First identification of Tusavirus in calf intestinal tissue suggests interspecies transmission and genomic variation

Yang Song; Weiwei Gai; Jiaxin Sun; Xiangyu Lv; Haojie Sang; Shuai Guo; Jingqiang Ren; Jingbo Zhai; Shubo Wen

doi:10.1016/j.virs.2025.09.006

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Volume 40 Issue 5

October 2025

Citation: Yang Song, Weiwei Gai, Jiaxin Sun, Xiangyu Lv, Haojie Sang, Shuai Guo, Jingqiang Ren, Jingbo Zhai, Shubo Wen. First identification of Tusavirus in calf intestinal tissue suggests interspecies transmission and genomic variation .VIROLOGICA SINICA, 2025, 40(5) : 860-862. http://dx.doi.org/10.1016/j.virs.2025.09.006

First identification of Tusavirus in calf intestinal tissue suggests interspecies transmission and genomic variation

Yang Song ^a,b ,
Weiwei Gai ^a ,
Jiaxin Sun ^a ,
Xiangyu Lv ^a ,
Haojie Sang ^a ,
Shuai Guo ^d ,
Jingqiang Ren ^{c
,,} ,
Jingbo Zhai ^{b
,,} ,
Shubo Wen ^{a,b
,,}

a. College of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, 028000, China;
b. Key Laboratory of Zoonose Prevention and Control, Inner Mongolia Autonomous Region, Tongliao, 028000, China;
c. Institute of Virology, Wenzhou University, Wenzhou, 325035, China;
d. Animal Disease Prevention and Control Center of Tongliao, Tongliao, 028000, China

Corresponding author: Jingqiang Ren, rjq207@163.com
Jingbo Zhai, jbzhai@imun.edu.cn
Shubo Wen, wen0516@126.com
Received Date: 20 May 2025
Accepted Date: 24 September 2025
Available online: 26 September 2025

Abstract

Highlights1. This is the first identification of Tusavirus in calf tissue in China, expanding its host species and geographical range.2. Genomic analysis reveals conservation, with nucleotide insertions in the VP1 gene and deletions in both VP1 and VP2 genes.3. Phylogenetic analysis shows close evolutionary linkage between bovine and ovine TuV strains.

Electronic Supplementary Material

10.1016j.virs.2025.09.006-ESM1.docx

10.1016j.virs.2025.09.006-ESM1.docx
References
1. Davies, H., Dastjerdi, A., Everest, D., Floyd, T., Collins, R., Mcfadzean, H., Reuter, G.,Reichel, R., 2024. Incidental finding of a human-like tusavirus in a lamb with lip lesions and fatal pneumonia. J Gen Virol, 105.
2. He, H., Li, Y., Chen, J., Xian, J., Zheng, L., Sun, H., Fan, S., Fu, J., Li, Q., Chen, C., Liang, M., Zhang, M., Wu, R., Xiao, G.,Chen, Q., 2023. Identification and genetic characteristics of tusavirus in fecal samples of patients with chronic diseases in Guangzhou, China. Frontiers in Microbiology, 14.
3. Phan, T.G., Sdiri-Loulizi, K., Aouni, M., Ambert-Balay, K., Pothier, P., Deng, X.,Delwart, E., 2014. New parvovirus in child with unexplained diarrhea, Tunisia. Emerg Infect Dis, 20, 1911-1913.
4. Reuter, G., Pankovics, P., Laszlo, Z., Gaspar, G., Hui, A., Delwart, E.,Boros, A., 2022. Human-stool-associated tusavirus (Parvoviridae) in domestic goats and sheep. Arch Virol, 167, 1307-1310.
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First identification of Tusavirus in calf intestinal tissue suggests interspecies transmission and genomic variation

Corresponding author: Jingqiang Ren, rjq207@163.com

Corresponding author: Jingbo Zhai, jbzhai@imun.edu.cn

Corresponding author: Shubo Wen, wen0516@126.com

a. College of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, 028000, China;
b. Key Laboratory of Zoonose Prevention and Control, Inner Mongolia Autonomous Region, Tongliao, 028000, China;
c. Institute of Virology, Wenzhou University, Wenzhou, 325035, China;
d. Animal Disease Prevention and Control Center of Tongliao, Tongliao, 028000, China

Received Date: 20 May 2025
Accepted Date: 24 September 2025

Abstract: Highlights1. This is the first identification of Tusavirus in calf tissue in China, expanding its host species and geographical range.2. Genomic analysis reveals conservation, with nucleotide insertions in the VP1 gene and deletions in both VP1 and VP2 genes.3. Phylogenetic analysis shows close evolutionary linkage between bovine and ovine TuV strains.