice. Vaccine 33, 1474-1482.