Citation: Jie-Mei Yu, Ze-Yin Liang, Yuan-Hui Fu, Xiang-Lei Peng, Yan-Peng Zheng, Yu-Jun Dong, Jin-Sheng He. Coexistence of adeno-associated virus 2 with adenovirus 18 or herpesvirus may be associated with severe lingual papillomatosis in an immunocompromised individual .VIROLOGICA SINICA, 2024, 39(4) : 705-707.  http://dx.doi.org/10.1016/j.virs.2024.06.006

Coexistence of adeno-associated virus 2 with adenovirus 18 or herpesvirus may be associated with severe lingual papillomatosis in an immunocompromised individual

cstr: 32224.14.j.virs.2024.06.006
  • Corresponding author: Yu-Jun Dong, dongy@bjmu.edu.cn
    Jin-Sheng He, jshhe@bjtu.edu.cn
  • Received Date: 16 October 2023
    Accepted Date: 19 June 2024
    Available online: 22 June 2024
  • Highlights
    1. Viral metagenomics analysis was conducted on samples from an HSCT recipient experiencing severe lingual papillomatosis.
    2. Coexistence of AAV2 with AdV18 in fecal and HSV-1 in tissue samples was detected.
    3. A second complete genome of AdV18 was obtained in this study and is available in public databases.

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    1. Armstrong, A. E., Rossoff, J., Hollemon, D., Hong, D. K., Muller, W. J., & Chaudhury, S., 2019. Cell-free DNA next-generation sequencing successfully detects infectious pathogens in pediatric oncology and hematopoietic stem cell transplant patients at risk for invasive fungal disease. Pediatr. Blood Cancer 66, e27734.

    2. Gates, S., Andreani, J., Dewar, R., Smith, D.B., Templeton, K., Child, H.T., Breuer, J., Golubchik, T., Bassano, I., Wade, M.J. et al., 2023. Postpandemic rebound of adeno-associated virus type 2 (AVV2) infections temporally associated with an outbreak of unexplained severe acute hepatitis in children in the United Kingdom. J. Med. Virol. 95, e28921.

    3. Ho, A., Orton, R., Tayler, R., Asamaphan, P., Herder, V., Davis, C., Tong, L., Smollett, K., Manali, M., Allan, J. et al., 2023. Adeno-associated virus 2 infection in children with non-A-E hepatitis. Nature, 617, 555-563.

    4. Hoeben, R.C., Uil, T.G., 2013. Adenovirus DNA replication. Cold Spring Harb. Perspect. Biol. 5, a013003.

    5. Huebner, R.J., Rowe, W.P., Lane, W.T., 1962. Oncogenic effects in hamsters of human adenovirus types 12 and 18. Proc. Natl. Acad. Sci. U S A. 48, 2051-2058.

    6. La Bella, T., Imbeaud, S., Peneau, C., Mami, I., Datta, S., Bayard, Q., Caruso, S., Hirsch, T.Z., Calderaro J., Morcrette G. et al., 2020. Adeno-associated virus in the liver: natural history and consequences in tumour development. Gut. 69, 737-747.

    7. Liu, H.T., Naismith, J.H., Hay, R.T., 2000. Identification of conserved residues contributing to the activities of adenovirus DNA polymerase. J. Virol. 74, 11681-11689.

    8. Meier, A.F., Fraefel, C., Seyffert, M., 2020. The interplay between adeno-associated virus and its helper viruses. Viruses 12, 662.

    9. Moyo, S.J., Hanevik, K., Blomberg, B., Kommedal, O., Nordbo, S.A., Maselle, S., Langeland N., 2014. Prevalence and molecular characterisation of human adenovirus in diarrhoeic children in Tanzania; a case control study. BMC Infect. Dis. 14, 666.

    10. Peng, J.M., Du, B., Qin, H.Y., Wang, Q., Shi, Y., 2021. Metagenomic next-generation sequencing for the diagnosis of suspected pneumonia in immunocompromised patients. J. Infect. 82, 22-27.

    11. Qu, Y.H., Ding, W.J., Liu, S., Wang, X.J., Wang, P.F., Liu, H.Y., Xia, H., Chen, Y., Jiang, H., 2022. Metagenomic next-generation sequencing vs. Traditional pathogen detection in the diagnosis of infection after allogeneic hematopoietic stem cell transplantation in children. Front. Microbiol. 13, 868160.

    12. Sahin, U., Toprak, S.K., Atilla, P.A., Atilla, E., Demirer, T., 2016. An overview of infectious complications after allogeneic hematopoietic stem cell transplantation. J. Infect. Chemother. 22, 505-514.

    13. Schuler, B.A., Nelson, E.T., Koziura, M., Cogan, J.D., Hamid, R., Phillips, J.A., 2022. Lessons learned: Next-generation sequencing applied to undiagnosed genetic diseases. J. Clin. Invest. 132, e154942.

    14. Wang, D., Tai, P.W.L., Gao, G.P., 2019. Adeno-associated virus vector as a platform for gene therapy delivery. Nat. Rev. Drug Discov. 18, 358-378.

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    Coexistence of adeno-associated virus 2 with adenovirus 18 or herpesvirus may be associated with severe lingual papillomatosis in an immunocompromised individual

      Corresponding author: Yu-Jun Dong, dongy@bjmu.edu.cn
      Corresponding author: Jin-Sheng He, jshhe@bjtu.edu.cn
    • a. College of Life Sciences and Bioengineering, Beijing Jiaotong University, Beijing, 100044, China;
    • b. Department of Hematology, Peking University First Hospital, Beijing, 100034, China

    Abstract: Highlights
    1. Viral metagenomics analysis was conducted on samples from an HSCT recipient experiencing severe lingual papillomatosis.
    2. Coexistence of AAV2 with AdV18 in fecal and HSV-1 in tissue samples was detected.
    3. A second complete genome of AdV18 was obtained in this study and is available in public databases.

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