Study of EHFV Directly Activating Complement C3 in Vitro

The antigens of four EHFV strains from different sources(Chen, H8205, ALC96, R22)purified by sucrose gradient centrifugation incubated with normal human sera in 37℃ for 30 minutes Cross-immunoelectrophoresis was used to detect whether complement C_3 was activated. The results showed that Chen, H8205, R22 strains antigens can directly activate C_3, typical degradative peak was found after electrophoresis. But ALC96 and normal antigen were negative. Ability of activating C_3 of EHFV antigens was related to th...