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Volume 05 Issue 3
June 1990
    Citation: ZHANG Yong-Yuan, YAN Pu, LI Lin, HONG Yao-Kun, HAO Lian-Jie. Morphology, Distribution and Its Signification of Intrahepatic HBV DNA in Liver Disease: A Study by in Situ Hydridization .VIROLOGICA SINICA, 1990, 5(3) : 265.
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    Morphology, Distribution and Its Signification of Intrahepatic HBV DNA in Liver Disease: A Study by in Situ Hydridization

    • 1.

      Clinical Immunology Research Unit

    • 2.

      Department of Infectious Diseases

    • Available online: 05 September 1990
    • A biotin-labeled DNA probe specific for hepatitis B virus(HBV)nucleotide sequences was hybridized in situ to liver tissue of 129 cases with liver disease. It was found that HBVDNA was predominantely visualized in cytoplasm of hepatocytes in three ways,cytoplasmic compact pattern,discrete pattern abd inclusion pattern. Its distribution in parenchyma within the section of specimens may be defined as lobular, focal and spotty. The detection of intrahepatic HBVDNA depanded on two factors at least in present stu...
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      Morphology, Distribution and Its Signification of Intrahepatic HBV DNA in Liver Disease: A Study by in Situ Hydridization

      • 1. Clinical Immunology Research Unit
      • 2. Department of Infectious Diseases

      Abstract: A biotin-labeled DNA probe specific for hepatitis B virus(HBV)nucleotide sequences was hybridized in situ to liver tissue of 129 cases with liver disease. It was found that HBVDNA was predominantely visualized in cytoplasm of hepatocytes in three ways,cytoplasmic compact pattern,discrete pattern abd inclusion pattern. Its distribution in parenchyma within the section of specimens may be defined as lobular, focal and spotty. The detection of intrahepatic HBVDNA depanded on two factors at least in present stu...

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