Citation: Lei Yang, Yingshan Chen, Sha Li, Yuan Zhou, Yongli Zhang, Rongjuan Pei, Xinwen Chen, Yun Wang. Immunization of mice with vaccinia virus Tiantan strain yields antibodies cross-reactive with protective antigens of monkeypox virus .VIROLOGICA SINICA, 2023, 38(1) : 162-164.  http://dx.doi.org/10.1016/j.virs.2022.10.004

Immunization of mice with vaccinia virus Tiantan strain yields antibodies cross-reactive with protective antigens of monkeypox virus

  • Highlights
    1. The first study describing the cross-reactivity of antibodies elicited by a Chinese smallpox vaccine against monkeypox virus.
    2. Mice immunized with vaccinia virus Tiantan strain yield antibodies cross-reactive with monkeypox virus protective antigens.
    3. Cross-reactivities of VTT-elicited antibodies against monkeypox protective antigens are ranging from 33% to 94%.

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  • 10.1016j.virs.2022.10.004-ESM.docx
    1. Ahmed, S.F., Sohail, M.S., Quadeer, A.A., McKay, M.R., 2022. Vaccinia-virus-based vaccines are expected to elicit highly cross-reactive immunity to the 2022 monkeypox virus. Viruses 14, 1960.

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    3. Breman, J.G., Kalisa, R., Steniowski, M.V., Zanotto, E., Gromyko, A.I., Arita, I., 1980. Human monkeypox, 1970-79. Bull. World Health Organ. 58, 165-182.

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    9. Heraud, J.M., Edghill-Smith, Y., Ayala, V., Kalisz, I., Parrino, J., Kalyanaraman, V.S., Manischewitz, J., King, L.R., Hryniewicz, A., Trindade, C.J., Hassett, M., Tsai, W.P., Venzon, D., Nalca, A., Vaccari, M., Silvera, P., Bray, M., Graham, B.S., Golding, H., Hooper, J.W., Franchini, G., 2006. Subunit recombinant vaccine protects against monkeypox. J. Immunol. 177, 2552-2564.

    10. Hirao, L.A., Draghia-Akli, R., Prigge, J.T., Yang, M., Satishchandran, A., Wu, L., Hammarlund, E., Khan, A.S., Babas, T., Rhodes, L., Silvera, P., Slifka, M., Sardesai, N.Y., Weiner, D.B., 2011. Multivalent smallpox DNA vaccine delivered by intradermal electroporation drives protective immunity in nonhuman primates against lethal monkeypox challenge. J. Infect. Dis. 203, 95-102.

    11. Kaever, T., Matho, M.H., Meng, X., Crickard, L., Schlossman, A., Xiang, Y., Crotty, S., Peters, B., Zajonc, D.M., 2016. Linear epitopes in vaccinia virus A27 are targets of protective antibodies induced by vaccination against smallpox. J. Virol. 90, 4334-4345.

    12. Kaever, T., Meng, X., Matho, M.H., Schlossman, A., Li, S., Sela-Culang, I., Ofran, Y., Buller, M., Crump, R.W., Parker, S., Frazier, A., Crotty, S., Zajonc, D.M., Peters, B., Xiang, Y., 2014. Potent neutralization of vaccinia virus by divergent murine antibodies targeting a common site of vulnerability in L1 protein. J. Virol. 88, 11339-11355.

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    Immunization of mice with vaccinia virus Tiantan strain yields antibodies cross-reactive with protective antigens of monkeypox virus

      Corresponding author: Xinwen Chen, chen_xinwen@gzlab.ac.cn
      Corresponding author: Yun Wang, wangyun@wh.iov.cn
    • a. State Key Laboratory of Virology, Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China;
    • b. University of Chinese Academy of Sciences, Beijing, 100049, China;
    • c. Innovation Center for Pathogen Research, Guangzhou Laboratory, Guangzhou, 510320, China

    Abstract: Highlights
    1. The first study describing the cross-reactivity of antibodies elicited by a Chinese smallpox vaccine against monkeypox virus.
    2. Mice immunized with vaccinia virus Tiantan strain yield antibodies cross-reactive with monkeypox virus protective antigens.
    3. Cross-reactivities of VTT-elicited antibodies against monkeypox protective antigens are ranging from 33% to 94%.

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