Localization and distribution of HSP70 mRNA and Hantann virus in autopsy tissue of the patients with EHF and in virus-infected cells

With in situ hybridization technique the localization and distribution of HSP70 mRNA and Hantaan virus RNA in the tissues of 30 cadavers with epidemic hemorrhagic fever (EHF), which were collected from different EHF epidemic foci in China, were examined. HSP70 mRNA was detected in most of the 30 cases and consistent with the localization and distribution of viral RNA.The distribution of HSP70 mRNA was partly related with the pathogenesis of HFRS. The over expression of HSP70 was also found in the virus infected Vero E 6 cells. It suggested that HSP was associated with the infection of Hantaan virus.