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Volume 37 Issue 2
April 2022
    Citation: Ge Gao, Xue Hu, Yiwu Zhou, Juhong Rao, Xiaoyu Zhang, Yun Peng, Jiaxuan Zhao, Yanfeng Yao, Kunpeng Liu, Mengying Liang, Hang Liu, Fei Deng, Han Xia, Chao Shan, Zhiming Yuan. Infection and pathogenesis of the Delta variant of SARS-CoV-2 in Rhesus macaque .VIROLOGICA SINICA, 2022, 37(2) : 299-302.  http://dx.doi.org/10.1016/j.virs.2022.02.001
    shu

    Infection and pathogenesis of the Delta variant of SARS-CoV-2 in Rhesus macaque

    • a Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China

    • b State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China

    • c Department of Forensic Medicine, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430030, China

    • d University of Chinese Academy of Sciences, Beijing, 100049, China

    • e Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China

    • Highlights
      1. Delta variant of SARS-CoV-2 can effectively infect the Rhesus macaque.
      2. The Delta variant grows faster than the early strain isolated from Wuhan in late 2019.
      3. The shedding pattern, viral load and disease severity of Delta variant are similar with the early strain isolated from Wuhan in late 2019.
      4. This study supports the attributed rapid disease spread of the Delta variant.
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    • Electronic Supplementary Material

      10.1016j.virs.2022.02.001-ESM.docx

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      Infection and pathogenesis of the Delta variant of SARS-CoV-2 in Rhesus macaque

        Corresponding author: Han Xia, hanxia@wh.iov.cn
        Corresponding author: Chao Shan, shanchao@wh.iov.cn
        Corresponding author: Zhiming Yuan, yzm@wh.iov.cn
      • a Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China
      • b State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China
      • c Department of Forensic Medicine, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430030, China
      • d University of Chinese Academy of Sciences, Beijing, 100049, China
      • e Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China
      • Received Date: 03 December 2021
      • Accepted Date: 24 January 2022

      Abstract: Highlights
      1. Delta variant of SARS-CoV-2 can effectively infect the Rhesus macaque.
      2. The Delta variant grows faster than the early strain isolated from Wuhan in late 2019.
      3. The shedding pattern, viral load and disease severity of Delta variant are similar with the early strain isolated from Wuhan in late 2019.
      4. This study supports the attributed rapid disease spread of the Delta variant.

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