Citation: CHEN Jiong, CHENG Ye, CHEN Jian-Beng. Activity Comparison and Mechanism of Two Promoters of Bovine Foamy Virus .VIROLOGICA SINICA, 2000, 15(2) : 93-096.

Activity Comparison and Mechanism of Two Promoters of Bovine Foamy Virus

  • Available online: 05 June 2000
  • Abstract:Two promoters.LTR (1ong terminal repeat)and IP (internal promoter),exist in genomes of foamy viruses.Ge1l transfection and transient expression assay demonstrated that!the basal activity of BFV (bovine foamy virus)IP is much higher than that of BFV LTR;transacti. vator of BF 一Borf-1,which activates gene expression directed by BFV LTR,aLso hmctions on BFV IP with an activation foId higher than tha t on LTR .The results suggest that BFv IP and LTR may regulate viral gene expression by difierent mechan isms,and that Bod-1 ma y stimulate BFV IP and LTR in diferent ways.In addition.an in vivo DNA compe tition assay demonstrat ed that a comm on transcxiption factor may be involved in both mechanisms of the two promoters .

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    Activity Comparison and Mechanism of Two Promoters of Bovine Foamy Virus

    • 1. College of life 

    Abstract: Abstract:Two promoters.LTR (1ong terminal repeat)and IP (internal promoter),exist in genomes of foamy viruses.Ge1l transfection and transient expression assay demonstrated that!the basal activity of BFV (bovine foamy virus)IP is much higher than that of BFV LTR;transacti. vator of BF 一Borf-1,which activates gene expression directed by BFV LTR,aLso hmctions on BFV IP with an activation foId higher than tha t on LTR .The results suggest that BFv IP and LTR may regulate viral gene expression by difierent mechan isms,and that Bod-1 ma y stimulate BFV IP and LTR in diferent ways.In addition.an in vivo DNA compe tition assay demonstrat ed that a comm on transcxiption factor may be involved in both mechanisms of the two promoters .

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