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Compound Name PEDV FIPV IC50a (µmol/L) CC50b (µmol/L) EC50c (µmol/L) SId values CC50 (µmol/L) EC50 (µmol/L) SI values 1 3-(aminocarbonyl)-1-phenylpyridinium 0.1877 73.8 28.63 2.58 60.48 59.66 1.01 2 2, 3-dichloronaphthoquinone 6.765 21.79 38.45 0.56 36.7 46.03 0.80 a50% inhibitory concentration against PEDV 3CLpro;
b50% cytotoxic concentration in subcultured cells;
c50% effective concentration of test compound in inhibiting viral replication;
dselectivity index (SI = CC50/EC50). The IC50, CC50 and EC50 values were determined using GraphPad Prism 7Table 1. Antiviral activities of compounds 1 and 2 against PEDV and FIPV.
Figure 6 个
Table 1 个