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Volume 37 Issue 3
June 2022
    Citation: Yue Lu, Ping He, Yuxuan Zhang, Yongwen Ren, Leiliang Zhang. The emerging roles of retromer and sorting nexins in the life cycle of viruses .VIROLOGICA SINICA, 2022, 37(3) : 321-330.  http://dx.doi.org/10.1016/j.virs.2022.04.014
    shu

    The emerging roles of retromer and sorting nexins in the life cycle of viruses

    • a Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250013, China;

    • Corresponding author: Leiliang Zhang, armzhang@hotmail.com
    • Received Date: 28 December 2021
      Accepted Date: 12 April 2022
      Available online: 02 May 2022
    • Retromer and sorting nexins (SNXs) transport cargoes from endosomes to the trans-Golgi network or plasma membrane. Recent studies have unveiled the emerging roles for retromer and SNXs in the life cycle of viruses, including members of Coronaviridae, Flaviviridae and Retroviridae. Key components of retromer/SNXs, such as Vps35, Vps26, SNX5 and SNX27, can affect multiple steps of the viral life cycle, including facilitating the entry of viruses into cells, participating in viral replication, and promoting the assembly of virions. Here we present a comprehensive updated review on the interplay between retromer/SNXs and virus, which will shed mechanistic insights into controlling virus infection.
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      The emerging roles of retromer and sorting nexins in the life cycle of viruses

        Corresponding author: Leiliang Zhang, armzhang@hotmail.com
      • a Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250013, China;
      • Received Date: 28 December 2021
      • Accepted Date: 12 April 2022

      Abstract: Retromer and sorting nexins (SNXs) transport cargoes from endosomes to the trans-Golgi network or plasma membrane. Recent studies have unveiled the emerging roles for retromer and SNXs in the life cycle of viruses, including members of Coronaviridae, Flaviviridae and Retroviridae. Key components of retromer/SNXs, such as Vps35, Vps26, SNX5 and SNX27, can affect multiple steps of the viral life cycle, including facilitating the entry of viruses into cells, participating in viral replication, and promoting the assembly of virions. Here we present a comprehensive updated review on the interplay between retromer/SNXs and virus, which will shed mechanistic insights into controlling virus infection.

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