Comparison of Two Pre-s Proteins in Hepatocytes with HBV Replication Status by in situ HBV DNA Hybridization Assay
Abstract: To compare relationship between two pre-s proteins and HBV replication HBV DNA in situ hybridization was applied to a group of patients with chronic hepatitis by bio-probe, in conjunction of detection of intrahepatic HBsAg, HBcAg, pre-s1 and pre-s2 antigens. It was found that the positive rate for pre-s1 was up to 75%(15/20), being significantly higher than that of pre-s2 (35%) in the same group. More importantly the presence of pre..sl, rather than pre-s2, was in parallel with the presence of intrahepatic ...