THE INTERFERON OF MICE WITH EXPERIMENTAL INFECTION OF MURINE CYTOMEGALOVIRUS

C57BL/6 mice were infected intraperitoneally by murine cytomegalovirus (MCMV).Secretion of virus from salivary glands was positive up to 102 days.From 6 to 32 days after infection, no interferon(IFN)activity could be detected in all collectcd serum samples. However, spleen cells from these infected mice still responded to IFN inducers in vitro. All spleen cells produced comparable IFN to NDV and Con A induction as that of the control group,except that there was a transient decrease of IFN production to NDV ...