Figure 5个  Table 3个
    • Authors Year Continent(Country) Testing Method KSHV positivity (No. of positive sera/No. of tested sera)
      Total HIV-positive HIV-negative
      Khajedaluee et al. 2016 Asia (Iran) ELISA 8/111 – –
      Kakavand-Ghalehnoei et al. 2016 Asia (Iran) PCR 8/60 – –
      Lee et al. 2014 Asia (China) ELISA 27/553 25/377 2/176
      Zhang et al. 2014 Asia (China) IFA 56/296 – –
      Zavitsanou et al. 2010 Europe (Greece) ELISA 70/288 – 67/286
      Yang et al. 2010 Asia (China) ELISA 58/203 – –
      Larocca et al. 2005 Europe (Italy) IFA 14/134 8/32 6/102
      Bernstein et al. 2003 America (US) IFA 45/390 38/294 7/96
      Atkinson et al. 2003 America (US) ELISA 218/1905 55/233 163/1672
      Goedert et al. 2003 America (US) ELISA 14/137 14/137 –
      Parisi et al. 2002 Europe (Italy) IFA 13/155 13/155 –
      2002 Europe (Italy) IFA 18/85 18/85 –
      Sosa et al. 2001 America (Argentina) IFA 26/153 25/144 1/9
      Greenblatt et al. 2001 America (US) IFA 40/237 35/178 5/59
      Gambus et al. 2001 Europe (Spain) IFA 44/382 29/254 15/128
      Cannon et al. 2001 America (US) ELISA 141/771 – –
      Diamond et al. 2001 America (US) IFA 9/65 – –
      Perna et al. 2000 Europe (Italy) IFA 62/374 32/163 30/211
      Wang et al. 2000 Asia (China) ELISA 63/107 – –
      Rezza et al. 1999 Europe (Italy) IFA 20/133 20/133 –
      Renwick et al. 1998 Europe (The Netherlands) ELISA 89/1167 26/351 63/816
      Rezza et al. 1998 Europe (Italy) IFA 55/112 26/47 29/65
      Simpson et al. 1996 Europe (UK) ELISA 2/63 2/38 0/25

      Table 1.  The detailed characteristics of all eligible studies

    • Standard error Z value P value Regression coefficient (95%CI)
      Constant 73.62 1.55 0.12 113.88 (–30.40, 258.17)
      Year 0.04 –1.58 0.12 –0.06 (–0.13, 0.01)
      Continent
      America (reference) – – – –
      Asia 0.51 1.57 0.12 0.79 (–0.20, 1.79)
      Europe 0.33 –0.12 0.91 –0.04 (–0.68, 0.60)
      Testing method
      ELISA (reference) – – – –
      IFA 0.31 0.82 0.41 0.25 (–0.35, 0.86)
      PCR 0.79 0.16 0.88 0.12 (–1.43, 1.67)

      Table 2.  Meta-regression analysis showing influence of variables on the heterogeneity of prevalence (N = 7881)

    • Database Search strategy Results
      PubMed (prevalen* OR inciden* OR epidemiolog* OR seroprevalen* OR sero-prevalen* OR seroepidemiolog* OR sero-epidemiolog* OR seropositiv* OR sero-positiv* OR seroepidemiologic studies[MeSH] OR prevalence[MeSH] OR incidence[MeSH]) AND (("Drug Users"[Mesh] AND ("Injections, Intravenous"[Mesh] OR "Substance Abuse, Intravenous"[Mesh])) OR ((intraven* OR inject*) AND drug)) AND (("HHV-8" OR "HHV 8" OR "KSHV" OR "Human Herpesvirus 8" OR "Kaposi's Sarcoma-Associated Herpesvirus" OR "Kaposi's Sarcoma Associated Herpesvirus" OR "Kaposis Sarcoma-Associated Herpesvirus" OR "Kaposi Sarcoma-Associated Herpesvirus" OR "Kaposi Sarcoma Associated Herpesvirus") OR "Herpesvirus 8, Human"[Mesh]) 39
      EMBASE 1. exp Human herpesvirus 8/ 2. ("human herpesvirus 8" or "hhv-8" or "hhv8" or "kshv" or "kaposi sarcoma associated herpesvirus" or "kaposi’s sarcoma associated herpesvirus" or "kaposi sarcoma-associated herpesvirus" or "kaposi’s sarcoma-associated herpesvirus" or "kaposi NEAR/3 herpesvirus" or "kaposi NEAR/3 virus").mp. [mp=title, abstract, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword, floating subheading word] 3. exp seroprevalence/ or exp prevalence/ 4. exp seroepidemiology/ 5. exp incidence/ 6. (prevalen* or inciden* or epidemiolog* or sero*epidemiolog* or sero*prevalen* or sero*positiv*).mp. [mp=title, abstract, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword, floating subheading word] 7. exp intravenous drug abuse/ 8. (drug and (intraven* or inject*)).mp. [mp=title, abstract, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword, floating subheading word] 9. 1 or 2 10. 3 or 4 or 5 or 6 11. 7 or 8 12. 9 and 10 and 11 162
      Web Of Science TOPIC: ("human herpesvirus 8" OR "hhv-8" OR "hhv8" OR "kshv" OR "kaposi sarcoma associated herpesvirus" OR "kaposi’s sarcoma associated herpesvirus" or "kaposi sarcoma-associated herpesvirus" or "kaposi’s sarcoma-associated herpesvirus" or "kaposi NEAR/3 herpesvirus" or "kaposi NEAR/3 virus") AND TOPIC: (prevalen* or inciden* or epidemiolog* or sero*epidemiolog* or sero*prevalen* or sero*positiv*) AND TOPIC: (drug and (intraven* or inject*)) 39
      CBM (("herpesvirus 8, human"[weighted: exploded]) OR ("KSHV"[common fields] OR "human herpesvirus 8"[common fields] OR "kaposi sarcoma associated herpesvirus"[common fields] OR "herpesvirus 8, human"[subject terms] OR "HHV-8"[common fields] OR "HHV8"[common fields] OR "herpesvirus 8"[common fields] OR "Kaposi%virus"[common fields]) AND (("Substance Abuse, Intravenous"[unweighted: exploded]) OR ("drug abuse"[common fields]) OR ("drug"[common fields])) (in Chinese) 5
      CNKI (SU='KSHV' or SU='HHV-8' or SU='HHV 8' or SU='HHV8' or SU='herpesvirus 8' or SU %'Kapo%virus') and (SU%'drug abuse' or SU%'drug') (in Chinese) 11
      Wanfang (Topic:("KSHV or HHV-8 or HHV 8 or herpesvirus 8") + Topic:(Kapo%virus ))* Topic:("drug abuse" or "drug") (in Chinese) 10

      Table S1.  Search strategy of the databases