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Volume 15 Issue 3
June 2000
    Citation: SHU Zhen-Yu, ZHOU Yuan-Beng, ZHANG Qing-Xiu, GAO Guo-Quan, DENG Yi-Qun, MA Jian-Quan. Four Kinds of EBV-Antisense Oiigodeoxynucleotides Effect on Proliferation of EBV Containing SUNE-1 Cell Line .VIROLOGICA SINICA, 2000, 15(3) : 209-213.
    shu

    Four Kinds of EBV-Antisense Oiigodeoxynucleotides Effect on Proliferation of EBV Containing SUNE-1 Cell Line

    • 1.

      Department of Bioclwmistry, Sun yat-sen 

    • Available online: 05 September 2000
    • Poorly differentiated nasopharyngeal carcinoma (SUNE 1) cell line was cultured with Epstein Barr virus (EBV) BHRF1, DNase, thymidine kinase (TK) and nuclear antigen 1 (EBNA1) antisense oligodeoxynucleotide (ASO) for 48 h respectively. Inhibited proliferation of SUNE 1 was only observed in the absence of fetal calf serum (FCS) and exposed to EBV BHRF1 ASO. The results from electron microscopy and agarose gel electrophoresis indicated that apoptosis only appeared in SUNE 1 cells exposed to BHRF1 ASO and absence of FCS. The other 3 kinds of EBV ASOs had not the similar effects at the same concentration.
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      Four Kinds of EBV-Antisense Oiigodeoxynucleotides Effect on Proliferation of EBV Containing SUNE-1 Cell Line

      • 1. Department of Bioclwmistry, Sun yat-sen 

      Abstract: Poorly differentiated nasopharyngeal carcinoma (SUNE 1) cell line was cultured with Epstein Barr virus (EBV) BHRF1, DNase, thymidine kinase (TK) and nuclear antigen 1 (EBNA1) antisense oligodeoxynucleotide (ASO) for 48 h respectively. Inhibited proliferation of SUNE 1 was only observed in the absence of fetal calf serum (FCS) and exposed to EBV BHRF1 ASO. The results from electron microscopy and agarose gel electrophoresis indicated that apoptosis only appeared in SUNE 1 cells exposed to BHRF1 ASO and absence of FCS. The other 3 kinds of EBV ASOs had not the similar effects at the same concentration.

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