Citation: JIA Li-Li, ZHENG Zheng, YU Yong-Xin. Pathogenicity and Immunogenicity of Attenuated Japanese Encephalitis Vaccine (SA_(14)-14-2) in Immune-Inhibited Mice .VIROLOGICA SINICA, 1993, 8(1) : 20.

Pathogenicity and Immunogenicity of Attenuated Japanese Encephalitis Vaccine (SA_(14)-14-2) in Immune-Inhibited Mice

  • Available online: 05 March 1993
  • In this study, three-week-old mice, 12—14g, were treated by cytoxan three times. They were then injected subcutaneousiy with SA_(14)-14-2 live vaccine, no mouse was killed by the attenuated virus. When the immune-inhibited mice were immunized with the attenuated live vaccine and the inactivated JE vaccine, they exhibited different immune responses to the both vaccines. Those immunized with the attenuated live virus showed better protective effect (protective rate 56—80%)against JE virulent virus challenging...

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    Pathogenicity and Immunogenicity of Attenuated Japanese Encephalitis Vaccine (SA_(14)-14-2) in Immune-Inhibited Mice

    • 1. Notional Institute lor Conlro1 掳f Pharmaceutical and Biological Products
    • 2. Beijing 100050

    Abstract: In this study, three-week-old mice, 12—14g, were treated by cytoxan three times. They were then injected subcutaneousiy with SA_(14)-14-2 live vaccine, no mouse was killed by the attenuated virus. When the immune-inhibited mice were immunized with the attenuated live vaccine and the inactivated JE vaccine, they exhibited different immune responses to the both vaccines. Those immunized with the attenuated live virus showed better protective effect (protective rate 56—80%)against JE virulent virus challenging...

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